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kele1982

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[交流] 【求助】QSAR模型中交叉验证系数（q2）怎么获得？已有2人参与

请问我用逐步回归分析方法得到一个QSAR模型，但是结果里面没有交叉验证系数q2（英文叫: leave-one-out），请问怎么计算得到啊？谢谢

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Consensus QSAR models: Do the benefits outweigh the complexity?

Author(s): Hewitt M (Hewitt, Mark), Cronin MTD (Cronin, Mark T. D.), Madden JC (Madden, Judith C.), Rowe PH (Rowe, Philip H.), Johnson C (Johnson, Clara), Obi A (Obi, Anrdrea), Enoch SJ (Enoch, Steven J.)

Source: JOURNAL OF CHEMICAL INFORMATION AND MODELING Volume: 47 Issue: 4 Pages: 1460-1468 DOI: 10.1021/ci700016d Published: JUL-AUG 2007

Abstract: This study has assessed the use of consensus regression, as compared to single multiple linear regression, models for the development of quantitative structure-activity relationships (QSARs). To provide a comparison, four data sets of varying size and complexity were analyzed: silastic membrane flux, toxicity of phenols to Tetrahymena pyriformis, acute toxicity to the fathead minnow and flash point. For each data set, a genetic algorithm was used to develop a model population and the performance of consensus models was compared to that of the best single model. Two consensus models were developed, one using the top 10 models, and the other using a subset of models chosen to provide maximal coverage of model space. The results highlight the ability of the genetic algorithm to develop predictive models from a large descriptor pool. However, the consensus models were shown to offer no significant improvements over single regression models, which are as statistically robust as the equivalent consensus models. Consensus models developed from a selection of the best QSARs were shown not to be superior to a selection of diverse in "model space" QSARs. For the data sets analyzed in this study, and in light of the Organization for Economic Cooperation and Development principles for the validation of QSARs, the increase in model complexity when using consensus models does not seem warranted given the minimal improvement in model statistics.