| 查看: 1337 | 回复: 26 | |||
| 【奖励】 本帖被评价26次，作者1949stone增加金币 20.6 个 | |||
[资源]
Glycosylation
|
|||
|
Glycosylation is a post-translational modification of proteins occurring through the covalent attachment of glycans to the polypeptide chains during their maturation events. Affecting more then 70% of the eukariotic proteins, glycosylation is one of the most fascinating cellular processes in terms of its consequences upon the protein function. Normally exposed at the protein surface, glycans may protect proteins from denaturation or proteases attack securing their functional integrity in tissues or may act as targets for various biological recognition events. In the absence of glycosylation, some therapeutical recombinant proteins were reported to lose specificity of function. A lot of effort has been made to discover the glycosylation signature in the DNA sequence, to uncover the structural diversity of glycans in various organisms and to understand the way this post-translational process may determine the fate of a protein. This book, outlining the concepts of glycobiology, is a suite of reviews and articles written by a team of acknowledged researchers and covers some of the key topics in the field. The fundamentals of the N-glycosylation process occurring within the endoplasmic reticulum, together with the role of bioinformatics in understanding the process, with emphasis on the definition and role of the glycosylation sequon for glycoprotein function are presented. The reader is further introduced to the NMR spectroscopy described here as a tool for understanding glycobiology at a molecular level, but also for medical application related to glycosylated biomarkers in disease. An important chapter of the structural biology section deals with the most advanced methods developed to produce highly homogenous glycoforms for crystalisation studies using various expression systems. The increasing interest in the cell biology of glycosylation is reflected in an interesting approach regarding a role of glycosylation in the intracellular transport of amyloids and the dynamics of amyloid formation. In the same section, we address the role of glycosylation in modulating the functions of glycoproteins, in particular receptor signaling and the sorting of proteoglycans in specialised cells. Considering the growing knowledge in the multiple glycoforms discovered recently in both eukariotes and prokariotes, several chapters dealing with the diversity of glycosylation, as well as new functions of some toxins as glycosylating enzymes are also included in this book. A biomedical application of acquiring in depth knowledge of glycosylation principles is the formulation of pharmaceutically active proteins. The glycosylation of recombinant proteins and the generation of sialylated monoclonal antibodies with specific therapeutic goals is presented in a dedicated section. Covering a wide range of theoretical and practical issues in the field of glycobiology, the Glycosylation book will be of immediate value for students, academics and researchers involved in drug glycoengineering and biomedical research. I would like to acknowledge and thank all authors for their contribution in writing the book and Mr. Vedran Greblo and his team for their technical guidance. Sefana Petrescu, Ph.D Director of Institute of Biochemistry, Romanian Academy, Bucharest, Romania |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : Glycosylation.pdf
2015-12-19 23:29:18, 20.39 M
» 收录本帖的淘帖专辑推荐
 待下载 |
» 猜你喜欢
🔥速览｜AACR 2026 mRNA肿瘤疫苗临床捷报
已经有0人回复
-
深圳理工大学和东南大学联合培养博士招生（2026年9月入学）
已经有11人回复
-
药理学论文润色/翻译怎么收费?
已经有90人回复
-
211高校2026年入学博士名额
已经有14人回复
-
211高校2026年入学博士名额
已经有15人回复
-
211高校2026年入学博士名额
已经有16人回复
-
随访时间怎么确定
已经有0人回复
-
海勃原辅料助力银屑病一线外用制剂开发
已经有0人回复
-
求大佬收留
已经有0人回复
-
二乙烯基砜的合成路径
已经有1人回复
简单回复
wang3692楼
2015-12-20 13:29
回复
五星好评 顶一下，感谢分享！
anruoka3楼
2015-12-20 22:01
回复
五星好评 顶一下，感谢分享！
2015-12-20 23:24
回复
五星好评 顶一下，感谢分享！
2015-12-21 08:45
回复
五星好评 顶一下，感谢分享！
cycq0236楼
2015-12-21 09:37
回复
五星好评 顶一下，感谢分享！
虫虫80087楼
2015-12-21 09:58
回复
五星好评 
wslld8楼
2015-12-21 11:40
回复
五星好评 顶一下，感谢分享！
2015-12-21 13:24
回复
五星好评 顶一下，感谢分享！
yuanchang10楼
2015-12-21 14:43
回复
五星好评 顶一下，感谢分享！
liudr11楼
2015-12-22 08:37
回复
五星好评 顶一下，感谢分享！
lidehua12楼
2015-12-22 09:20
回复
五星好评 顶一下，感谢分享！
m20077015413楼
2015-12-22 11:36
回复
五星好评 顶一下，感谢分享！
quietdon14楼
2015-12-22 12:05
回复
五星好评 顶一下，感谢分享！
erickin15楼
2015-12-22 15:47
回复
五星好评 
shiwo11016楼
2015-12-23 10:13
回复
五星好评 顶一下，感谢分享！
dudubaobao17楼
2015-12-23 10:16
回复
五星好评 顶一下，感谢分享！
Bookaholic18楼
2015-12-23 13:35
回复
五星好评 顶一下，感谢分享！
ha166819楼
2015-12-23 21:06
回复
五星好评 顶一下，感谢分享！
独叶一支枪20楼
2016-01-06 18:19
回复
五星好评 顶一下，感谢分享！
jojozhanglei21楼
2016-01-07 13:45
回复
五星好评 顶一下，感谢分享！
go4322楼
2016-01-20 15:09
回复
五星好评 顶一下，感谢分享！
zjrzj52023楼
2016-01-28 11:02
回复
五星好评 顶一下，感谢分享！
heylixing24楼
2016-09-11 10:07
回复
五星好评 顶一下，感谢分享！
mahaijun25楼
2016-11-22 13:19
回复
五星好评 顶一下，感谢分享！
dawn51226楼
2016-12-11 15:19
回复
三星好评 顶一下，感谢分享！
zhfang85827楼
2022-11-21 17:44
回复
五星好评 顶一下，感谢分享！