| 查看: 126 | 回复: 2 | |||
| 当前主题已经存档。 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
zhantian3529铁杆木虫 (正式写手)
|
[交流]
【转帖】Illuminating Anesthetic Targets
|
||
|
A photoreactive analog of a common inhaled anesthetic might shed light on the targets and binding sites of these promiscuous drugs. Volatility and low binding affinities plague efforts to pin down molecular targets for inhaled anesthetics such as isoflurane and sevoflurane, which are used every day in operating rooms worldwide. One way to get around those drawbacks is to synthesize versions of anesthetics with light-reactive moieties. However, current analogs have some disadvantages: They aren’t exact mimics of known anesthetics, or they contain photoreactive groups that preferentially react with certain amino acids, potentially biasing the probes toward some binding sites and not others. Now, anesthesiologist Roderic G. Eckenhoff of the University of Pennsylvania School of Medicine and a multi-institution team have developed azi-isoflurane, a photoreactive mimic of isoflurane that has neither of those drawbacks (ACS Chem. Neurosci., DOI: 10.1021/cn900014m). Azi-isoflurane binds in known isoflurane binding pockets in two model proteins and is a more potent anesthetic than isoflurane in vivo. The team hopes to use azi-isoflurane to identify molecular targets underlying both the desirable and undesirable effects of isoflurane. Chemical & Engineering News ISSN 0009-2347 Copyright © 2009 American Chemical Society |
回复此楼» 猜你喜欢
26有没有老师想收做定量药理的学生啊
已经有2人回复
-
关于口服溶液剂药品上市后稳定性研究
已经有2人回复
-
药理学论文润色/翻译怎么收费?
已经有53人回复
-
FDA核查 研发机构
已经有1人回复
-
国家高层次人才李兴淑教授课题组招收博士研究生
已经有39人回复
-
26考博申请 学or专
已经有15人回复
-
己酮可可碱过氧化杂质限度
已经有2人回复
-
求助Isoeugenol质量标准
已经有0人回复
-
Gliclazide
已经有0人回复
2楼2009-10-30 14:28:29