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从基因水平对高血压发病原因及机制的研究具有重要的理论和临床指导意义，但目前对该病相关基因的研究多局限在小群体、少数（单）基因的少数（单）位点，远缺乏系统性。鉴于此，本项目拟充分利用云南少数民族隔离人群的遗传资源优势，针对血压调控中最重要的系统之一肾素-血管紧张素-醛固酮系统（RAAS)，开展哈尼族、彝族及汉族的RAAS系统相关的全部9个基因（AGT、CYP11B2、ACE、ACE2、AT1、AT2、MAS1、REN、RenBP ）标签SNPs与原发性高血压发生的相关性研究，鉴定每个位点的基因型，构建9个基因的单倍型，确定云南隔离人群原发性高血压相关基因和位点相互作用的最佳有效组合模式，探讨不同遗传背景民族间血压调控基因的遗传学特征。力求系统、全面地揭示RAAS系统与高血压发病的相关性，阐明云南少数民族原发性高血压的发病机理，为其早期诊断和风险性评估提供理论依据。 翻译出完成后，金币一并给出。在线等，截止间：今天上午10点半 |
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jw227
木虫 (著名写手)
课题组长
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大雄好(金币+5,VIP+0):XIEXIE 9-10 09:06
大雄好(金币+1,VIP+0):谢谢 9-10 09:46
大雄好(金币+5,VIP+0):XIEXIE 9-10 09:06
大雄好(金币+1,VIP+0):谢谢 9-10 09:46
|
The research about mechanism of hypertension pathogenesis from the gene level is of important theoretical and clinical significance. but now, the related genes are limited in small groups, a small number of (single) gene in a small number of (single) sites, much lack of systemic. Thus, intending to take full advantage of genetic resources of isolated population in Yunnan's minorities and aiming at one of the most important system in blood pressure regulation, renin - angiotensin - aldosterone system (RAAS), [ Last edited by jw227 on 2009-9-8 at 10:57 ] |
2楼2009-09-08 10:30:30
jw227
木虫 (著名写手)
课题组长
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- 专业: 天然有机化学
3楼2009-09-08 10:34:22
jw227
木虫 (著名写手)
课题组长
- 翻译EPI: 2
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- 帖子: 1674
- 在线: 293.4小时
- 虫号: 236869
- 注册: 2006-04-03
- 性别: MM
- 专业: 天然有机化学
★ ★ ★ ★ ★ ★
大雄好(金币+5,VIP+0):谢谢 9-10 09:08
大雄好(金币+1,VIP+0):谢谢 9-10 09:46
大雄好(金币+5,VIP+0):谢谢 9-10 09:08
大雄好(金币+1,VIP+0):谢谢 9-10 09:46
|
The genotypes will be identified for every site. 9 haplotypes of genes will be established. The best combination mode of hypertension-related genes and its site in isolated population of Yunnan will be determined. The characteristic of blood pressure regulatory genes among nationalities with different genetic background will be explored. We will try our best to reveal the relevance of RAAS system and hypertension pathogenesis systematically and comprehensively ; clarify the mechanism of essential hypertension pathogenesis ; provide theoretical basis for early diagnosis and risk assessment. [ Last edited by jw227 on 2009-9-8 at 11:02 ] |
4楼2009-09-08 10:48:40
wyr2006
木虫 (著名写手)
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大雄好(金币+6,VIP+0):还是谢谢 9-10 09:47
大雄好(金币+6,VIP+0):还是谢谢 9-10 09:47
| To study the pathologic mechanism of hypertension on the genetic level has an important theoretical and clinical guiding significance. However, recent researches of hyptension related genes are restricted to small populations, less genes and loci, thus are lack of systematicness. In view of this, we are going to study the correlation between essential hypertension(EH) and tag SNPs in genes of the rennin-agiotensin-aldosterone system(RAAS), which plays a cardinal role in blood pressure regulation, by using the genetic resources of .... |
5楼2009-09-10 09:44:21
wyr2006
木虫 (著名写手)
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★ ★ ★ ★ ★
大雄好(金币+5,VIP+0): 9-10 09:47
大雄好(金币+5,VIP+0): 9-10 09:47
| The haplotypesand genotypes of each SNP will be determined as a result. So as to identify the optimal interactive mechanism of the EH associated genes and loci and explore the genetic characteristics of blood pressure control genes in different ethnic groups. We therefore will provide systematic and complete findings to reveal the association between the RAAS and the incidence of hypertension disease, and clarify the pathologic mechanism of... |
6楼2009-09-10 09:45:28
wyr2006
木虫 (著名写手)
- 应助: 1 (幼儿园)
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- 帖子: 1064
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- 注册: 2006-09-17
- 性别: MM
- 专业: 动物遗传学
7楼2009-09-10 09:45:50
