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catjaja

金虫 (著名写手)

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[交流] 求翻译一小段，药学专业，英语译成汉语

The enantiomericpuritydeterminationofasyntheticintermediateofnew3,4-dihydro-2,2-dimethyl-2H-
1-benzopyrans, i.e.4-amino-2,2-dimethyl-6-ethoxycarbonylamino-3,4-dihydro-2H-1-benzopyran, was
successfully carriedoutusingananioniccyclodextrin(CD)derivativecombinedwithachiralionic
liquid (IL).Inordertoobtainhighresolutionandefficiencyvalues,theadditionofachiralIL,i.e.
ethylcholine bis(trifluoromethylsulfonyl)imide(EtCholNTf2), tothebackgroundelectrolytecontain-
ing heptakis(2,3-di-O-methyl-6-O-sulfo)--CD (HDMS--CD) wasfoundtobeessential.Asimultaneous
increase inseparationselectivityandenantioresolutionseemstoindicateasynergisticeffectofHDMS--
CD andEtCholNTf2. Thebestenantioseparationofthekeyintermediatewasachievedusingamethanolic
solution of0.75Mformicacid,10mMammoniumformate,1.5mMHDMS--CD and5mMEtCholNTf2.
Levamisole wasselectedasinternalstandard.Theoptimizedconditionsallowedthedeterminationof
0.1% ofeachenantiomerinthepresenceofitsstereoisomerusingthemethodofstandardadditions.The
NACE methodwasthenfullyvalidatedwithrespecttoselectivity,responsefunction,trueness,precision,accuracy, linearityandlimitsofdetectionandquantification.

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3323的马甲

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专业: 天然药物化学

The enantiomeric purity determination of a synthetic intermediate of new 3,4-dihydro-2,2-dimethyl-2H-
1-benzopyrans, i.e.4-amino-2,2-dimethyl-6-ethoxycarbonylamino-3,4-dihydro-2H-1-benzopyran, was
successfully carried out using an anionic cyclodextrin(CD) derivative combined with a chiral ionic
liquid (IL).In order to obtain high resolution an defficiency values,the addition of a chiralIL,i.e.
ethylcholine bis(trifluoromethylsulfonyl)imide(EtCholNTf2), to the background electrolytecontain-
ing heptakis(2,3-di-O-methyl-6-O-sulfo)--CD (HDMS--CD) was found to be essential.A simultaneous
increase in separation selectivity andenantioresolution seems to indicate asynergistic effect of HDMS--
CD and EtCholNTf2. The best enantioseparation of the key intermediate was achieved using a methanolic
solution of0.75M formic acid,10mM ammonium formate,1.5mMHDMS--CD and 5mM EtCholNTf2.
Levamisole was selected as internal standard.The optimized conditions allowed the determination of
0.1% of each enantiomer in the presence of its stereoisomer using the method of standard additions.The
NACE method was then fully validated with respect to selectivity,response function,trueness,precision,accuracy,
linearity and limits of detection and quantification.