| 查看: 927 | 回复: 3 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
求把这段英文翻译成日文
|
|||
|
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer’s disease. Formation of amyloid-beta is catalysed by gamma-secretase, a protease with numerous substrates. Little is known about the molecular mechanisms that confer substrate specificity on this potentially promiscuous enzyme. Knowledge of the mechanisms underlying its selectivity is critical for the development of clinically effective gamma-secretase inhibitors that can reduce amyloid-beta formation without impairing cleavage of other gamma-secretase substrates, especially Notch, which is essential for normal biological functions. Here we report the discovery of a novel gamma-secretase activating protein (GSAP) that drastically and selectively increases amyloid-beta production through a mechanism involving its interactions with both gamma-secretase and its substrate, the amyloid precursor protein carboxy-terminal fragment (APP-CTF). GSAP does not interact with Notch, nor does it affect its cleavage. Recombinant GSAP stimulates amyloid-beta production in vitro. Reducing GSAP concentrations in cell lines decreases amyloid-beta concentrations. Knockdown of GSAP in a mouse model of Alzheimer’s disease reduces levels of amyloid-b and plaque development. GSAP represents a type of gamma-secretase regulator that directs enzyme specificity by interacting with a specific substrate.We demonstrate that imatinib, an anticancer drug previously found to inhibit amyloid-beta formation without affecting Notch cleavage, achieves its amyloid-beta-lowering effect by preventing GSAP interaction with the gamma-secretase substrate, APP-CTF. Thus, GSAP can serve as an amyloid-beta-lowering therapeutic target without affecting other key functions of gamma-secretase. |
回复此楼» 猜你喜欢
澳大利亚 Murdoch University 全奖博士招生（3个名额）地质化工冶金领域
已经有80人回复
-
欢迎发来filecode的Mz6后的代码验证其规律
已经有36人回复
-
FileCode能看出啥？
已经有32人回复
-
咱们一起用铁证分析2026国家社科基金中标与否
已经有12人回复
-
我的国基提前知道中了，可是同事的操作让我实在接受不了，怎么会有这样的人
已经有15人回复
-
关于Filecode分析方法
已经有12人回复
-
小木虫上这么多卖论文的，真有人买论文么？感觉没必要啊
已经有10人回复
-
阿姨
已经有4人回复
-
一作与独作在应聘高校教师时区别大吗
已经有4人回复
-
静等基金结果
已经有21人回复
» 抢金币啦！回帖就可以得到:
-
2026年生物学、大数据与信息工程国际会议 (BSBIE 2026)
+1/340
-
真诚找女友
+1/180
-
东南大学杰青/海优团队招聘催化方向博士后
+1/94
-
东南大学杰青/海优团队招聘催化方向博士后
+1/91
-
中国科学院空天院精密干涉测量团队招聘光学/算法/机械方向博士后/特别研究助理
+1/85
-
广东医科大学博士后招聘-基础医学，生信等方向
+1/38
-
物理学报录用，散币感谢合作者和审稿人
+2/34
-
请问谁有2025最新影响因子Excel表？金币求助！
+1/27
-
哈工大（深圳）何自开团队诚招化学工程与技术专业博士生
+1/24
-
论文祈福
+1/12
-
硕士毕业9年的我，读博的想法日益强烈。。。。
+1/9
-
同济大学环境学院肖倩课题组2026年补充招收推免生
+1/6
-
关于Ghaffar-Parkins催化剂催化氰基水解为酰胺的问题
+1/6
-
西北大学欧阳湘元课题组（国家优青）招收27年化学博士
+1/5
-
海南大学化学院-科研助理招聘 （可读博，可与华中科技大学，天津大学联培）+博后招聘
+1/4
-
北理工集成电路杰青团队 | 诚招科助理
+1/4
-
UTS 招收2027年入学博士生
+1/4
-
中山大学计算数学方向招2027届考核制博士生
+1/3
-
海南大学化学院—功能分子器件团队2027博士招生+博士后招聘
+1/3
-
中国科学技术大学环境学院招聘招生
+1/2
4楼2010-12-03 08:39:02
★
ringzhu(金币-1):本版严禁机器翻译 下不为例。。。。 2010-12-07 10:50:42
ringzhu(金币-1):本版严禁机器翻译 下不为例。。。。 2010-12-07 10:50:42
|
??U????????????¤???e????????????? ?????????`?????????????¤??γ???????????? ??-???????`?????????λ??|????????`????????????????? ???|???????????????????????? ??????????e??????????????R ?????x?k?Υ?????????_?k?Τ???η?????????? ?R????????????-???????`???躦???Τ?????p?餹??????????? ???Φ?-???????`???Γp????ж??????????????¤??γ? ???塢????????郎?????????????Υ???? ?C?????????????????¤????-???????`????k????椹?? ???????|??GSAP??????????x?k??ˉ?????????? ?C????餷??????????¤????b??????????????? ?I???Φ?-???????`??????λ??|?????????????l?? ?????|?Υ????????????????APP - CTF????? GSAP?????? ??????Υ???????????????ж?????????????z????M?Q?? GSAP?????Y??????????????b?????????? GSAP??p?餹 ????????????????????-????????¤????? ?????????`???Υ?????????GSAP?ΥΥ???????? ?????????- b????`?????_?k?Υ?????p??????? GSAP????? ?????????????????-???????`???????`???Υ????? ???Υ???????????????λ????????????????? ?????????????????????¤??γ???躦??????? ?Υ?????ж?????????????g?F?Υ????????¤???¤????? ??-???????`?????|??GSAP?????????????????????? ??APP - CTF?Ρ???????????GSAP?褦??????????????????????-??-??????? ??-???????`?????????????C????????????????`????????? |
2楼2010-12-02 14:20:51
3楼2010-12-02 15:01:20
