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Group Name:
Plasma Laboratory

Group Leader:
Paul K. Chu

Affiliation:
City University of Hong Kong

Research Interest:
Using Plasma Immersion Ion Implantation - Deposition (PIII-D) technique to synthesize thin films and modify the surface properties of materials for biomedical applications.

Research Highlight:
Significant progress has been made to develop more biocompatible artificial heart, cardiovascular, and blood vessel stent materials and catheters. Crystalline silicon wafers can be made bioactive and conducive to the growth of apatite (bone) using hydrogen plasma implantation. This is a significant development enabling better integration of biosensors and bioMEMS with human tissues. Using patent pending plasma surface modification and thermal treatment technologies, the leaching of toxic Ni from NiTi is significantly mitigated while the shape memory and super-elastic properties can be tailored and retained. These inventions have led to another pending patent on a ¡°gradual correction"surgical technique that obviates the need for multiple surgeries for patients with spinal deformities like scoliosis and major back injuries. Plasma-sprayed TiO2 coatings have been made bioactive for the first time using a special fabrication process involving plasma implantation, nanofabrication technology, and UV irradiation. This is a significant development as plasma-sprayed titanium dioxide coatings have always been regarded as bio-inert. The novel nano-structured TiO2 coatings support the growth of bones and the work has profound impact on artificial prostheses and orthopedic materials.

Representative Publication:
1) P. K. Chu and X. Y. Liu (Editors), Biomaterials Fabrication and Processing Handbook, CRC Press / Taylor and Francis, Boca Raton, USA (2008).
2) J. Jiang, K. F. Huo, Z. W. Wu, et al., Silicon Induced DNA Damage Pathway and Its Modulation by Titanium Plasma Immersion Ion Implantation, Biomaterials, Vol. 29, No. 5, Pages: 544-550 (2008).
3) Zhang W, Chu PK, Ji JH, et al., Plasma Surface Modification of Poly vinyl chloride for Improvement of Antibacterial Properties, Biomaterials, Vol. 27, No. 1 Pages: 44-51 (2006).
4) X. Y. Liu, P. K. Chu, and C. X. Ding, Surface Modification of Titanium, Titanium Alloys, and Related Materials for Biomedical Applications, Materials Science and Engineering: Reports, Vol. 47, No. 2-4, Pages: 49-121 (2004).
5) P. K. Chu, J. Y. Chen, L. P. Wang, et al., Plasma Surface Modification of Biomaterials, Materials Science & Engineering: Reports, Vol. 36, No. 5-6, Pages: 143-206 (2002).

Webpage
http://www.cityu.edu.hk/ap/plasma/default.htm

¾ÙÀý2£º

Group Name:
The Schmidt Lab

Group Leader:
Christine E. Schmidt

Affiliation:
The University of Texas at Austin

Research Interest:
Semiconductor-Cell Interfaces; Biomimetic Synthetic Polymers; Natural-Based Biomaterials; Mechanisms of Cell Migration; Genetic Strategies for Tissue Repair

Research Highlight:
The group are working in collaboration with scientists with different backgrouds to better understand and repair tissues in the nervous and cardiovascular systems. Most of their current research is applied to the nervous system. They analysed various biomaterials (e.g., an electrically conducting polymer) that can be used to specifically stimulate, and guide, nerves to regrow their severed axons. They also studied the mechanisms of axon extension and nerve repair so that we can better design devices to help promote regeneration. Ultimately, nerve guidance channels (conduits) could be used to aid the repair of damaged peripheral nerves, such as would be required for facial and hand reconstruction, and ultimately, could be used to aid the regeneration of damaged spinal cord. In the cardiovascular system, they have used advanced cell culture approaches and a novel biomaterial scaffold (acellular vascular tissue) in an attempt to grow a living blood vessel. This vascular graft could ultimately be used for blood vessel reconstruction procedures (e.g., coronary artery bypass surgeries).

