24小时热门版块排行榜

返回列表

liujunjunp

木虫 (小有名气)

应助: 0 (幼儿园)
金币: 5625.4
帖子: 280
在线: 81.6小时
虫号: 678222

[交流] 求把这段英文翻译成日文

Accumulation of neurotoxic amyloid-beta is a major hallmark of
Alzheimer’s disease. Formation of amyloid-beta is catalysed by
gamma-secretase, a protease with numerous substrates. Little is known
about the molecular mechanisms that confer substrate specificity
on this potentially promiscuous enzyme. Knowledge of the
mechanisms underlying its selectivity is critical for the development
of clinically effective gamma-secretase inhibitors that can reduce
amyloid-beta formation without impairing cleavage of other gamma-secretase
substrates, especially Notch, which is essential for normal biological
functions. Here we report the discovery of a novel gamma-secretase
activating protein (GSAP) that drastically and selectively increases
amyloid-beta production through a mechanism involving its interactions
with both gamma-secretase and its substrate, the amyloid precursor
protein carboxy-terminal fragment (APP-CTF). GSAP does not
interact with Notch, nor does it affect its cleavage. Recombinant
GSAP stimulates amyloid-beta production in vitro. Reducing GSAP
concentrations in cell lines decreases amyloid-beta concentrations.
Knockdown of GSAP in a mouse model of Alzheimer’s disease
reduces levels of amyloid-b and plaque development. GSAP represents
a type of gamma-secretase regulator that directs enzyme specificity by
interacting with a specific substrate.We demonstrate that imatinib,
an anticancer drug previously found to inhibit amyloid-beta formation
without affecting Notch cleavage, achieves its amyloid-beta-lowering
effect by preventing GSAP interaction with the gamma-secretase substrate,
APP-CTF. Thus, GSAP can serve as an amyloid-beta-lowering therapeutic
target without affecting other key functions of gamma-secretase.

回复此楼

» 猜你喜欢

面上没中，邀请各位路过的虫友分析一下分数已经有10人回复
售SCI一区T0P文章，我:8O.55.1.O.54,科目全,可伽急已经有9人回复
广西大学-广州大学招聘博士后欢迎广大优秀人才！！！已经有6人回复
两块石头已经有5人回复
哈尔滨工业大学韩晓军教授课题组招收2027年硕士推免生及博士研究生已经有3人回复
找导师已经有8人回复
国社科又开始会评了，不知道这次命运如何已经有14人回复
科研人应该花精力去思考如何解决问题，而不是去凝练问题已经有14人回复
要骂人了，新模版改版就是要淡化问题凝练这种虚的东西，结果有个评委还在说凝练得不够已经有17人回复
学科评审组评审是指会评吗？已经有5人回复

» 抢金币啦！回帖就可以得到:

查看全部散金贴

1楼 2010-11-27 22:49:44

已阅关注TA 给TA发消息送TA红花 TA的回帖

bibiaomian

金虫 (著名写手)

翻译EPI: 1
应助: 0 (幼儿园)
金币: 403
帖子: 1153
在线: 124.7小时
虫号: 1136353

★
ringzhu(金币-1):本版严禁机器翻译下不为例。。。。 2010-12-07 10:50:42

??U????????????¤???e?????????????
?????????`?????????????¤??γ????????????
??-???????`?????????λ??|????????`?????????????????
???|????????????????????????
??????????e??????????????R
?????x?k?Υ?????????_?k?Τ???η??????????
?R????????????-???????`???躦???Τ?????p?餹???????????
???Φ?-???????`???Γp????ж??????????????¤??γ?
???塢????????郎?????????????Υ????
?C?????????????????¤????-???????`????k????椹??
???????|??GSAP??????????x?k??ˉ??????????
?C????餷??????????¤????b???????????????
?I???Φ?-???????`??????λ??|?????????????l??
?????|?Υ????????????????APP - CTF????? GSAP??????
??????Υ???????????????ж?????????????z????M?Q??
GSAP?????Y??????????????b?????????? GSAP??p?餹
????????????????????-????????¤?????
?????????`???Υ?????????GSAP?ΥΥ????????
?????????- b????`?????_?k?Υ?????p??????? GSAP?????
?????????????????-???????`???????`???Υ?????
???Υ???????????????λ?????????????????
?????????????????????¤??γ???躦???????
?Υ?????ж?????????????g?F?Υ????????¤???¤?????
??-???????`?????|??GSAP??????????????????????
??APP - CTF?Ρ???????????GSAP?褦??????????????????????-??-???????
??-???????`?????????????C????????????????`?????????