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1£©Another study suggested higher adsorption of fibronectin on hydrophilic SAMs£¨×Ô×é×°£© surfaces with greater focal adhesion formation (integrin binding) evident in the osteoblast cells adhered to the hydrophilic SAM treated surfaces


2£©He found that the spacing among the nanofeatures modulates focal adhesion (FA) formation; cells cultured on a 58 nm nanopattern formed normal FA, whereas those plated on a 108 nm nanopattern failed to develop FA.


3£©Geometrical constraints imposed by topographic features smaller than focal adhesion architecture (approximately 300 nm) actually confine the cell attachment apparatus to the top of the topographic feature. Therefore, on the nanoscale patterns, integrin occupancy within a focal adhesion may be spatially segregated whereas on microscale ridges there are no constraints on integrin¨Cligand binding.


[ Last edited by alps1999 on 2011-1-9 at 10:59 ]

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2£©He found that the spacing among the nanofeatures modulates focal adhesion (FA) formation; cells cultured on a 58 nm nanopattern formed normal FA, whereas those plated on a 108 nm nanopattern failed to develop FA.
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imposed £¨¶¨Óby topographic features smaller than focal adhesion architecture (approximately 300 nm)
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Therefore, on the nanoscale patterns, integrin occupancy within a focal adhesion may be spatially segregated .
whereas £¬
on microscale ridges there are no constraints on integrin¨Cligand binding.
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