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Through the supplementary material allocated proportion experiment, to determine the prescription of Xiangshayangwei soft capsule, compress the suspension which is made from extraction and auxiliary materials into soft capsules. Each capsule contains the total of magnolol and honokiol not less than 1.0 mg. The ratio of gelatin and glycerin, water and gelatin in the proportion of melt temperature for the investigated factors, the orthogonal test. Take the proportion of gelatin and glycerine , the proportion of water and gelatin, the melt temperature as the inspection factors, carries on the orthogonal test to determine the best form of soft capsule gelatin capsule shell: glycerol: water = 2:1:2, melt temperature 70¡æ.
Using the TLC method as qualitative identification to identify Fructus Amomi, Herba Pogostemonis, Pericarpium Citri Reticulatae and Citrus Aurantium. Using the HPLC method to determine the content of magnolol and honokiol, establishing the linear equations of magnolol and honokiol through external standard method, magnolol RSD 0.38%, average recovery 98.04%; honokiol RSD 1.41%, average recovery 99.00%. The method is simple, reproducible, and can be used as the quality control of Xiangshayangwei soft capsule.
Has carried on the acceleration stability experiment and the long-term stability experiment to the three batches of samples, the stability is good.
In brief, through the study of preparation, quality standard and stability of Xiangshayangwei soft capsule, the reasonable formulation molding process has been optimized, the effective quality control method has been established, the product stability has been improved, all these have provided the theoretical and experimental basis for preparation of the production.

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zhanpeng1982(½ð±Ò+5, ·­ÒëEPI+1): 2010-10-22 02:56:05
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Proportioning experiments of supplementary materials are conducted in order to determine the prescription of Xiangshayangwei soft capsules.  

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2Â¥2010-10-22 01:29:13
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zhanpeng1982

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3Â¥2010-10-22 02:02:38
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Proportioning experiments of supplementary materials are conducted in order to determine the prescription of Xiangshayangwei soft capsules. The soft capsules are manufactured by encapsulating the suspension that is made of the extracted and auxiliary materials. Each capsule contains a total mass of magnolol and honokiol not less than 1.0 mg. In order to determine the optimal composition for capsule shells, orthogonal tests are carried out to explore the effects of the ratio of gelatin to glycerin, the ratio of water to gelatin, and the melt temperature. The observed optimal composition is: gelatin:glycerin:water = 2:1:2, with a melt temperature of 70 deg C.

TLC technique is utilized to identify qualitatively the Fructus Amomi, Herba Pogostemonis, Pericarpium Citri Reticulatae, and Citrus Aurantium. Moreover, the HPLC technique is used to measure the magnolol and honokiol and linear equations of magnolol and honokiol are proposed by using the external standard method. xxxxxx. It is shown that this method is simple and reproducible, that can be used as a quality control route for xxx capsules.

Stability is well exhibited by performing both accelerated and long-term stability tests on three batchs of samples.

In sum, in this study the preparation technique of xxx capsules has been optimized and an effective quality control method has been proposed as well. By doing so, the stability of the product has been shown to be improved, which provides a theoretical and experimental guide for large-scale manufacturing.
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4Â¥2010-10-22 03:02:43
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zhanpeng1982(½ð±Ò+15):·Ç³£µØÐ»Ð»Äã 2010-10-22 03:23:41
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5Â¥2010-10-22 03:03:38
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