| 查看: 277 | 回复: 0 | |||
[交流]
热传导微量热仪在药物稳定性的研究方法中实现评估微量热的响应效果
|
| In preformulation and formulation work on pharmaceutical preparations preliminary testing of stability often requires high temperatures and therefore suffers from the uncertainty of extrapolation to room temperatures. (These methods of calculation of stability are only valid if the mechanism of reaction remains unchanged over the temperature range studied). Since with isothermal heat conduction microcalorimetry the intensity of heat flow (dq/dt) is related to the concentration of sample, enthalpy of reaction and the rate constant, the rate of degradation of a sample can sometimes be calculated at close to normal storage conditions. The objective of this study was to determine the rate constants and to evaluate the precision and accuracy of microcalorimetric data for the hydrolysis of acetylsalicylic acid (ASA) at different temperatures and pH values. Furthermore, the microcalorimetric response was evaluated by two additional methods. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 热传导微量热仪在药物稳定性的研究方法中实现评估微量热的响应效果.pdf
2016-06-30 16:58:27, 597.67 K
» 猜你喜欢
求各位大神看下
已经有23人回复
-
面上再次挂了，太难了，躺也躺不了，倦也卷不过，小学校之殇！
已经有30人回复
-
2027年申博
已经有4人回复
-
好消息？这个有何含义？？？
已经有10人回复
-
咨询面上基金
已经有4人回复
-
8月时间戳变的，举个手。玩一下，释放压力
已经有10人回复
-
【2027博士申请】纳米药物递送方向
已经有4人回复
-
UV压敏胶开发
已经有7人回复
-
有没有H口的？有收到消息的吗？
已经有3人回复
-
十年后又回来了，论文投稿求助
已经有3人回复