| 查看: 2139 | 回复: 10 | |||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
翻译成中文
|
|||
|
In 1957, Jacobson et al performed bilateral nephrectomies on rats and showed that these animals no longer responsed to phlebotomy or cobalt administration with increased Ep production. Rats that only had their ureters ligated and that developed similar elevations of the blood urea nitrogen still responded to cobalt or phlebotomy in the usual fashion .Similiar results were found in mice , rabbits , baboons , and dogs .In humans , Ep levels were found to be low in the serum of anemic patients with severe uremia , but after successful renal transplantation increases in blood Ep levels and hematocrit were observed. Furthermore , erythropoietic activity was detected in the perfusates from isolated rabbit kidneys and was produced by renal cell cultures in vitro . Although the evidence to support the renal origin of Ep was substantial , Ep had not been extracted from normal kidneys or from various normal kidney fractions until very recently. To explain this difficulty , three different hypotheses have been proposed . Current evidence indicates that the stimulation of Ep production by hypoxia or ischemia may be mediated via increases in renal prostaglandin and cyclic AMP levels . The administration of cyclic AMP to plethoric mice increased Ep production and led to and increased red cell mass in normal mice . prostaglandin raised the renal cyclic AMP concentration in isolated perfused dog kidneys as well as the amount of Ep in the perfusates ;the administration of prostaglandin to polycythemic mice increased both prostaglandin E and Ep blood levels in dogs . The effect on both these parameters as well as on hypoxia-induced Ep production was blocked by indomethacin, a known inhibitor of prostaglandin synthesis .Since prostaglandins are located mainly in the renal medulla , while Ep has been identified by fluorescent antibodies in the renal cortex , these observations are most consistent with the hypothesis that renal hypoxia or ischemia produces a medullary release of prostaglandin which in turn elevates renal corticla cyclic AMP levels. The newly formed cyclic AMP THEN may activate a protein kinase that leads to increased Ep production , possibly through phosphorylation of a precursor renal erythropoietic factor. Although the kidney is the major site controlling Ep formation , after bilateral nephrectomy the production of hormone and erythropoiesis continues in most species , but at a considerably lower level .Anephric mice and rats retain about 10%of their original capacity to increase Ep production in the presence of hypoxia , while anephric patients who become very anemic have Ep in their plasma .The extrarenal Ep of rats appears to be similar to Ep of renal origin since it stimulates heme synthesis by marrow cells and is neutralized by antiserum to urinary Ep . Several lines of