Representative Publication:
1) Guimard, N., N. Gomez, C.E. Schmidt (2007). Conducting Polymers in Biomedical Applications. Progress in Polymer Science. 32: 876-921.
2) Gomez, N., J.Y. Lee, J.D. Nickels, C.E. Schmidt (2007). Micropatterned Polypyrrole: Combination of Electrical and Topographical Characteristics for Stimulation of Cells. Advanced Functional Materials. 17: 1645-1653.
3) Sanghvi, A.B., K.P-H. Miller, A.M. Belcher, C.E. Schmidt (2005). Biomaterials functionalization using a novel peptide that selectively binds to an electrically conducting polymer. Nature Materials. 4: 496-502.
4) Winter, J.O., T.Y. Liu, B.A. Korgel, C.E. Schmidt (2001). Biomolecule-directed interfacing between semiconductor quantum dots and nerve cells. Advanced Materials.13: 1673-1677.
5) Schmidt, C.E., V.R. Shastri, J.P. Vacanti, and R. Langer (1997). Stimulation of neurite outgrowth using an electrically conducting polymer. Proceedings of the National Academy of Sciences. USA 94: 8948-8953.

Webpage:
http://www.bme.utexas.edu/faculty/schmidt/index.html

¾ÙÀý 3£º

Group Name:
Lieber Research Group

Group Leader:
Charles M. Lieber

Affiliation:
Harvard University

Research Interest (Specified):
Bio-Nano Interface: Biological/Chemical Sensing includes Single particle detection, Large-scale addressable arrays, Detection of disease biomarkers and Small molecule detection. Nanodevice-Cell Hybrid Structures. Assembly & Interconnection.

Research Highlight:
They have pioneered the underlying science and application of nanoscale field-effect transistors for real-time label-free electrical detection of biological and chemical species in fluid solution. Nanowire devices represent nearly ideal sensor elements since their sizes are matched to that of biological macromolecules. Current interests are focused primarily on detection within the context of biological systems, although our projects range from ones pushing fundamental limits of detection to application of these devices to important biological problems such as detection of diseases and biowarfare agents. They have an active and growing program investigating this interface in several types of cells with a goal of creating systems that can process information using the unique attributes of both the biological and nanoelectronic components. They are also pursuing efforts that merge other complementary attributes of biology and nanotechnology. They are exploring the use of specific biomolecular interactions available in protein and protein/small molecule systems, to direct in a highly specific manner reversible and irreversible organization of nanostructures. Moreover, they are exploring biological systems as a means for 'building' new types of two-dimensional and three-dimensional interconnections between functional nanostructures and nanostructure arrays.

Representative Publication:
1) F. Patolsky, B.P. Timko, G. Zheng and C.M. Lieber, "Nanowire-Based Nanoelectronic Devices in the Life Sciences," MRS Bull. 32, 142-149 (2007).
2) F. Patolsky, B.P. Timko, G. Yu, Y. Fang, A.B. Greytak, G. Zheng and C.M. Lieber, "Detection, Stimulation, and Inhibition of Neuronal Signals with High-Density Nanowire Transistor Arrays," Science 313, 1100-1104 (2006).
3) G. Zheng, F. Patolsky, Y. Cui, W.U. Wang and C.M. Lieber, "Multiplexed electrical detection of cancer markers with nanowire sensor arrays," Nat. Biotechnol. 23, 1294-1301 (2005).
4) W.U. Wang, C. Chen, K. Lin, Y. Fang and C.M. Lieber, "Label-free detection of small-molecule-protein interactions by using nanowire nanosensors," Proc. Natl. Acad. Sci. USA 102, 3208-3212 (2005).
5) F. Patolsky, G. Zheng, O. Hayden, M. Lakadamyali, X. Zhuang and C.M. Lieber, "Electrical detection of single viruses," Proc. Natl. Acad. Sci. USA 101, 14017-14022 (2004).

