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Intriguingly, the innovation of a fragment-based drug design (FBDD) approach has enabled rapid and efficient progress in drug discovery. In this critical review, we focus on the construction of fragment libraries and the advantages and disadvantages of various fragment-based screening (FBS) for constructing such libraries. We also highlight the deconstruction–reconstruction strategy by utilizing privileged fragments of reported ligands. 发自小木虫Android客户端 |
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彩虹糖的秘密(空位代发): 金币+10, 感谢应助 2016-02-16 14:41:54
彩虹糖的秘密(空位代发): 金币+10, 感谢应助 2016-02-16 14:41:54
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Intriguingly, the innovation of a fragment-based drug design (FBDD) approach has enabled rapid and efficient progress in drug discovery. In this critical review, we focus on the construction of fragment libraries and the advantages and disadvantages of various fragment-based screening (FBS) for constructing such libraries. We also highlight the–reconstruction strategy by utilizing privileged fragments of reported ligands. 有趣的是，新发明的一种基于片断的药物设计方法使药物的发现过程变得快速和有效。在本评论性综述中，我们专注于片断文库的建构以及各种用于建造这些文库的基于片断的筛选方法的利弊。我们也强调通过利用已见报的（配位体的）有授权的片断来解构和重建文库的策略方法。 |
2楼2016-01-10 22:32:38
2551088398
金虫 (小有名气)
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3楼2016-01-12 08:26:12
4楼2016-01-12 11:17:27
2551088398
金虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 335.1
- 帖子: 157
- 在线: 50.8小时
- 虫号: 3645212
- 注册: 2015-01-14
- 性别: GG
- 专业: 胶体与界面化学
5楼2016-01-12 12:58:13