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ÏÂÃæÊÇÒâ¼û£ºDear Dr. *:

Thank you for submitting your manuscript for publication in The Journal of Physical Chemistry. It has been examined by expert reviewers whose reviews are enclosed. After careful consideration of their comments (and my own evaluation of the manuscript), I am unable to accept the manuscript for publication in The Journal of Physical Chemistry. While one review is positve, the other review points out serious objections which make the article unacceptable.

While your work appears to have been carried out with care, unfortunately, we are unable to accept all of the sound work submitted to the journal. We appreciate your choice of The Journal of Physical Chemistry as a possible forum for presentation of your work.

With sincere regards,

Prof. James Lisy
Senior Editor
The Journal of Physical Chemistry
Phone: 217-265-4091
Fax: 202-513-8763
Editor Email: jpc@scs.uiuc.edu

------------------------------------

Reviewer(s)' Comments to Author:

Reviewer: 1

Recommendation: This paper is not recommended because the material is not appropriate for the Journal of Physical Chemistry.

Comments:

  Thank you for your invitation to review this paper.
  After careful reviewing, I think that this paper cannot be accepted for publication in this journal of "JPC", because it doesnot meet the high standard of JPC. In this paper, the authors hope to prepare the thermo-sensitive drug delivery system. But according to the results shown in Fig.5 and Fig.6, I think that there is no obvious difference between the in vitro release behavior at 45 centigrade and 25 centigrade. That's to say, the prepared microgel didnot show the thermosensitivity actually.
   And I think that PNIPAAM has been studied in many references. The novelty of the manuscript is also very poor.
   So, I think that this paper cannot be accepted for publication.


Additional Questions:

Reviewer: 2

Recommendation: This paper is publishable subject to minor revisions noted.  Further review is not needed.

Comments:
This is one of the series works of authors about thermo-sensitive poly(N-isopropylacrylamide)/mesoporous silica nanocomposites and the application in controlled drug release. In this manuscript, the authors compared the release behavior of model drug ibuprofen from the nanocomposites. The results clearly indicated the function of thermo-sensitive polymer in nanocomposites for drug release. Therefore, this work is suitable for the publication in J. Phys. Chem. C. One question is about the loading of IBU. The author used hexane as loading medium in the present work. In hexane, PNIPAM isn¡¯t  a thermo-sensitive polymer. It should be re-explained about the loading of IBU.
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