Webpage:
http://cmliris.harvard.edu/

¾ÙÀý 4£º

Group Name:
¹ú¼ÒÉúÎïҽѧ²ÄÁϹ¤³Ì¼¼ÊõÑо¿ÖÐÐÄ

Group Leader:
ÖÐÐÄÃûÓþÖ÷ÈΣºÕÅÐ˶°
ÖÐÐÄÖ÷ÈΣº¹ËÖÒΰ

Affiliation:
ÒÀÍÐÓÚËÄ´¨´óѧ

Research Interest:
Ö÷Òª´ÓÊÂÉúÎïҽѧ²ÄÁÏ¡¢Ò½ÓÃÖ²ÈëÌå¡¢×éÖ¯¹¤³Ì¡¢¿ØÊÍϵͳ¼°ÏȽøÖÆÔ칤ÒÕ¼¼ÊõµÄÑо¿¡¢¿ª·¢ºÍÓ¦ÓÃ

Research Highlight:
http://www.biomater.com/yanjiukaifachengguo.asp

Representative Publication:
http://www.biomater.com/shangyehuachanpin/chanpinshow.asp?c_id=25
http://www.biomater.com/shangyehuachanpin/chanpinshow.asp?c_id=26

Webpage:
http://www.biomater.com/


[ Last edited by zhangwj on 2009-7-21 at 23:33 ]
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LU Xiong Group

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Group Name:
LU Xiong Group

Group Leader:
LU Xiong (³ÐÛ)

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Affiliation:
Southwest Jiaotong University (Î÷ÄϽ»Í¨´óѧ)

Research Interest (Specified):
Biomineraliztion, Hydroxyapatite, Thermodynamics

Research Highlight:
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Representative Publication:
Journal Papers

1.      Xiong Lu, Yang Leng. Quantitative analysis of osteoblast behavior on microgrooved hydroxyapatite and titanium substrata, Journal of Biomedical Materials Research, 66A, 677-687, 2003 (SCI ÊÕ¼£¬Ó°ÏìÒò×Ó: 2.612) (Sep 2003).   

2.      Xiong Lu, Yang Leng. TEM study of calcium phosphate precipitation on bioactive titanium surfaces, Biomaterials, 25, 1779-1786, 2004. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 6.262) (May 2004).   

3.      Xiong Lu and Yang Leng, Theoretical analysis of calcium phosphate precipitation in simulated body fluid, Biomaterials, 26, 1097-1108, 2005. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 6.262). (April 2005)   

4.      Xiong Lu, Yang Leng, Xingdong Zhang,   Jinrui Xu,  Ling  Qin£¬Chun-wai Chan. Comparative study of osteoconduction on micromachined and alkali-treated titanium surfaces in vitro and in vivo, Biomaterials, 26, 1793-1801, 2005. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 6.262)( May 2005).  

5.      Xiong Lu, Yang Leng, Limin Jiang and Zhaowu Tian. Novel Techniques of Titanium Surface Patterning, Key Engineering Materials, 288-289, 619-624, 2005 (SCI ÊÕ¼).

6.      Xiong Lu, Yang Leng. Electrochemical micromachining of titanium surfaces for biomedical application. Journal of Materials Processing Technology 169, 173¨C178, 2005. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 0.816). (November 2005)

7.      Xiong Lu, Yang Leng, Lu-Tao Weng. TOF-SIMS study of bone mineralization on alkali-treated Ti alloy, Journal of Materials Science, 39, 6809-6811, 2004. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.081). (November, 2004)

8.      Yang Leng, Xiong Lu and Jiyong Chen. Identifying calcium phosphates formed in simulated body fluid by electron diffraction, Key Engineering Materials, Volume 254-256, (Bioceramics 16), Pages 339-342 (2004) (SCI ÊÕ¼).

