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nandehutu9327至尊木虫 (职业作家)
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[求助]
求帮助查询论文是否已被SCI收录，谢谢！
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求帮助查询论文是否已被SCI收录，谢谢！ Steady-state Optimization of Biochemical Systems by Bi-level Programming |
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baiyuefei
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nandehutu9327: 金币+10, ★★★★★最佳答案 2017-10-24 11:38:28
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感谢参与，应助指数 +1
nandehutu9327: 金币+10, ★★★★★最佳答案 2017-10-24 11:38:28
心静_依然: LS-EPI+1, 感谢应助 2017-10-24 15:40:20
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Steady-state optimization of biochemical systems by bi-level programming 作者:Xu, GX (Xu, Gongxian)[ 1 ] ; Li, Y (Li, Yang)[ 1 ] COMPUTERS & CHEMICAL ENGINEERING 卷: 106 页: 286-296 DOI: 10.1016/j.compchemeng.2017.06.019 出版年: NOV 2 2017 查看期刊影响 摘要 A new method is proposed for the steady-state optimization of biochemical systems described by Generalized Mass Action (GMA) models. In this method, a bi-level programming with a two-layer nested structure is established. In this bi-level problem, the upper-level objective is to maximize a flux or a metabolite concentration, and the lower-level objective is to minimize the total sum of metabolite concentrations of biochemical systems. The biological significance of the presented bi-level programming problem is to maximize the production rate or concentration of the desired product under a minimal metabolic cost to the biochemical system. To efficiently solve the above NP-hard, non-convex and nonlinear bi-level programming problem, we reformulate it into a single-level optimization problem by using appropriate transformation strategies. The proposed framework is applied to four case studies and has shown the tractability and effectiveness of the method. A comparison of our proposed method and other methods is also given. (C) 2017 Elsevier Ltd. All rights reserved. 关键词 作者关键词:Optimization; Bi-level programming; Algorithm; Generalized mass action; Biochemical systems KeyWords Plus:METABOLIC CONTROL-THEORY; POWER-LAW APPROXIMATION; SACCHAROMYCES-CEREVISIAE; FERMENTATION PATHWAY; BILEVEL OPTIMIZATION; GLOBAL OPTIMIZATION; MODEL; ALGORITHM; NETWORKS; MAXIMIZATION 作者信息 通讯作者地址: Xu, GX (通讯作者) Bohai Univ, Dept Math, Jinzhou 121013, Peoples R China. 地址: [ 1 ] Bohai Univ, Dept Math, Jinzhou 121013, Peoples R China 电子邮件地址:gxxu@bhu.edu.cn 基金资助致谢 基金资助机构 授权号 National Natural Science Foundation of China 11101051 11371071 Liaoning Provincial Natural Science Foundation of China 2015020038 Program for Liaoning Excellent Talents in University LJQ2013115 Program for Liaoning Innovative Research Team in University LT2014024 查看基金资助信息 出版商 PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 类别 / 分类 研究方向:Computer Science; Engineering Web of Science 类别:Computer Science, Interdisciplinary Applications; Engineering, Chemical 文献信息 文献类型:Article 语种:English 入藏号: WOS:000412192800021 ISSN: 0098-1354 eISSN: 1873-4375 其他信息 IDS 号: FI7QR Web of Science 核心合集中的 "引用的参考文献": 58 Web of Science 核心合集中的 "被引频次": 0 |
2楼2017-10-24 10:39:01