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sc-zsc

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[交流] 【求助】确定控制一颜色性状的基因型已有1人参与

现在有两亲本（P1：绿色，P2：黑色，数量足够多且为一种基因型），现在要做的是通过正反交、杂交及回交等手段后代的表现型来推测其位置——细胞质或细胞核，并不是要精确到ＤＮＡ分子上的位置。另外，还要能推测是几对基因控制的——一对、两对或多对。所以不用到分子方面，就是遗传方面简单的问题。我在这方面就一“菜鸟”，希望能有高手指点一下，或给点类似方面的资料。先行谢过！注：最好的至少10个金币，其余的视情况给。

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1楼 2009-12-27 23:24:43

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

zwdbordeaux

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★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
seamuse(金币+2,VIP+0):感谢交流讨论！ 12-28 20:59
sc-zsc(金币+13,VIP+0):谢谢 1-8 08:02

呵呵，这个问题应该是一个基础的遗传学方面的问题。我对遗传虽然略懂一二，但是没有具体的实践经验，所以在此不说自己的见解。
推荐给你一篇文章吧，是关于三文鱼肉颜色遗传的。三文鱼的颜色有两种红色和白色，然后他们通过你提到的方法，确定了有几个基因位点和几个等位基因控制的问题。希望对你有所帮助。
When Parameters in Dynamic Models Become Phenotypes: A Case Study on Flesh Pigmentation in the Chinook Salmon (Oncorhynchus tshawytscha)

http://www.genetics.org/cgi/content/full/179/2/1113

你可以先看看摘要，如果感兴趣可以接着看全文：
The Pacific chinook salmon occurs as both white- and red-fleshed populations, with the flesh color type (red or white) seemingly under strong genetic influence. Previously published data on crosses between red- and white-fleshed individuals cannot be reconciled with a simple Mendelian two-locus, two-allele model, pointing to either a more complex inheritance pattern or the existence of gene interactions. Here we show that a standard single-locus, three-allele model can fully explain these data. Moreover, by implementing the single-locus model at the parameter level of a previously developed mathematical model describing carotenoid dynamics in salmon, we show that variation at a single gene involved in the muscle uptake of carotenoids is able to explain the available data. This illustrates how such a combined approach can generate biological understanding that would not be possible in a classical population genetic explanatory structure. An additional asset of this approach is that by allowing parameters to become phenotypes obeying a given genetic model, biological interpretations of mechanisms involved at a resolution level far beyond what is built into the original dynamic model are made possible. These insights can in turn be exploited in experimental studies as well as in construction of more detailed models.

[ Last edited by zwdbordeaux on 2009-12-28 at 20:35 ]