| 查看: 919 | 回复: 3 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
求把这段英文翻译成日文
|
|||
|
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer’s disease. Formation of amyloid-beta is catalysed by gamma-secretase, a protease with numerous substrates. Little is known about the molecular mechanisms that confer substrate specificity on this potentially promiscuous enzyme. Knowledge of the mechanisms underlying its selectivity is critical for the development of clinically effective gamma-secretase inhibitors that can reduce amyloid-beta formation without impairing cleavage of other gamma-secretase substrates, especially Notch, which is essential for normal biological functions. Here we report the discovery of a novel gamma-secretase activating protein (GSAP) that drastically and selectively increases amyloid-beta production through a mechanism involving its interactions with both gamma-secretase and its substrate, the amyloid precursor protein carboxy-terminal fragment (APP-CTF). GSAP does not interact with Notch, nor does it affect its cleavage. Recombinant GSAP stimulates amyloid-beta production in vitro. Reducing GSAP concentrations in cell lines decreases amyloid-beta concentrations. Knockdown of GSAP in a mouse model of Alzheimer’s disease reduces levels of amyloid-b and plaque development. GSAP represents a type of gamma-secretase regulator that directs enzyme specificity by interacting with a specific substrate.We demonstrate that imatinib, an anticancer drug previously found to inhibit amyloid-beta formation without affecting Notch cleavage, achieves its amyloid-beta-lowering effect by preventing GSAP interaction with the gamma-secretase substrate, APP-CTF. Thus, GSAP can serve as an amyloid-beta-lowering therapeutic target without affecting other key functions of gamma-secretase. |
回复此楼» 猜你喜欢
综述论文作为代表作会不会影响评审专家的印象分？
已经有12人回复
-
2019年青年基金涵评意见，大家看看几个A，几个B?
已经有4人回复
-
应该是93bebmhtak前后十一个字符比较关键
已经有29人回复
-
奇怪，两个人的filecode固定段从头到尾一模一样
已经有9人回复
-
是这周出结果还是下周出结果？
已经有3人回复
-
小木虫上这么多卖论文的，真有人买论文么？感觉没必要啊
已经有9人回复
-
有时候，自然基金真的不能太认真 （我的申报经验）
已经有4人回复
-
帮忙看看fileCode
已经有13人回复
-
为什么网上很多人说本周 12号出结果
已经有7人回复
-
读博的好处
已经有3人回复
» 抢金币啦！回帖就可以得到:
-
北京理工大学集成电路学院-柔性电子器件与智造研究所-2027级博士招生
+1/468
-
上海男征女 条件优秀可加微信联系
+1/452
-
胆酸锂 （Lithium cholate）
+1/88
-
香港理工大学PhD/RA/PostDoc in OR/AI/OM
+1/82
-
招收本科/研究生实习生（2026年9月开始可以长期实习）
+1/82
-
中国科学技术大学-苏州国家实验室联培招生-本科直博/硕博连读/申请考核三种方式
+1/79
-
香港城市大学郑星课题组诚聘博士后 (生态学、环境科学、植物学、大气科学背景)
+1/78
-
实验室富余
+1/73
-
北京理工大学光电学院拟神经计算器件方向，2027级博士/硕士招生
+1/38
-
【坐标北京，诚征男友，结婚对象】
+5/37
-
天津大学环境学院童银栋教授招收博士后（生源要素循环/温室效应/新污染物方向）
+1/33
-
哈工大（深圳）何自开团队诚招2027级化学工程与技术专业博士生
+1/26
-
中国石油大学（华东）材料科学与工程学院/新颖能源材料智能设计和开发方向 特聘副教授
+2/21
-
南京航空航天大学招收27年力学硕士和博士生研究生
+1/14
-
中科院理化所热声热机团队招聘电气工程专业(电机方向)博士后/特别研究助理
+1/14
-
高耐腐蚀性的镁合金微弧氧化工艺
+1/12
-
北京理工大学-集成电路与电子学院杰青团队-招博士后
+1/9
-
希望大家都高中！！
+1/7
-
国家级人才团队诚聘生物信息相关专业的科研助理
+1/7
-
香港理工大学殷骏课题组诚聘1 名博士后以及2 名博士生
+1/4
3楼2010-12-02 15:01:20
★
ringzhu(金币-1):本版严禁机器翻译 下不为例。。。。 2010-12-07 10:50:42
ringzhu(金币-1):本版严禁机器翻译 下不为例。。。。 2010-12-07 10:50:42
|
??U????????????¤???e????????????? ?????????`?????????????¤??γ???????????? ??-???????`?????????λ??|????????`????????????????? ???|???????????????????????? ??????????e??????????????R ?????x?k?Υ?????????_?k?Τ???η?????????? ?R????????????-???????`???躦???Τ?????p?餹??????????? ???Φ?-???????`???Γp????ж??????????????¤??γ? ???塢????????郎?????????????Υ???? ?C?????????????????¤????-???????`????k????椹?? ???????|??GSAP??????????x?k??ˉ?????????? ?C????餷??????????¤????b??????????????? ?I???Φ?-???????`??????λ??|?????????????l?? ?????|?Υ????????????????APP - CTF????? GSAP?????? ??????Υ???????????????ж?????????????z????M?Q?? GSAP?????Y??????????????b?????????? GSAP??p?餹 ????????????????????-????????¤????? ?????????`???Υ?????????GSAP?ΥΥ???????? ?????????- b????`?????_?k?Υ?????p??????? GSAP????? ?????????????????-???????`???????`???Υ????? ???Υ???????????????λ????????????????? ?????????????????????¤??γ???躦??????? ?Υ?????ж?????????????g?F?Υ????????¤???¤????? ??-???????`?????|??GSAP?????????????????????? ??APP - CTF?Ρ???????????GSAP?褦??????????????????????-??-??????? ??-???????`?????????????C????????????????`????????? |
2楼2010-12-02 14:20:51
4楼2010-12-03 08:39:02
