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【求助】哪位能帮忙查个USP33上的药物
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| 哪位能帮忙查个USP33上的药物？ |
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nkbeholder
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houhou1986
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笨笨猪0608(金币+1):谢谢参与 2010-03-04 08:31
笨笨猪0608(金币+1):谢谢参与 2010-03-04 08:31
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http://ishare.iask.sina.com.cn/f/6297627.html 去这里看看USP33-NF28总论部分 |
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6楼2010-03-13 10:30:38
gubangjin
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Monograph Number: 0000864 Title: Atorvastatin CAS Registry Number: 134523-00-5 CAS Name: (bR,dR)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid Molecular Formula: C33H35FN2O5 Molecular Weight: 558.64 Percent Composition: C 70.95%, H 6.31%, F 3.40%, N 5.01%, O 14.32% Literature References: HMG-CoA reductase inhibitor. Prepn: B. D. Roth, EP 409281; idem, US 5273995 (1991, 1993 both to Warner-Lambert); K. L. Baumann et al., Tetrahedron Lett. 33, 2283 (1992). Solubility and kinetic studies: A. S. Kearney et al., Pharm. Res. 10, 1461 (1993). LC/MS/MS determn in serum: M. Jemal et al., Rapid Commun. Mass Spectrom. 13, 1003 (1999). Clinical pharmacokinetics: D. D. Cilla, Jr. et al., Clin. Pharmacol. Ther. 60, 687 (1996). Review of pharmacology and clinical experience: H. S. Yee, N. T. Fong, Ann. Pharmacother. 32, 1030-1043 (1998); of efficacy in diabetic patients: K. F. Croom, G. L. Plosker, Drugs 65, 137-152 (2005). Derivative Type: Calcium salt trihydrate CAS Registry Number: 344423-98-9; 134523-03-8 (anhydrous) Manufacturers' Codes: CI-981 Trademarks: Lipitor (Parke-Davis); Sortis (Pfizer); Torvast (Pfizer); Totalip (Guidotti) Molecular Formula: C66H68CaF2N4O10.3H2O Molecular Weight: 1209.39 Percent Composition: C 65.55%, H 6.17%, Ca 3.31%, F 3.14%, N 4.63%, O 17.20% Properties: White to off-white crystalline powder. [a]D -7.4° (c = 1 in DMSO). Freely sol in methanol; slightly sol in ethanol; very slightly sol in acetonitrile, distilled water, phosphate buffer (pH 7.4). Insol in aq solns of pH 4 and below. Optical Rotation: [a]D -7.4° (c = 1 in DMSO) Derivative Type: Sodium salt CAS Registry Number: 134523-01-6 Molecular Formula: C33H34FN2NaO5 Molecular Weight: 580.62 Percent Composition: C 68.26%, H 5.90%, F 3.27%, N 4.82%, Na 3.96%, O 13.78% Properties: pKa 4.46. Soly in water (30°): 20.4 mg/ml (pH 2.1); 1.23 mg/ml (pH 6.0). pKa: pKa 4.46 Derivative Type: Lactone CAS Registry Number: 125995-03-1 CAS Name: 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide Molecular Formula: C33H33FN2O4 Molecular Weight: 540.62 Percent Composition: C 73.31%, H 6.15%, F 3.51%, N 5.18%, O 11.84% Properties: mp 159.2-160.7°. [a]D +26.05° (c = 1 in chloroform). Melting point: mp 159.2-160.7° Optical Rotation: [a]D +26.05° (c = 1 in chloroform) Therap-Cat: Antilipemic. Keywords: Antilipemic; HMG CoA Reductase Inhibitors; HMG CoA Reductase Inhibitor. |
7楼2010-03-14 22:24:20