9.      Xiong Lu, Zhanfeng Zhao, Yang Leng. Calcium phosphate crystal growth under controlled atmosphere in electrochemical deposition. Journal of Crystal Growth 284, 506¨C516, 2005. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.950). (November 2005)  

10.  Xiong Lu£¬Ying-bo Wang, Jian-xin Wang, Shu-xin Qu, Jie Weng, Ren-long Xin, Yang Leng, Calcium phosphate crystal growth under controlled environment through urea hydrolysis Journal of Crystal Growth 297,396¨C402, 2006. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.950). ( December 2006 )

11.  Xiong Lu, Zhanfeng Zhao, Yang Leng. Biomimetic calcium phosphate coatings on nitric-acid-treated titanium surfaces. Materials Science and Engineering C, 27, 700¨C708, 2007. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.486). ( May 2007)

12.  Xiong Lu, Ying-bo Wang; Yu-rong Liu; Jian-xin Wang, Shu-xin Qu, Bo Feng, Jie Weng, Preparation of HA/Chitosan composite coatings on alkali treated titanium surfaces through sol-gel techniques, Materials Letters£¬61, 3970¨C3973, 2007. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.625) July 2007

13.  Xiong Lu, Yingbo Wang, Xiudong Yang, Qiyi Zhang, Zhanfeng Zhao, Lu-Tao Weng and Yang Leng£¬ Spectroscopic analysis of titanium surface functional groups under various surface modification and their behaviors in vitro and in vivo, Journal of Biomedical Materials Research, 84A, 281-290, 2008. (February 2008) (SCI ÊÕ¼£¬Ó°ÏìÒò×Ó: 2.612)

14.  Xiong LU, Yang Leng, Qiyi Zhang, Electrochemical deposition of octacalcium phosphate micro-fiber/chitosan composite coatings on titanium substrates. Surface and Coatings Technology, 202, 3142¨C3147, 2008 (SCI ÊÕ¼£¬Ó°ÏìÒò×Ó: 1.678)£¨March 2008£©

15.  Xiong LU, Yang Leng, Comparison of the Osteoblast and Myoblast Behaviors on Hydroxyapatite Microgrooves Journal of Biomedical Materials Research B Applied Biomaterials, accepted, 2008. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.933)

16.  Hong-ping Zhang, Xiong Lu*, Li-ming Fang, Jie Weng, Nan Huang, Yang Leng, Molecular Dynamics Simulation of RGD Peptide Adsorption on Titanium Oxide Surfaces, Journal of Materials Science Materials in Medicine, 19:3437¨C3441, 2008,. (Corresponding Author) Nov, 2008.  (SCI ÊÕ¼£¬Ó°ÏìÒò×Ó: 1.581) µÚÒ»×÷ÕßΪ±¾ÎÄѧÉú

17.  Hongping Zhang, Xiong Lu*, Liming Fang, Shuxin Qu, Bo Feng, Jie Weng, Atomic-scale Interactions at the Interface of Biopolymer/Hydroxyapatite, Biomedical Materials. (Corresponding Author)  accepted. 2008(SCI ÊÕ¼, Ó°ÏìÒò×Ó:0.787) µÚÒ»×÷ÕßΪ±¾ÎÄѧÉú

18.  Hong-ping Zhang, Xiong Lu*, Yang Leng, Liming Fang, Shuxin Qu, Bo Feng, Jie Weng, Jianxin Wang£¬Molecular dynamics simulations on the interaction between polymers and hydroxyapatite with and without coupling agents, Acta Biomaterialia (Corresponding Author) accepted. 2008(SCI ÊÕ¼, Ó°ÏìÒò×Ó:3.113) µÚÒ»×÷ÕßΪ±¾ÎÄѧÉú

