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| ¹òÇóSilymarin versus Silibinin: Differential Antioxidant and Neuroprotective Effects against H2O2-induced Oxidative Stress in PC12 Cells.ÕâÆªÎÄÕµļìË÷ºÅ£¡ |
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609718476: ½ð±Ò+12, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2016-10-28 11:30:28
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Silymarin versus Silibinin: Differential Antioxidant and Neuroprotective Effects against H2O2-induced Oxidative Stress in PC12 Cells ×÷Õß:Jiang, HH (Jiang, Hui-Hui)[ 1 ] ; Yan, FS (Yan, Fa-Shun)[ 1 ] ; Shen, L (Shen, Liang)[ 1 ] ; Ji, HF (Ji, Hong-Fang)[ 1 ] NATURAL PRODUCT COMMUNICATIONS ¾í: 11 ÆÚ: 5 Ò³: 633-636 ³ö°æÄê: MAY 2016 ²é¿´ÆÚ¿¯ÐÅÏ¢ ÕªÒª The present study assessed comparatively the antioxidant activities of silymarin and its major active component silibinin and their neuroprotective effects against hydrogen peroxide (H2O2)-induced oxidative stress in rat pheochromocytoma PC12 cells. It was found that despite newly prepared silymarin and silibinin solution possessing comparable superoxide anion (O-2(center dot-))-scavenging activities, with time the activity of silymarin lowered slightly, but that of silibinin decreased dramatically. Both silymarin and silibinin suppressed H2O2 -induced oxidative stress and apoptosis, and the neuroprotective effect of silymarin was overall relatively stronger than that of silibinin. The findings provided clues for future studies on therapeutic potentials of the whole silymarin or purified silibinin for neurodegenerative diseases. ¹Ø¼ü´Ê ×÷Õ߹ؼü´Ê:Silymarin; Silibinin; Neurodegenerative diseases; Neuroprotective effects; PC12 cells KeyWords Plus:THISTLE SILYBUM-MARIANUM; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; MILK THISTLE; NEURODEGENERATIVE DISEASES; MECHANISMS; MODEL; PREVALENCE; DISORDERS; APOPTOSIS ×÷ÕßÐÅÏ¢ ͨѶ×÷ÕßµØÖ·: Shen, L; Ji, HF (ͨѶ×÷Õß) ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ Shandong Univ Technol, Sch Life Sci, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China. µØÖ·: ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ [ 1 ] Shandong Univ Technol, Sch Life Sci, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China µç×ÓÓʼþµØÖ·:shen@sdut.edu.cn; jhf@sdut.edu.cn »ù½ð×ÊÖúÖÂл »ù½ð×ÊÖú»ú¹¹ ÊÚȨºÅ Shandong Provincial Science Foundation for Distinguished Young Scholars JQ201508 Shandong Provincial Science Foundation ZR2015JL010 ZR2014CL008 ²é¿´»ù½ð×ÊÖúÐÅÏ¢ ³ö°æÉÌ NATURAL PRODUCTS INC, 7963 ANDERSON PARK LN, WESTERVILLE, OH 43081 USA Àà±ð / ·ÖÀà Ñо¿·½Ïò harmacology & Pharmacy; Food Science & TechnologyWeb of Science Àà±ð:Chemistry, Medicinal; Food Science & Technology ÎÄÏ×ÐÅÏ¢ ÎÄÏ×ÀàÐÍ:Article ÓïÖÖ:English Èë²ØºÅ: WOS:000375633500020 PubMed ID: 27319137 ISSN: 1934-578X eISSN: 1555-9475 ÆÚ¿¯ÐÅÏ¢ Ŀ¼£º Current Contents Connect® Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports® ÆäËûÐÅÏ¢ IDS ºÅ: DL4UO Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 32 Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0 |
3Â¥2016-10-28 11:14:58









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harmacology & Pharmacy; Food Science & Technology
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