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Validated UPLC-MS/MS Method for the Determination of Sunitinib in Rat Plasma

ÔÓÖ¾ÉçÊÇLatin American Journal of Pharmacy

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vwkiller: ½ð±Ò+20, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2016-12-05 14:53:23
Ðľ²_ÒÀÈ»: LS-EPI+1, ¸ÐлӦÖú 2016-12-05 18:24:09
Validated UPLC-MS/MS Method for the Determination of Sunitinib in Rat Plasma

×÷Õß:Zhang, Y (Zhang, Yu)[ 1 ] ; Yuan, RR (Yuan, Rong-rong)[ 1 ] ; Zheng, XK (Zheng, Xiao-kang)[ 2 ] ; Hua, CL (Hua, Chang-lin)[ 2 ] ; Wang, YQ (Wang, Ya-qiang)[ 1 ]

LATIN AMERICAN JOURNAL OF PHARMACY

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Ò³: 1304-1308

³ö°æÄê: 2016

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In this study, a simple, rapid and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method is described for determination of sunitinib in rat plasma samples using diazepam as the internal standard (IS) from pharmacokinetic assays. Sample preparation was accomplished through a simple protein precipitation with acetonitrile, and chromatographic separation was performed on an Acquity BEH C18 column (2.1 mm x 50 mm, 1.7 mu m) with gradient profile at a flow of 0.40 ml/min. The linearity of this method was found to be within the concentration range of 0.2-400 ng/mL for sunitinib in rat plasma. Only 3.0 min was needed for an analytical run. The method was applied to a pharmacokinetic study of sunitinib in rats.
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×÷Õ߹ؼü´Ê:sunitinib; UPLC-MS/MS; rat plasma; pharmacokinetics

KeyWords Plus:TANDEM MASS-SPECTROMETRY; N-DESETHYL SUNITINIB; RENAL-CELL CARCINOMA; ACTIVE METABOLITE; TYROSINE KINASE; MOUSE PLASMA; QUANTIFICATION; INHIBITOR; QUANTITATION; SORAFENIB
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ͨѶ×÷ÕßµØÖ·: Wang, YQ (ͨѶ×÷Õß)
[ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ]         Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China.

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[ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ]         [ 1 ] Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China
[ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ]         [ 2 ] Henan Univ Sci & Technol, Coll Med, Luoyang 471003, Peoples R China

µç×ÓÓʼþµØÖ·:kgwangyq@163.com
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COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES, DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
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Ñо¿·½Ïòharmacology & Pharmacy

Web of Science Àà±ðharmacology & Pharmacy
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ÎÄÏ×ÀàÐÍ:Article

ÓïÖÖ:English

Èë²ØºÅ: WOS:000384517000005

ISSN: 0326-2383
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    Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports®

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Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 21

Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0
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vwkiller

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Èë²ØºÅ: WOS:000384517000005

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