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This hypothesis is further supported by the finding that immunization of cattle with A.marginale derived from infected erythrocytes in which MSP1a is upregulated with respect to MSP1b and probably exists uncoupled to MSP1b, provided a level of protection comparable to that observed in cattle immunized with recombinant MSP1a and A. marginale derived from infected tick cells, in which MSP1a is downregulated and most likely exists only in the MSP1 complex with MSP1b.
Another factor to be considered for the induction of a protective immune response against A. marginale is the role of sugar moieties of MSP1a in the protection properties, which may also contribute to the generation of a neutralizing response in cattle.
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da_da(½ð±Ò+8, ·­ÒëEPI+1): 2011-01-08 11:23:07
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