study point to the liver as the primary site of extrarenal Ep production. Ep is produced primarily in the liver during fetal life .Hepatectomy abolishes hypoxia-stimulated hormone production in anephric rats , but not in animals with intact kidneys . In partially hepatectomized rats , the extrarenal Ep response to hypoxia correlates directly with liver regeneration and is most increased during the period of greatest proliferation . Administration of colloidal carbon or zymosan, which induces liver reticuloendothelial cell hyperplasia, enhances Ep production in nephrectomized rats exposed to hypoxia .This effect, which is also blocked by hepatectomy , suggests that the liver reticuloendothelial system may be and important factor in extrarenal Ep production . |
回复此楼» 猜你喜欢
0703化学调剂，求导师收
已经有10人回复
-
各位老师好，我的一志愿为北京科技大学085601材料专硕
已经有5人回复
-
一志愿太原理工安全工程300分，求调剂
已经有6人回复
-
0856求调剂
已经有4人回复
-
11408软件工程求调剂
已经有3人回复
-
一志愿211 初试270分 求调剂
已经有8人回复
-
300求调剂，材料科学英一数二
已经有6人回复
-
学硕274求调剂
已经有9人回复
-
本科双非材料，跨考一志愿华电085801电气，283求调剂，任何专业都可以
已经有7人回复
-
317分 一志愿南理工材料工程 本科湖工大 求调剂
已经有7人回复
» 抢金币啦！回帖就可以得到:
-
西安征结婚女友
+1/288
-
五邑大学池振国教授团队2026年大量接收化学化工材料背景考研生
+5/110
-
求助紫外可见分光光度计
+1/99
-
天津科技大学-（新晋院士团队）先进纤维与纸基功能材料团队B+专业
+1/93
-
求助有机化学第二版陆阳申东升主编课件或者电子版书籍
+1/84
-
招收2026级环境科学方向（专业代码083001）硕士研究生1-2名
+1/37
-
福建农林大学材料院招收调剂硕士生
+1/37
-
浙江省人民医院博士后岗位招聘
+1/36
-
三峡大学材化学院李东升校长团队接收化学类硕士调剂
+1/21
-
双一流大学湘潭大学“化工过程模拟与强化”国家地方联合工程研究中心招收各类博士生
+1/16
-
电子信息求调剂
+1/10
-
三峡大学材化学院能源环保晶态材料课题组接收调剂，招收化学类硕士
+1/10
-
化学、化工、化妆品、材料背景考生调剂
+1/7
-
香港中文大学（深圳）张舵课题组招生-高分子功能材料、智能/仿生材料、生物材料方向
+1/7
-
欢迎调剂报考
+1/6
-
计算机(11408)考研361分求调剂
+1/4
-
基于机器学习和人工智能的结构/合金设计-西安交大
+1/4
-
长江师范学院化学化工学院2026年硕士研究生接收调剂的通知
+1/4
-
北京高校副校长团队招收机械类，环境类学硕和专硕
+1/4
-
天津医科大学基础医学院张恒课题组博士后招聘
+1/3
5楼2011-03-07 17:18:26
wjmsicuan(金币+1, 翻译EPI+1): 很差劲，不过还是慰问下！！ 2011-03-06 19:43:10
 在1957年，Jacobson 等人对大鼠首先进行双侧肾切除，之后放血或用钴处理，发现Ep不增高，然而，如果预先只是将大鼠输尿管结扎，其血液尿素含量增高，之后放血或用钴处理，其Ep，和正常鼠一样，增高。在小鼠，家兔，狒狒和狗身上做相同的实验，获得的结果相似。在人群中，伴有严重尿毒症的白血病患者的血液Ep水平较低，但在肾移植手术成功后，血液Ep水平升高，且血细胞计数也有所增加。此外，对分离的家兔的肾灌流液，即体外培养的肾细胞的红血球生成活性进行检测。虽然支持Ep 来源于肾的证据可靠，但直到现在，人们还没能从正常的肾或不同的肾fractions提取出 Ep 。为了解释这个难题，三个不同的假说被提出。最新证据显示，由组织缺氧和局部缺血诱导的 Ep的产生是通过上调肾脏前列腺素和cAMP水平来介导的。用cAMP处理多血症小鼠可增加Ep的产生，处理正常小鼠可导致红细胞块的增加。前列腺可以上调体外灌流的狗肾脏的cAMP浓度，同时也可以上调灌流液中Ep含量。用前列腺素处理红细胞增多小鼠，可以增加血液前列腺素E含量，也可以增加狗的血Ep含量。对这2个参数的影响和组织缺氧诱导的Ep增多可以被消炎药茚甲新阻断，茚甲新是前列腺素合成的抑制剂。由于前列腺素主要分布于肾髓，而Ep已通过荧光抗体被鉴定存在于肾皮质， 这些观察结果与假设一致，即肾缺氧或缺血诱导肾髓释放前列腺素，而前列腺素反过来又上调肾皮质的cAMP浓度。新生成的cAMP，接下来可能可以激活蛋白激酶增加Ep的产生，很可能是通过磷酸化肾红血球生成因子前体来实现的。 虽然肾是控制Ep生成的主要场所，在大多数物种经历双肾切除手术之后，激素和红血球产生过程仍然继续，只是以相当低的速度。无肾小鼠和无肾大鼠在缺氧条件下仍然保留约10%生产Ep的能力,但无肾的病人，常表现为严重贫血，在血浆中含有Ep。大鼠肾外的Ep和肾来源的Ep很相似，也可以刺激骨髓细胞生成亚铁血红素，可以被抗尿Ep的抗血清中和。一些研究团队认为肝脏是肾外Ep产生的最初部位。在胎儿期 Ep主要在肝脏中产生。在无肾大鼠中，肝脏切除可以阻断低氧诱导激素的产生，但在有完整肾的动物中肝脏切除不可阻断。在部分肝脏切除的大鼠中， 肾外Ep对低氧的反应直接与肝再生相关，且在增殖最旺盛期肾外Ep增加最快。 用胶状碳或酵母聚糖诱导肝网状内皮组织增生，可以促进受低氧胁迫的肾切除大鼠的Ep的产生。这个效应同样可以被肝切除手术阻断，提示肝网状内皮系统 可能是肾外Ep产生的重要因素。 第一次翻译，凑活着看啊 |
2楼2011-03-05 20:56:56
3楼2011-03-05 21:04:18
4楼2011-03-06 21:18:12
