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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
nandehutu9327: 金币+10, ★★★★★最佳答案 2017-10-24 11:38:28
心静_依然: LS-EPI+1, 感谢应助 2017-10-24 15:40:20
Steady-state optimization of biochemical systems by bi-level programming
作者:Xu, GX (Xu, Gongxian)[ 1 ] ; Li, Y (Li, Yang)[ 1 ]
COMPUTERS & CHEMICAL ENGINEERING
卷: 106
页: 286-296
DOI: 10.1016/j.compchemeng.2017.06.019
出版年: NOV 2 2017
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摘要
A new method is proposed for the steady-state optimization of biochemical systems described by Generalized Mass Action (GMA) models. In this method, a bi-level programming with a two-layer nested structure is established. In this bi-level problem, the upper-level objective is to maximize a flux or a metabolite concentration, and the lower-level objective is to minimize the total sum of metabolite concentrations of biochemical systems. The biological significance of the presented bi-level programming problem is to maximize the production rate or concentration of the desired product under a minimal metabolic cost to the biochemical system. To efficiently solve the above NP-hard, non-convex and nonlinear bi-level programming problem, we reformulate it into a single-level optimization problem by using appropriate transformation strategies. The proposed framework is applied to four case studies and has shown the tractability and effectiveness of the method. A comparison of our proposed method and other methods is also given. (C) 2017 Elsevier Ltd. All rights reserved.
关键词
作者关键词:Optimization; Bi-level programming; Algorithm; Generalized mass action; Biochemical systems
KeyWords Plus:METABOLIC CONTROL-THEORY; POWER-LAW APPROXIMATION; SACCHAROMYCES-CEREVISIAE; FERMENTATION PATHWAY; BILEVEL OPTIMIZATION; GLOBAL OPTIMIZATION; MODEL; ALGORITHM; NETWORKS; MAXIMIZATION
作者信息
通讯作者地址: Xu, GX (通讯作者)
Bohai Univ, Dept Math, Jinzhou 121013, Peoples R China.
地址:
[ 1 ] Bohai Univ, Dept Math, Jinzhou 121013, Peoples R China
电子邮件地址:gxxu@bhu.edu.cn
基金资助致谢
基金资助机构
授权号
National Natural Science Foundation of China
11101051
11371071
Liaoning Provincial Natural Science Foundation of China
2015020038
Program for Liaoning Excellent Talents in University
LJQ2013115
Program for Liaoning Innovative Research Team in University
LT2014024
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出版商
PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
类别 / 分类
研究方向:Computer Science; Engineering
Web of Science 类别:Computer Science, Interdisciplinary Applications; Engineering, Chemical
文献信息
文献类型:Article
语种:English
入藏号: WOS:000412192800021
ISSN: 0098-1354
eISSN: 1873-4375
其他信息
IDS 号: FI7QR
Web of Science 核心合集中的 "引用的参考文献": 58
Web of Science 核心合集中的 "被引频次": 0 |
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