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热传导微量热仪在药物稳定性的研究方法中实现评估微量热的响应效果
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In preformulation and formulation work on pharmaceutical preparations preliminary testing of stability often requires high temperatures and therefore suffers from the uncertainty of extrapolation to room temperatures. (These methods of calculation of stability are only valid if the mechanism of reaction remains unchanged over the temperature range studied). Since with isothermal heat conduction microcalorimetry the intensity of heat flow (dq/dt) is related to the concentration of sample, enthalpy of reaction and the rate constant, the rate of degradation of a sample can sometimes be calculated at close to normal storage conditions. The objective of this study was to determine the rate constants and to evaluate the precision and accuracy of microcalorimetric data for the hydrolysis of acetylsalicylic acid (ASA) at different temperatures and pH values. Furthermore, the microcalorimetric response was evaluated by two additional methods. |
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