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chzhbin金虫 (职业作家)
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[交流]
【求助】翻译 很简单
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| 摘要：白黎芦醇(resveratrol,3,4',5—三羟基—二苯乙烯)为多酚类化合物，是一种存在于自然界的植物抗毒素，主要分布在虎杖、花生、葡萄、百合、桑葚等70余种植物中，近年来发现其具有抗菌、抗肿瘤、抗血栓、抗氧化、调节血脂、保护肝脏等多种有益于人体的生物学功能，成为人们关注的焦点，但其天然来源十分有限，且难溶于水,对光热敏感、化学性质不稳定,易被氧化分解,制约了其广泛应用。因此对其合成路线的研究、质量标准及制备成合适剂型以提高生物利用度就显的十分重要，本文以3,5-二甲氧基苯甲醇为原料，经过溴代、Arbuzov重排、wittig-horner缩合、脱甲基四步反应制备白藜芦醇，并根据05版药典规定及制备工艺建立相应的质量标准，针对其化学性质，将其制备成合适的纳米乳制剂并筛选出最佳处方。 |
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zhangzws
金虫 (正式写手)
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7楼2010-08-02 17:17:50
zerohead
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2楼2010-08-02 16:07:52
chzhbin
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3楼2010-08-02 16:48:37
zhangzws
金虫 (正式写手)
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chzhbin(金币+26):非常感谢 呵呵 2010-08-02 17:06:10
| Abstract: Resveratrol (3,4’,5-trihydroxy-toluylene) as polyphenol compounds is a phytoalexin that mainly exists in 70 species of plants in nature which included polygonum cuspidatum, peanut, grape, lily, mulberry and other. Recently, the study found that resveratrol plays a physiological function in antibiotic, antitumor, antithrombotic, antioxidation, regulating blood lipid and the protection of the liver, which results that it becomes the focus of people's attention. However, the limited sources of natural resveratrol as well as its water-insoluble, optothermall-reactivity, poor chemical stability and oxidative decomposition restrict its application. So that the study of its synthetic method, quality standard and synthesis economical problem of crucial importance. In this paper, resveratrol is synthesized using 3,4-dimethoxy-phemethylolas raw material by bromination, Arbuzov rearrangement, wittig-horner condensation and demethylation. Based on the Chinese Pharmacopoeia (2005 edition) and preparation technology, the corresponding quality standards were built. In addition, based on its chemical properties, proper resveratrol nano-emulsion was prepared, and the optimal preparation process was screened out. |
4楼2010-08-02 16:56:43
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