|
|
【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
vwkiller: 金币+20, ★★★★★最佳答案 2016-12-05 14:53:23
心静_依然: LS-EPI+1, 感谢应助 2016-12-05 18:24:09
Validated UPLC-MS/MS Method for the Determination of Sunitinib in Rat Plasma
作者:Zhang, Y (Zhang, Yu)[ 1 ] ; Yuan, RR (Yuan, Rong-rong)[ 1 ] ; Zheng, XK (Zheng, Xiao-kang)[ 2 ] ; Hua, CL (Hua, Chang-lin)[ 2 ] ; Wang, YQ (Wang, Ya-qiang)[ 1 ]
LATIN AMERICAN JOURNAL OF PHARMACY
卷: 35
期: 6
页: 1304-1308
出版年: 2016
查看期刊信息
摘要
In this study, a simple, rapid and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method is described for determination of sunitinib in rat plasma samples using diazepam as the internal standard (IS) from pharmacokinetic assays. Sample preparation was accomplished through a simple protein precipitation with acetonitrile, and chromatographic separation was performed on an Acquity BEH C18 column (2.1 mm x 50 mm, 1.7 mu m) with gradient profile at a flow of 0.40 ml/min. The linearity of this method was found to be within the concentration range of 0.2-400 ng/mL for sunitinib in rat plasma. Only 3.0 min was needed for an analytical run. The method was applied to a pharmacokinetic study of sunitinib in rats.
关键词
作者关键词:sunitinib; UPLC-MS/MS; rat plasma; pharmacokinetics
KeyWords Plus:TANDEM MASS-SPECTROMETRY; N-DESETHYL SUNITINIB; RENAL-CELL CARCINOMA; ACTIVE METABOLITE; TYROSINE KINASE; MOUSE PLASMA; QUANTIFICATION; INHIBITOR; QUANTITATION; SORAFENIB
作者信息
通讯作者地址: Wang, YQ (通讯作者)
[显示增强组织信息的名称] Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China.
地址:
[显示增强组织信息的名称] [ 1 ] Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China
[显示增强组织信息的名称] [ 2 ] Henan Univ Sci & Technol, Coll Med, Luoyang 471003, Peoples R China
电子邮件地址:kgwangyq@163.com
出版商
COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES, DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
类别 / 分类
研究方向 harmacology & Pharmacy
Web of Science 类别harmacology & Pharmacy
文献信息
文献类型:Article
语种:English
入藏号: WOS:000384517000005
ISSN: 0326-2383
期刊信息
Impact Factor (影响因子): Journal Citation Reports®
其他信息
IDS 号: DX6TW
Web of Science 核心合集中的 "引用的参考文献": 21
Web of Science 核心合集中的 "被引频次": 0 |
|
回复此楼