19.  Yingbo Wang, Xiong Lu*, Jing Zhao, Bo Feng, Jianxin Wang, Shuxin Qu, Jie Weng, Jianmin Chen, Preparation of Stable n-HA/ZrO2 Composite Coating by Pulsed Electrochemical Deposition, Rare Metal Materials and Engineering (In Chinese), 2008, accepted (Corresponding author) Âö³åµç»¯Ñ§³Á»ýÖÆ±¸n-HA/ZrO2¸´ºÏÍ¿²ã£¬Ï¡ÓнðÊô²ÄÁÏÓ빤³Ì (SCI ÊÕ¼£¬Ó°ÏìÒò×Ó: 0.286) µÚÒ»×÷ÕßΪ±¾ÎÄѧÉú

20.  Ying-bo Wang, Xiong Lu*, Bo Feng, Shu-xin Qu, Jie Weng, Jian-min Chen,Investigation of HA/chitosan composite coatings prepared by sol-gel on alkali treated titanium surfaces, Journal of Inorganic Materials (in Chinese), 2008, accepted (Corresponding author) îѱíÃæÖÆ±¸ôÇ»ùÁ×»Òʯ/¿Ç¾ÛÌǸ´ºÏÍ¿²ãÑо¿£¬ ÎÞ»ú²ÄÁÏѧ±¨(SCI ÊÕ¼£¬Ó°ÏìÒò×Ó: 0.498) µÚÒ»×÷ÕßΪ±¾ÎÄѧÉú

21.  Xiudong Yang, Xiong Lu, Qiyi Zhang, Xingdong Zhang, Zhongwei Gu, Jiyong Chen, BCP coatings on pure titanium plates by CD method£¬Materials Science and Engineering C, (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.486) 27 (2007) 781¨C786. 16 May 2007

22.  Qiyi Zhang, Yang Leng, Renlong Xin, Chaoyuan Wang, Xiong Lu, Jiyong Chen, An effective approach to activate 316L stainless steel for biomimetic coating of calcium phosphate: electrochemical pretreatment, Journal of Materials Science, (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.081) 42 (15): 6205-6211 AUG 2007.

23.  Qiyi Zhang, Yang Leng, Xiong Lu, Renlong Xin, Xiudong Yang, Jiyong Chen, Bioactive films on metallic surfaces for osteoconduction, Journal of Biomedical Materials Research: Part A, accepted. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 2.612)

24.  Jing Zhao, Suguang Xiao, Xiong Lu, Jianxin Wang and Jie Weng. A study on improving mechanical properties of porous HA tissue engineering scaffolds by hot isostatic pressing. Biomed Mater. 1(2006) 188-192. Dec 2006 (SCI ÊÕ¼, Ó°ÏìÒò×Ó:0.787)

25.  Chi Deng, Jie Weng, Xiong Lu, Shaobing Zhou, Jianxin Wan, Shuxin Qu, Bo, Feng, B, Mechanism of ultrahigh, elongation rate of poly(D,L-lactide)-matrix composite biomaterial containing nano-apatite fillers, Materials Letters, 62, 607-610, February 2008 (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.625)

26.  Jing Zhao, Xiong Lu, Jie Weng, Macroporous Ti-based composite scaffold prepared by polymer impregnating method with calcium phosphate coatings, Materials Letters , 62, 2921-2924. June 2008.  (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.625)

27.  Chi Deng, Jie Weng, Qingyi Cheng, Shaobin Zhou, Xiong Lu, Jianxin Wang, Shuxin Qu, Bo Feng, Xiaohong Li, Choice of dispersants for the nano-apatite filler of polylactide-matrix composite biomaterial, Current Applied Physics 7 (6): 679-682 SEP 2007. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.291)

28.  Chi Deng, Jie Weng, Xiong Lu, Shaobing. Zhou, Jianxin Wan, Shuxin Qu, Bo Feng, Xiaohong Li, Preparation and in vitro bioactivity of poly (D,L-lactide) composite containing hydroxyapatite nanocrystals, Materials Science and Engineering C 28 (2008) 1304¨C1310

