| 查看: 279 | 回复: 0 | |||
[交流]
热传导微量热仪在药物稳定性的研究方法中实现评估微量热的响应效果
|
| In preformulation and formulation work on pharmaceutical preparations preliminary testing of stability often requires high temperatures and therefore suffers from the uncertainty of extrapolation to room temperatures. (These methods of calculation of stability are only valid if the mechanism of reaction remains unchanged over the temperature range studied). Since with isothermal heat conduction microcalorimetry the intensity of heat flow (dq/dt) is related to the concentration of sample, enthalpy of reaction and the rate constant, the rate of degradation of a sample can sometimes be calculated at close to normal storage conditions. The objective of this study was to determine the rate constants and to evaluate the precision and accuracy of microcalorimetric data for the hydrolysis of acetylsalicylic acid (ASA) at different temperatures and pH values. Furthermore, the microcalorimetric response was evaluated by two additional methods. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 热传导微量热仪在药物稳定性的研究方法中实现评估微量热的响应效果.pdf
2016-06-30 16:58:27, 597.67 K
» 猜你喜欢
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有3人回复
-
售SCI一区文章，我:8.O.55.1.O.54,科目齐全,可伽急
已经有3人回复
-
我就是申请一个面上项目而已，这评审意见是按照杰青的条件评的吧？
已经有3人回复
-
有多少人是今天查系统知道结果的？
已经有18人回复
-
国自然评审意见
已经有15人回复
-
为什么资助数各大高校都创新高，自己申请怎么就这么难
已经有13人回复
-
国自然面上复盘~欢迎讨论
已经有14人回复
-
系统查不到
已经有11人回复
-
有没有仍没收到信息的
已经有3人回复
-
导师吐槽：我怎么摊上了这么个极品研究生！
已经有8人回复
10