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各位大叔大婶，兄弟姐妹们帮帮忙，本人急需以下物质合成文献： 盐酸氯米帕明（CAS号：17321-77-6），异丙安替比林（CAS号：479-92-5），盐酸替利定（CAS号：27107-79-5） 谢谢  |
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fdaedqm
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kidant(金币+1,VIP+0):谢谢提供帮助 10-31 10:24
kidant(金币+1,VIP+0):谢谢提供帮助 10-31 10:24
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Title: Tilidine CAS Registry Number: 20380-58-9 CAS Name: (1R,2S)-rel-2-(Dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylic acid ethyl ester Additional Names: ethyl 2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate; 3-trans-dimethylamino-4-phenyl-4-trans-carbethoxy-D1-cyclohexene Molecular Formula: C17H23NO2 Molecular Weight: 273.37 Percent Composition: C 74.69%, H 8.48%, N 5.12%, O 11.71% Literature References: Prepn: ZA 6606476; GB 1120186; G. Satzinger, US 3557127 (1967, 1968, 1971, all to Warner-Lambert). Synthesis of 6-C14 hydrochloride: K.-O. Vollmer, F. W. Koss, Arzneim.-Forsch. 20, 990 (1970). Pharmacology and toxicity data: M. Hermann et al., ibid. 977, 983. Metabolism: K.-O. Vollmer, H. Achenbach, ibid. 24, 1237 (1974). HPLC determn in pharmaceutics: D. Zivanov-Stakic et al., Farmaco 44, 759 (1989). Clinical trial in comparison with nefopam, q.v.: J. Abeloos et al., Acta Anaesthesiol. Belg. 34, 283 (1983); in combination with naloxone, q.v.: H. Van Cauwenberge et al., Int. J. Clin. Pharmacol. Res. 12, 1 (1992). Properties: bp0.01 95.5-96°. Boiling point: bp0.01 95.5-96° Derivative Type: Hydrochloride hemihydrate Manufacturers' Codes: Gö-1261C; W-5759A Trademarks: Lucayan (Corvi); Valoron (Gecke) Molecular Formula: C17H23NO2.HCl.½H2O Molecular Weight: 318.84 Percent Composition: C 64.04%, H 7.90%, N 4.39%, O 12.55%, Cl 11.12% Properties: Crystals, mp 125°. Easily sol in water. LD50 (7 day) in mice, rats (mg/kg): 437.0, 417.7 i.g.; 490.0, 400.0 s.c.; 52.0, 74.1 i.v. (Herrmann). Melting point: mp 125° Toxicity data: LD50 (7 day) in mice, rats (mg/kg): 437.0, 417.7 i.g.; 490.0, 400.0 s.c.; 52.0, 74.1 i.v. (Herrmann) Derivative Type: Hydrochloride CAS Registry Number: 27107-79-5 Properties: Crystals from ethyl acetate-methyl ethyl ketone, mp 159°. Melting point: mp 159° Derivative Type: cis-(±)-Form CAS Registry Number: 112244-09-4 Properties: bp0.01 97.5-98°. Boiling point: bp0.01 97.5-98° Derivative Type: cis-(±)-Hydrochloride Molecular Formula: C17H23NO2.HCl.1½H2O Molecular Weight: 318.84 Percent Composition: C 64.04%, H 7.90%, N 4.39%, O 12.55%, Cl 11.12% Properties: Crystals from ethyl acetate-methyl ethyl ketone, mp 84°. Melting point: mp 84° NOTE: This is a controlled substance (opiate): 21 CFR, 1308.11. Therap-Cat: Analgesic (narcotic). Keywords: Analgesic (Narcotic). |
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wjy82
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4楼2009-10-31 08:49:33