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609718476铜虫 (小有名气)
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wangxiaomail
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4楼2016-10-28 11:18:00
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2楼2016-10-28 11:00:11
wangxiaomail
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609718476: 金币+12, ★★★★★最佳答案 2016-10-28 11:30:28
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609718476: 金币+12, ★★★★★最佳答案 2016-10-28 11:30:28
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Silymarin versus Silibinin: Differential Antioxidant and Neuroprotective Effects against H2O2-induced Oxidative Stress in PC12 Cells 作者:Jiang, HH (Jiang, Hui-Hui)[ 1 ] ; Yan, FS (Yan, Fa-Shun)[ 1 ] ; Shen, L (Shen, Liang)[ 1 ] ; Ji, HF (Ji, Hong-Fang)[ 1 ] NATURAL PRODUCT COMMUNICATIONS 卷: 11 期: 5 页: 633-636 出版年: MAY 2016 查看期刊信息 摘要 The present study assessed comparatively the antioxidant activities of silymarin and its major active component silibinin and their neuroprotective effects against hydrogen peroxide (H2O2)-induced oxidative stress in rat pheochromocytoma PC12 cells. It was found that despite newly prepared silymarin and silibinin solution possessing comparable superoxide anion (O-2(center dot-))-scavenging activities, with time the activity of silymarin lowered slightly, but that of silibinin decreased dramatically. Both silymarin and silibinin suppressed H2O2 -induced oxidative stress and apoptosis, and the neuroprotective effect of silymarin was overall relatively stronger than that of silibinin. The findings provided clues for future studies on therapeutic potentials of the whole silymarin or purified silibinin for neurodegenerative diseases. 关键词 作者关键词:Silymarin; Silibinin; Neurodegenerative diseases; Neuroprotective effects; PC12 cells KeyWords Plus:THISTLE SILYBUM-MARIANUM; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; MILK THISTLE; NEURODEGENERATIVE DISEASES; MECHANISMS; MODEL; PREVALENCE; DISORDERS; APOPTOSIS 作者信息 通讯作者地址: Shen, L; Ji, HF (通讯作者) 显示增强组织信息的名称 Shandong Univ Technol, Sch Life Sci, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China. 地址: 显示增强组织信息的名称 [ 1 ] Shandong Univ Technol, Sch Life Sci, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China 电子邮件地址:shen@sdut.edu.cn; jhf@sdut.edu.cn 基金资助致谢 基金资助机构 授权号 Shandong Provincial Science Foundation for Distinguished Young Scholars JQ201508 Shandong Provincial Science Foundation ZR2015JL010 ZR2014CL008 查看基金资助信息 出版商 NATURAL PRODUCTS INC, 7963 ANDERSON PARK LN, WESTERVILLE, OH 43081 USA 类别 / 分类 研究方向  harmacology & Pharmacy; Food Science & TechnologyWeb of Science 类别:Chemistry, Medicinal; Food Science & Technology 文献信息 文献类型:Article 语种:English 入藏号: WOS:000375633500020 PubMed ID: 27319137 ISSN: 1934-578X eISSN: 1555-9475 期刊信息 目录： Current Contents Connect® Impact Factor (影响因子): Journal Citation Reports® 其他信息 IDS 号: DL4UO Web of Science 核心合集中的 "引用的参考文献": 32 Web of Science 核心合集中的 "被引频次": 0 |
3楼2016-10-28 11:14:58
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