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Validated UPLC-MS/MS Method for the Determination of Sunitinib in Rat Plasma ÔÓÖ¾ÉçÊÇLatin American Journal of Pharmacy ·Ç³£¸Ðл @°¢Å¬ ·¢×ÔСľ³æAndroid¿Í»§¶Ë |
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vwkiller: ½ð±Ò+20, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2016-12-05 14:53:23
Ðľ²_ÒÀÈ»: LS-EPI+1, ¸ÐлӦÖú 2016-12-05 18:24:09
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Validated UPLC-MS/MS Method for the Determination of Sunitinib in Rat Plasma ×÷Õß:Zhang, Y (Zhang, Yu)[ 1 ] ; Yuan, RR (Yuan, Rong-rong)[ 1 ] ; Zheng, XK (Zheng, Xiao-kang)[ 2 ] ; Hua, CL (Hua, Chang-lin)[ 2 ] ; Wang, YQ (Wang, Ya-qiang)[ 1 ] LATIN AMERICAN JOURNAL OF PHARMACY ¾í: 35 ÆÚ: 6 Ò³: 1304-1308 ³ö°æÄê: 2016 ²é¿´ÆÚ¿¯ÐÅÏ¢ ÕªÒª In this study, a simple, rapid and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method is described for determination of sunitinib in rat plasma samples using diazepam as the internal standard (IS) from pharmacokinetic assays. Sample preparation was accomplished through a simple protein precipitation with acetonitrile, and chromatographic separation was performed on an Acquity BEH C18 column (2.1 mm x 50 mm, 1.7 mu m) with gradient profile at a flow of 0.40 ml/min. The linearity of this method was found to be within the concentration range of 0.2-400 ng/mL for sunitinib in rat plasma. Only 3.0 min was needed for an analytical run. The method was applied to a pharmacokinetic study of sunitinib in rats. ¹Ø¼ü´Ê ×÷Õ߹ؼü´Ê:sunitinib; UPLC-MS/MS; rat plasma; pharmacokinetics KeyWords Plus:TANDEM MASS-SPECTROMETRY; N-DESETHYL SUNITINIB; RENAL-CELL CARCINOMA; ACTIVE METABOLITE; TYROSINE KINASE; MOUSE PLASMA; QUANTIFICATION; INHIBITOR; QUANTITATION; SORAFENIB ×÷ÕßÐÅÏ¢ ͨѶ×÷ÕßµØÖ·: Wang, YQ (ͨѶ×÷Õß) [ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ] Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China. µØÖ·: [ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ] [ 1 ] Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China [ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ] [ 2 ] Henan Univ Sci & Technol, Coll Med, Luoyang 471003, Peoples R China µç×ÓÓʼþµØÖ·:kgwangyq@163.com ³ö°æÉÌ COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES, DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA Àà±ð / ·ÖÀà Ñо¿·½Ïò harmacology & PharmacyWeb of Science Àà±ð harmacology & PharmacyÎÄÏ×ÐÅÏ¢ ÎÄÏ×ÀàÐÍ:Article ÓïÖÖ:English Èë²ØºÅ: WOS:000384517000005 ISSN: 0326-2383 ÆÚ¿¯ÐÅÏ¢ Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports® ÆäËûÐÅÏ¢ IDS ºÅ: DX6TW Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 21 Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0 |
2Â¥2016-12-05 12:13:38
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3Â¥2016-12-05 12:13:56
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