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第一句:In order to determination of lamivudine and its related substances by HPLC and study the structure-activity relationships of oxathiolanyl nucleosides as potential anti-virus agents, the synthesis geometrical isomer cis-(±) 1 and trans-(±) 2 of lamivudine was needed. 第二句:The mixture was separated by silica gel column chromatography using EtOAc/MeOH (50:1) as eluant to achieved 8 in 58% yield as the slow moving component7 and 9 in 25% yield as the fast moving product8 (Lit.5 8 and 9 combined yield 55.3%). Deprotection of 8 and 9 using NH4OH in EtOH at room temperation produced the desired cis-(±) 19 and trans-(±) 210 in 84.7% and 92.5% yield, respectively. 上下文参考可以看我要翻译的整篇的文献https://www.rayfile.com/zh-cn/fi ... -a0af-0015c55db73d/ |
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2楼2011-03-02 12:21:11
3楼2011-03-02 12:22:44
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In order to(个人觉得这个句子由错误,应该用FOR) determination of lamivudine and its related substances by HPLC and study the structure-activity relationships of oxathiolanyl nucleosides as potential anti-virus agents, the synthesis geometrical isomer cis-(±) 1 and trans-(±) 2 of lamivudine was needed. 为了通过HPLC检测拉米夫定及与此相关的物质以及研究氧硫杂环戊基核苷作为抗病毒药剂的构效关系(SAR),我们需要合成拉米夫定的正式同分异构体。 |
4楼2011-03-02 12:26:41
5楼2011-03-02 12:29:59









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