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各位大叔大婶，兄弟姐妹们帮帮忙，本人急需以下物质合成文献： 盐酸氯米帕明（CAS号：17321-77-6），异丙安替比林（CAS号：479-92-5），盐酸替利定（CAS号：27107-79-5） 谢谢  |
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2楼2009-10-30 22:16:00
3楼2009-10-30 23:11:53
wjy82
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4楼2009-10-31 08:49:33
5楼2009-10-31 09:19:01
fdaedqm
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kidant(金币+1,VIP+0):谢谢提供帮助 10-31 10:23
isee2009(金币+1,VIP+0): 11-1 16:25
kidant(金币+1,VIP+0):谢谢提供帮助 10-31 10:23
isee2009(金币+1,VIP+0): 11-1 16:25
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Title: Clomipramine CAS Registry Number: 303-49-1 CAS Name: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine Additional Names: 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine; 5-(g-dimethylaminopropyl)-3-chloroiminodibenzyl; chlorimipramine Manufacturers' Codes: G-34586 Molecular Formula: C19H23ClN2 Molecular Weight: 314.85 Percent Composition: C 72.48%, H 7.36%, Cl 11.26%, N 8.90% Literature References: Serotonin reuptake inhibitor. Prepn: P. N. Craig et al., J. Org. Chem. 26, 135 (1961); W. Schindler, H. Dietrich, CH 371799; eidem, US 3467650 (1963, 1969 both to Geigy). Crystal and molecular structure of the hydrochloride: M. L. Post, A. S. Horn, Acta Crystallogr. 33B, 2590 (1977). HPLC determn in serum: H. Weigmann et al., J. Chromatogr. B 710, 227 (1998). Veterinary trial in canine compulsive disorder: C. J. Hewson et al., J. Am. Vet. Med. Assoc. 213, 1760 (1998); in canine separation anxiety: S. Petit et al., Rev. Med. Vet. 150, 133 (1999). Review of pharmacology and clinical experience in obsessive-compulsive disorder and depression: M. D. Peters et al., Clin. Pharm. 9, 165-178 (1990). Properties: bp0.3 160-170°. Boiling point: bp0.3 160-170° Derivative Type: Hydrochloride CAS Registry Number: 17321-77-6 Trademarks: Anafranil (Novartis); Clomicalm (Novartis) Molecular Formula: C19H23ClN2.HCl Molecular Weight: 351.31 Percent Composition: C 64.96%, H 6.89%, Cl 20.18%, N 7.97% Properties: Crystals from acetone-ether/methanol-ether, mp 189-190° (Craig); also reported as crystals from acetone, mp 191.5-192° (Schindler, Dietrich). Freely sol in water, methanol, methylene chloride. Practically insol in ethyl ether, hexane. Melting point: mp 189-190° (Craig); mp 191.5-192° (Schindler, Dietrich) Therap-Cat: Antidepressant; antiobsessional agent. Therap-Cat-Vet: In treatment of canine separation anxiety. Keywords: Antidepressant; Tricyclics; Antiobsessional. |
6楼2009-10-31 10:01:42
fdaedqm
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kidant(金币+1,VIP+0):谢谢提供帮助 10-31 10:23
kidant(金币+1,VIP+0):谢谢提供帮助 10-31 10:23
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Title: Propyphenazone CAS Registry Number: 479-92-5 CAS Name: 1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one Additional Names: 4-isopropylantipyrine; 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 2,3-dimethyl-1-phenyl-4-isopropylpyrazolone; isopropylphenazone Trademarks: Budirol (Fher); Causyth (Inverni); Eufibron (Berlin-Chemie); Isoprochin P (Merckle) Molecular Formula: C14H18N2O Molecular Weight: 230.31 Percent Composition: C 73.01%, H 7.88%, N 12.16%, O 6.95% Literature References: Prepn: Stenz, US 1972036 (1934 to Hoffmann-La Roche); Sawa, J. Pharm. Soc. Jpn. 57, 953 (1937), C.A. 32, 2533 (1938). Properties: Slightly bitter crystals, mp 103°. Readily sol in alcohol, ether. Soly in water: 0.24 g/100 ml at 16.5°. Melting point: mp 103° Therap-Cat: Analgesic; antipyretic; anti-inflammatory. Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Pyrazolones; Antipyretic. |
7楼2009-10-31 10:02:35
fdaedqm
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kidant(金币+1,VIP+0):谢谢提供帮助 10-31 10:24
kidant(金币+1,VIP+0):谢谢提供帮助 10-31 10:24
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Title: Tilidine CAS Registry Number: 20380-58-9 CAS Name: (1R,2S)-rel-2-(Dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylic acid ethyl ester Additional Names: ethyl 2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate; 3-trans-dimethylamino-4-phenyl-4-trans-carbethoxy-D1-cyclohexene Molecular Formula: C17H23NO2 Molecular Weight: 273.37 Percent Composition: C 74.69%, H 8.48%, N 5.12%, O 11.71% Literature References: Prepn: ZA 6606476; GB 1120186; G. Satzinger, US 3557127 (1967, 1968, 1971, all to Warner-Lambert). Synthesis of 6-C14 hydrochloride: K.-O. Vollmer, F. W. Koss, Arzneim.-Forsch. 20, 990 (1970). Pharmacology and toxicity data: M. Hermann et al., ibid. 977, 983. Metabolism: K.-O. Vollmer, H. Achenbach, ibid. 24, 1237 (1974). HPLC determn in pharmaceutics: D. Zivanov-Stakic et al., Farmaco 44, 759 (1989). Clinical trial in comparison with nefopam, q.v.: J. Abeloos et al., Acta Anaesthesiol. Belg. 34, 283 (1983); in combination with naloxone, q.v.: H. Van Cauwenberge et al., Int. J. Clin. Pharmacol. Res. 12, 1 (1992). Properties: bp0.01 95.5-96°. Boiling point: bp0.01 95.5-96° Derivative Type: Hydrochloride hemihydrate Manufacturers' Codes: Gö-1261C; W-5759A Trademarks: Lucayan (Corvi); Valoron (Gecke) Molecular Formula: C17H23NO2.HCl.½H2O Molecular Weight: 318.84 Percent Composition: C 64.04%, H 7.90%, N 4.39%, O 12.55%, Cl 11.12% Properties: Crystals, mp 125°. Easily sol in water. LD50 (7 day) in mice, rats (mg/kg): 437.0, 417.7 i.g.; 490.0, 400.0 s.c.; 52.0, 74.1 i.v. (Herrmann). Melting point: mp 125° Toxicity data: LD50 (7 day) in mice, rats (mg/kg): 437.0, 417.7 i.g.; 490.0, 400.0 s.c.; 52.0, 74.1 i.v. (Herrmann) Derivative Type: Hydrochloride CAS Registry Number: 27107-79-5 Properties: Crystals from ethyl acetate-methyl ethyl ketone, mp 159°. Melting point: mp 159° Derivative Type: cis-(±)-Form CAS Registry Number: 112244-09-4 Properties: bp0.01 97.5-98°. Boiling point: bp0.01 97.5-98° Derivative Type: cis-(±)-Hydrochloride Molecular Formula: C17H23NO2.HCl.1½H2O Molecular Weight: 318.84 Percent Composition: C 64.04%, H 7.90%, N 4.39%, O 12.55%, Cl 11.12% Properties: Crystals from ethyl acetate-methyl ethyl ketone, mp 84°. Melting point: mp 84° NOTE: This is a controlled substance (opiate): 21 CFR, 1308.11. Therap-Cat: Analgesic (narcotic). Keywords: Analgesic (Narcotic). |
8楼2009-10-31 10:04:23
fdaedqm
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9楼2009-10-31 10:04:54
10楼2009-11-02 16:27:13