| 查看: 2002 | 回复: 10 | |||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
翻译成中文
|
|||
|
In 1957, Jacobson et al performed bilateral nephrectomies on rats and showed that these animals no longer responsed to phlebotomy or cobalt administration with increased Ep production. Rats that only had their ureters ligated and that developed similar elevations of the blood urea nitrogen still responded to cobalt or phlebotomy in the usual fashion .Similiar results were found in mice , rabbits , baboons , and dogs .In humans , Ep levels were found to be low in the serum of anemic patients with severe uremia , but after successful renal transplantation increases in blood Ep levels and hematocrit were observed. Furthermore , erythropoietic activity was detected in the perfusates from isolated rabbit kidneys and was produced by renal cell cultures in vitro . Although the evidence to support the renal origin of Ep was substantial , Ep had not been extracted from normal kidneys or from various normal kidney fractions until very recently. To explain this difficulty , three different hypotheses have been proposed . Current evidence indicates that the stimulation of Ep production by hypoxia or ischemia may be mediated via increases in renal prostaglandin and cyclic AMP levels . The administration of cyclic AMP to plethoric mice increased Ep production and led to and increased red cell mass in normal mice . prostaglandin raised the renal cyclic AMP concentration in isolated perfused dog kidneys as well as the amount of Ep in the perfusates ;the administration of prostaglandin to polycythemic mice increased both prostaglandin E and Ep blood levels in dogs . The effect on both these parameters as well as on hypoxia-induced Ep production was blocked by indomethacin, a known inhibitor of prostaglandin synthesis .Since prostaglandins are located mainly in the renal medulla , while Ep has been identified by fluorescent antibodies in the renal cortex , these observations are most consistent with the hypothesis that renal hypoxia or ischemia produces a medullary release of prostaglandin which in turn elevates renal corticla cyclic AMP levels. The newly formed cyclic AMP THEN may activate a protein kinase that leads to increased Ep production , possibly through phosphorylation of a precursor renal erythropoietic factor. Although the kidney is the major site controlling Ep formation , after bilateral nephrectomy the production of hormone and erythropoiesis continues in most species , but at a considerably lower level .Anephric mice and rats retain about 10%of their original capacity to increase Ep production in the presence of hypoxia , while anephric patients who become very anemic have Ep in their plasma .The extrarenal Ep of rats appears to be similar to Ep of renal origin since it stimulates heme synthesis by marrow cells and is neutralized by antiserum to urinary Ep . Several lines of study point to the liver as the primary site of extrarenal Ep production. Ep is produced primarily in the liver during fetal life .Hepatectomy abolishes hypoxia-stimulated hormone production in anephric rats , but not in animals with intact kidneys . In partially hepatectomized rats , the extrarenal Ep response to hypoxia correlates directly with liver regeneration and is most increased during the period of greatest proliferation . Administration of colloidal carbon or zymosan, which induces liver reticuloendothelial cell hyperplasia, enhances Ep production in nephrectomized rats exposed to hypoxia .This effect, which is also blocked by hepatectomy , suggests that the liver reticuloendothelial system may be and important factor in extrarenal Ep production . |
回复此楼» 猜你喜欢
博士读完未来一定会好吗
已经有14人回复
-
心脉受损
已经有4人回复
-
Springer期刊投稿求助
已经有4人回复
-
读博
已经有3人回复
-
小论文投稿
已经有3人回复
-
