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262402xiaoyu

铜虫 (小有名气)

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专业: 污染控制化学

[交流] （急）15金币问寡核苷酸链的非特异吸附和空间位阻问题

各位GGJJ ，今天在看一篇文献时（《Rigid carbon composites: a new transducing material for label-free electrochemical genosensing》）发现其中一段话“As can be seen from Fig. 4(A), with an increment of the IS200 target concentration, the guanine (a) and the adenine (b) signals increased up to 60 lg/ml. After this concentration, a slight reduction of the electrochemical signal was observed. This decrease in the signal, related
to higher quantities of DNA, can be explained either by steric hindrance or by non-specific self-association. Both effects compete with ssDNA adsorption on the transducer, thus decreasing the signal.”
请问一下This decrease in the signal, related to higher quantities of DNA, can be explained either by steric hindrance or by non-specific self-association. 中的steric hindrance 和non-specific self-association是什么意思啊 ? non-specific self-association的机理是什么呢？帮帮忙给予解答啦，最好能帮忙找点参考文献，谢谢大家