29.  Zhoujun Wu, Bo Feng, Jie Weng, Shuxin Qu, Jianxin Wang, Xiong Lu£¬ Biomimetic apatite coatings on Titanium coprecipitated with cephradine and salviae miltlorrhizae£¬ Journal of Biomedical Materials Research: Part B-Applied Biomaterials£¬84B,486-492£¬February 2008. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.933)

30.  Feng Bo, Weng Jie, Qu shuxin, Lu Xiong, Wang Jianxin, Nano-stucturalized surface modification for biomedical titanium, Real Metal Materials and Engineering,36(10):1693-1695, Oct 2007. Ò½ÓÃîѱíÃæÄÉÃ׽ṹ»¯¸ÄÐÔ£¬Ï¡ÓнðÊô²ÄÁÏÓ빤³Ì(SCI ÊÕ¼, Ó°ÏìÒò×Ó: 0.286))

31.  Jianxin Wang, Huichuan Zhao, Shaobing Zhou, Xiong Lu, Bo Feng, Caihong Duan, Jie Weng, One-step in situ synthesis and characterization of sponge-like porous calcium phosphate scaffolds using a sol¨Cgel and gel casting hybrid process, J Biomed Mater Res, A: 2008 in press. (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 2.612)

32.  Shaolin Chen, Wenlong Liu, Zhijuan Huang, Xiaoguang Liu, Qiyi Zhang, Xiong Lu, The simulation of the electrochemical cathodic Ca-P deposition process Materials Science and Engineering  C, In Press, Accepted Manuscript, Available online 3 June 2008 (SCI ÊÕ¼, Ó°ÏìÒò×Ó: 1.486)

33.  Wang Yingbo, Xiong LU, Jianxin Wang, Shuxin Qu, Jie Weng, Synthesis of OCP Fibers and Their Characterization, Journal of Functional Materials and Devices, (EI ÊÕ¼) Oct 2007£¬05£¬Page 1-4. ÏËά״Á×Ëá°Ë¸Æµ¥¾§ÌåµÄºÏ³É·½·¨¼°ÐγɻúÀí£¬¹¦ÄܲÄÁÏÓëÆ÷¼þѧ±¨ Vol¡¤13,No¡¤5£¬ 2007Äê10ÔÂ

34.  Zhanfeng Zhao, Xiong Lu, and Yang Leng, Mechanism study of calcium phosphate deposition on titanium surface in simulated body fluid, Key Engineering Materials, Vols. 342-343 (2007) pp. 693-696  (EIÊÕ¼)

35.  Bo Feng, Jie Weng, Yu Liang, Shuxin Qu, Jianxin Wang, Xiong Lu. Fabrication of porous titania and porous calcium phosphate coatings on titanium surface Key Engineering Materials, Vols. 330-332 (2007) pp. 529-532  (EIÊÕ¼)

36.  Bo Feng, An Liu, Nan Wu, Jie Weng, Shuxin Qu, Jianxin Wang, Xiong Lu, Nano-HA coating on titanium surface fabricated by modulation of self-assembled monolayer and bovine serum albumin, Materials Science Forum Vols. 561-565 (2007) pp. 1529-1532 (EIÊÕ¼)

37.  Nan Wu, Jie Weng, Shuxin Qu, Jianxin Wang, Xiong LU, Bo Feng, Hydroxyapatite formation and protein absorption on triethyl phosphate modified titanium surface, Advanced Materials Research Vols. 26-28 (2007) pp. 797-800

38.  Huaqiang Rao, Jianxin Wang, Xiong Lu, Bo Feng and Jie Weng,  Immobilization of bovine serum albumin on titanium through plasma polymerization of allylamine and crylic acid, Key Engineering Materials Vols. 361-363 (2008) pp. 713-716  (EIÊÕ¼)

39.  Xiaobing Yang, Xiong Lu, Jingjing Ge, Jie Weng, Effect of a silane coupling agent on mechanical properties of hydroxyapatite/polycaprolactone composites Key Engineering Materials Vols. 361-363 (2008) pp. 531-534 (EIÊÕ¼)

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