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[交流] 【求助/交流】中心法则

随着表观生物学和非编码RNA的研究进展，许多人认为中心法则已经过时了，请谈一下你对此观点的看法。

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1楼 2010-12-21 14:35:26

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

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不就是DNA、RNA、蛋白质倒来倒去，这也称得上法则
central dogma就直接翻译成中心，也太直接了

Use of the term "dogma"
In his autobiography, What Mad Pursuit, Crick wrote about his choice of the word dogma and some of the problems it caused him:
I called this idea the central dogma, for two reasons, I suspect. I had already used the obvious word hypothesis in the sequence hypothesis, and in addition I wanted to suggest that this new assumption was more central and more powerful. ... As it turned out, the use of the word dogma caused almost more trouble than it was worth.... Many years later Jacques Monod pointed out to me that I did not appear to understand the correct use of the word dogma, which is a belief that cannot be doubted. I did apprehend this in a vague sort of way but since I thought that all religious beliefs were without foundation, I used the word the way I myself thought about it, not as most of the world does, and simply applied it to a grand hypothesis that, however plausible, had little direct experimental support.
Similarly, Horace Freeland Judson records in The Eighth Day of Creation:
"My mind was, that a dogma was an idea for which there was no reasonable evidence. You see?!" And Crick gave a roar of delight. "I just didn't know what dogma meant. And I could just as well have called it the 'Central Hypothesis,' or — you know. Which is what I meant to say. Dogma was just a catch phrase."
http://en.wikipedia.org/wiki/Central_dogma_of_molecular_biology

[ Last edited by 602059625 on 2010-12-30 at 19:07 ]