Bioresource Technology期刊，第一次返修的时候被退回好几次了
已经有9人回复
-
到新单位后，换了新的研究方向，没有团队，持续积累2区以上论文，能申请到面上吗
已经有8人回复
-
申请2026年博士
已经有6人回复
-
请问哪里可以有青B申请的本子可以借鉴一下。
已经有5人回复
» 抢金币啦！回帖就可以得到:
桂林理工大学材料科学与工程学院诚聘青年教师
+1/121
-
因为雪而勾起的一些往事
+1/63
-
浙江大学药学院张小昀课题组诚聘博士后、研究助理 (核酸化学生物学方向)
+1/63
-
双一流大学湘潭大学“化工过程模拟与强化”国家地方联合工程研究中心招收各类博士生
+1/60
-
坐标山东东营，诚征女友
+1/57
-
QS TOP100英国南安普顿大学数字健康与生医工招博后，博士，Fellowship，访问学者
+1/32
-
2026年博士招生--北京理工大学交叉学科（航空，力学，能动，计算机等方向）
+1/32
-
中南大学冶金与环境学院陈伟老师招收环境科学与工程2026年博士生1人
+1/29
-
北京科技大学鲁启鹏招收2026年博士生1名
+1/29
-
2026年博士招生--北京理工大学交叉学科（航空，力学，能动，计算机等方向）
+1/29
-
智慧能源中心招聘启事|博士后 科研助理
+1/27
-
澳门科技大学2026年数学博士招生——计算物理与数学课题组: 相场与计算流体动力学
+1/11
-
招聘2026年入学博士生
+1/7
-
招若干有机合成人员 (中山大学)
+1/6
-
哈尔滨工业大学（深圳）赵怡潞课题组诚招博士后
+1/6
-
大连工业杰青、长江团队-生物质材料方向招收2026级博士生
+1/5
-
天津大学建工学院课题组诚招2026级博士研究生
+1/5
-
北京理工大学（珠海）医疗机器人实验室现招收2026年博士研究生
+1/4
-
上海大学长江学者钟云波教授团队招收外场冶金或材料加工方向2026年博士研究生
+1/3
-
东北师范大学国家杰青汤庆鑫教授团队招收博士研究生
+1/1
★ ★ ★ ★ ★ ★ ★ ★ ★ ★
ringzhu(金币+10): ~~ 2011-03-17 15:20:49
ringzhu(金币+10): ~~ 2011-03-17 15:20:49
| Current evidence indicates that the stimulation of Ep production by hypoxia or ischemia may be mediated via increases in renal prostaglandin and cyclic AMP levels . 目前已证明缺氧或缺血促进上皮细胞的产生，肾前列腺素和环磷酸腺苷的增加也可能会导致上皮细胞的产生。The administration of cyclic AMP to plethoric mice increased Ep production and led to and increased red cell mass in normal mice . 环磷酸腺苷促进多血症老鼠的上皮细胞数量增加，而对正常鼠则会增加红细胞的数量。prostaglandin raised the renal cyclic AMP concentration in isolated perfused dog kidneys as well as the amount of Ep in the perfusates 在灌注狗实验中，前列腺素会提高肾脏中环磷酸腺苷的浓度，上皮细胞的数量也会增多;the administration of prostaglandin to polycythemic mice increased both prostaglandin E and Ep blood levels in dogs此外，前列腺素会提高多血症鼠（polycythemic 单词没查出来什么意思）的前列腺素E，增加狗血液中的上皮细胞量 . The effect on both these parameters as well as on hypoxia-induced Ep production was blocked by indomethacin, a known inhibitor of prostaglandin synthesis 消炎痛是一种常用的前列腺素产生抑制剂，前列腺素对前列腺素E及血液中上皮细胞和缺氧生成的上皮细胞的作用会受到消炎痛的抑制.Since prostaglandins are located mainly in the renal medulla , while Ep has been identified by fluorescent antibodies in the renal cortex ,有种猜想认为肾脏缺氧或缺血导致肾髓质释放前列腺素，进而前列腺素促进皮质中环磷酸腺苷的产生，新生成的环磷酸腺苷可能通过身形红细胞生成因子的磷酸化作用，刺激蛋白激酶产生上皮细胞。因为前列腺素主要存在于肾髓质中，肾脏皮层的上皮细胞可以用荧光抗体进行识别，实验观测结果与上述猜想相吻合。these observations are most consistent with the hypothesis that renal hypoxia or ischemia produces a medullary release of prostaglandin which in turn elevates renal corticla cyclic AMP levels. The newly formed cyclic AMP THEN may activate a protein kinase that leads to increased Ep production , possibly through phosphorylation of a precursor renal erythropoietic factor. |
7楼2011-03-09 16:40:34
wjmsicuan(金币+1, 翻译EPI+1): 很差劲，不过还是慰问下！！ 2011-03-06 19:43:10
 在1957年，Jacobson 等人对大鼠首先进行双侧肾切除，之后放血或用钴处理，发现Ep不增高，然而，如果预先只是将大鼠输尿管结扎，其血液尿素含量增高，之后放血或用钴处理，其Ep，和正常鼠一样，增高。在小鼠，家兔，狒狒和狗身上做相同的实验，获得的结果相似。在人群中，伴有严重尿毒症的白血病患者的血液Ep水平较低，但在肾移植手术成功后，血液Ep水平升高，且血细胞计数也有所增加。此外，对分离的家兔的肾灌流液，即体外培养的肾细胞的红血球生成活性进行检测。虽然支持Ep 来源于肾的证据可靠，但直到现在，人们还没能从正常的肾或不同的肾fractions提取出 Ep 。为了解释这个难题，三个不同的假说被提出。最新证据显示，由组织缺氧和局部缺血诱导的 Ep的产生是通过上调肾脏前列腺素和cAMP水平来介导的。用cAMP处理多血症小鼠可增加Ep的产生，处理正常小鼠可导致红细胞块的增加。前列腺可以上调体外灌流的狗肾脏的cAMP浓度，同时也可以上调灌流液中Ep含量。用前列腺素处理红细胞增多小鼠，可以增加血液前列腺素E含量，也可以增加狗的血Ep含量。对这2个参数的影响和组织缺氧诱导的Ep增多可以被消炎药茚甲新阻断，茚甲新是前列腺素合成的抑制剂。由于前列腺素主要分布于肾髓，而Ep已通过荧光抗体被鉴定存在于肾皮质， 这些观察结果与假设一致，即肾缺氧或缺血诱导肾髓释放前列腺素，而前列腺素反过来又上调肾皮质的cAMP浓度。新生成的cAMP，接下来可能可以激活蛋白激酶增加Ep的产生，很可能是通过磷酸化肾红血球生成因子前体来实现的。 虽然肾是控制Ep生成的主要场所，在大多数物种经历双肾切除手术之后，激素和红血球产生过程仍然继续，只是以相当低的速度。无肾小鼠和无肾大鼠在缺氧条件下仍然保留约10%生产Ep的能力,但无肾的病人，常表现为严重贫血，在血浆中含有Ep。大鼠肾外的Ep和肾来源的Ep很相似，也可以刺激骨髓细胞生成亚铁血红素，可以被抗尿Ep的抗血清中和。一些研究团队认为肝脏是肾外Ep产生的最初部位。在胎儿期 Ep主要在肝脏中产生。在无肾大鼠中，肝脏切除可以阻断低氧诱导激素的产生，但在有完整肾的动物中肝脏切除不可阻断。在部分肝脏切除的大鼠中， 肾外Ep对低氧的反应直接与肝再生相关，且在增殖最旺盛期肾外Ep增加最快。 用胶状碳或酵母聚糖诱导肝网状内皮组织增生，可以促进受低氧胁迫的肾切除大鼠的Ep的产生。这个效应同样可以被肝切除手术阻断，提示肝网状内皮系统 可能是肾外Ep产生的重要因素。 第一次翻译，凑活着看啊 |
2楼2011-03-05 20:56:56
3楼2011-03-05 21:04:18
4楼2011-03-06 21:18:12