| 查看: 152 | 回复: 2 | |||
| 当前主题已经存档。 | |||
zhantian3529铁杆木虫 (正式写手)
|
[交流]
【转帖】Illuminating Anesthetic Targets
|
||
|
A photoreactive analog of a common inhaled anesthetic might shed light on the targets and binding sites of these promiscuous drugs. Volatility and low binding affinities plague efforts to pin down molecular targets for inhaled anesthetics such as isoflurane and sevoflurane, which are used every day in operating rooms worldwide. One way to get around those drawbacks is to synthesize versions of anesthetics with light-reactive moieties. However, current analogs have some disadvantages: They aren’t exact mimics of known anesthetics, or they contain photoreactive groups that preferentially react with certain amino acids, potentially biasing the probes toward some binding sites and not others. Now, anesthesiologist Roderic G. Eckenhoff of the University of Pennsylvania School of Medicine and a multi-institution team have developed azi-isoflurane, a photoreactive mimic of isoflurane that has neither of those drawbacks (ACS Chem. Neurosci., DOI: 10.1021/cn900014m). Azi-isoflurane binds in known isoflurane binding pockets in two model proteins and is a more potent anesthetic than isoflurane in vivo. The team hopes to use azi-isoflurane to identify molecular targets underlying both the desirable and undesirable effects of isoflurane. Chemical & Engineering News ISSN 0009-2347 Copyright © 2009 American Chemical Society |
回复此楼» 猜你喜欢
2026申请考核博士自荐-蛋白质组学/AI/药物设计/AIDD/化学生物学
已经有1人回复
-
药理学、临床药学方向 调剂
已经有1人回复
-
药物学论文润色/翻译怎么收费?
已经有286人回复
-
锦州医科大学药用生物材料（专业代码1007Z1）招收调剂考生
已经有0人回复
-
锦州医科大学药用生物材料（专业代码1007Z1）招收调剂考生
已经有2人回复
-
中国医药行业发展现状：标准品推动药品检测水平提升
已经有1人回复
-
26申博自荐
已经有12人回复
-
标准品的纯度对于药品质量的影响有多大？
已经有0人回复
-
如何制备符合技术要求的药品标准品？
已经有0人回复
-
对照品在药品研发中的不可或缺性
已经有0人回复
2楼2009-10-30 14:28:29
3楼2009-10-30 15:05:19
