±±¾©Ê¯ÓÍ»¯¹¤Ñ§Ôº2026ÄêÑо¿ÉúÕÐÉú½ÓÊÕµ÷¼Á¹«¸æ
²é¿´: 156  |  »Ø¸´: 2
µ±Ç°Ö÷ÌâÒѾ­´æµµ¡£
µ±Ç°Ö»ÏÔʾÂú×ãÖ¸¶¨Ìõ¼þµÄ»ØÌû£¬µã»÷ÕâÀï²é¿´±¾»°ÌâµÄËùÓлØÌû

zhantian3529

Ìú¸Ëľ³æ (ÕýʽдÊÖ)

[½»Á÷] ¡¾×ªÌû¡¿Illuminating Anesthetic Targets

A photoreactive analog of a common inhaled anesthetic might shed light on the targets and binding sites of these promiscuous drugs. Volatility and low binding affinities plague efforts to pin down molecular targets for inhaled anesthetics such as isoflurane and sevoflurane, which are used every day in operating rooms worldwide. One way to get around those drawbacks is to synthesize versions of anesthetics with light-reactive moieties. However, current analogs have some disadvantages: They aren¡¯t exact mimics of known anesthetics, or they contain photoreactive groups that preferentially react with certain amino acids, potentially biasing the probes toward some binding sites and not others. Now, anesthesiologist Roderic G. Eckenhoff of the University of Pennsylvania School of Medicine and a multi-institution team have developed azi-isoflurane, a photoreactive mimic of isoflurane that has neither of those drawbacks (ACS Chem. Neurosci., DOI: 10.1021/cn900014m). Azi-isoflurane binds in known isoflurane binding pockets in two model proteins and is a more potent anesthetic than isoflurane in vivo. The team hopes to use azi-isoflurane to identify molecular targets underlying both the desirable and undesirable effects of isoflurane.


Chemical & Engineering News
ISSN 0009-2347
Copyright © 2009 American Chemical Society
»Ø¸´´ËÂ¥
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

ccq19

Òø³æ (СÓÐÃûÆø)

¡ï
Сľ³æ(½ð±Ò+0.2):ÇÀÁ˸öС°åµÊ£¬¸ø¸öºì°ü
¿´µ½´ó¶ÎÓ¢ÎÄÎÒ¾ÍÍ·ÌÛ
ÄãÒ»¼ú£¬ÎÒ¾ÍЦ
3Â¥2009-10-30 15:05:19
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
²é¿´È«²¿ 3 ¸ö»Ø´ð

wu3833145

ľ³æ (ÕýʽдÊÖ)

¡ï
Сľ³æ(½ð±Ò+0.5):¹§Ï²ÇÀɳ·¢£¬¸ø¸öºì°ü
ѧϰѧϰ£¬¸Ðл·ÖÏí
2Â¥2009-10-30 14:28:29
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] 070305¸ß·Ö×Ó»¯Ñ§ÓëÎïÀí 304·ÖÇóµ÷¼Á +5 c297914 2026-03-28 5/250 2026-03-28 20:37 by llc239
[¿¼ÑÐ] Çóµ÷¼ÁÒ»Ö¾Ô¸º£´ó£¬0703»¯Ñ§Ñ§Ë¶304·Ö£¬Óдó´´ÏîÄ¿£¬Ëļ¶Òѹý +7 ÐÒÔËÁ¨Á¨ 2026-03-22 11/550 2026-03-28 20:27 by ÌÆãå¶ù
[¿¼ÑÐ] 311£¨085601£©Çóµ÷¼Á +4 liziyeyeye 2026-03-28 4/200 2026-03-28 18:50 by 535743368
[¿¼ÑÐ] 283Çóµ÷¼Á +3 A child 2026-03-28 3/150 2026-03-28 15:41 by ms629
[¿¼ÑÐ] 299Çóµ÷¼Á +7 àÅàÅàÅàÅ2 2026-03-27 7/350 2026-03-28 13:09 by ÌÆãå¶ù
[¿¼ÑÐ] 085701»·¾³¹¤³Ì£¬267Çóµ÷¼Á +16 minht 2026-03-26 16/800 2026-03-28 12:16 by zllcz
[¿¼ÑÐ] °²»Õ´óѧר˶ÉúÎïÓëҽҩרҵ(086000)324·Ö£¬Ó¢ÓïÒѹýËÄÁù¼¶£¬Áù¼¶521£¬Çóµ÷¼Á +4 ÃÀζ¿ÉÀÖ¼¦³á 2026-03-26 4/200 2026-03-27 15:27 by ÐÇ¿ÕÐÇÔÂ
[¿¼ÑÐ] 312Çóµ÷¼Á +9 Éϰ¶°ÉZJY 2026-03-22 13/650 2026-03-27 11:24 by sanrepian
[ÂÛÎÄͶ¸å] Journal of Mechanical Science and Technology +3 Russ_ss 2026-03-25 5/250 2026-03-27 10:49 by ½С¹û»­´ó±ý
[¿¼ÑÐ] Ò»Ö¾Ô¸ÉÂʦ´óÉúÎïѧ071000£¬298·Ö£¬Çóµ÷¼Á +5 SYA£¡ 2026-03-23 5/250 2026-03-27 09:29 by ²»³Ôô~µÄ؈
[¿¼ÑÐ] Çóµ÷¼Á +6 ÁÖ֮Ϧ 2026-03-24 6/300 2026-03-27 08:38 by hypershenger
[¿¼ÑÐ] 321Çóµ÷¼Á +6 wasdssaa 2026-03-26 6/300 2026-03-26 20:57 by sanrepian
[¿¼ÑÐ] Ò»Ö¾Ô¸ºÓ¹¤´ó 081700 276Çóµ÷¼Á +4 µØÇòÈÆ×ÅÌ«Ñôת 2026-03-23 4/200 2026-03-26 14:27 by zzll406
[¿¼ÑÐ] »¯Ñ§µ÷¼ÁÒ»Ö¾Ô¸ÉϺ£½»Í¨´óѧ336·Ö-±¾¿ÆÉϺ£211 +4 СÓã°®Óлú 2026-03-25 4/200 2026-03-26 10:19 by aa331100
[¿¼ÑÐ] Ò»Ö¾Ô¸ÉϺ£½»´óÉúÎïÓëҽҩר˶324·Ö£¬Çóµ÷¼Á +6 jiajunX 2026-03-22 6/300 2026-03-25 23:05 by licg0208
[¿¼ÑÐ] 299Çóµ÷¼Á +4 15188958825 2026-03-25 4/200 2026-03-25 22:56 by 418490947
[¿¼ÑÐ] 302Çóµ÷¼Á +4 ½õÒÂÎÀÌÙ½· 2026-03-25 4/200 2026-03-25 16:29 by ¹¦·ò·è¿ñ
[¿¼ÑÐ] 293Çóµ÷¼Á +7 ¼ÓÒ»Ò»¾Å 2026-03-24 7/350 2026-03-25 12:02 by userper
[¿¼ÑÐ] 292Çóµ÷¼Á +4 ¶ì¶ì¶ì¶î¶î¶î¶î¶ 2026-03-24 4/200 2026-03-24 16:41 by peike
[¿¼ÑÐ] 336»¯¹¤µ÷¼Á +4 Íõ´ó̹1 2026-03-23 5/250 2026-03-23 18:32 by allen-yin
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û