| ²é¿´: 1164 | »Ø¸´: 21 | |||
[½»Á÷]
Silk Nanoparticles ÊÇʲô£¿
|
|||
|
ÕÒµ½Ò»ÆªÎÄÏ×pH-Dependent Anticancer Drug Release from Silk Nanoparticles£¬ÆäÖÐ Silk Nanoparticles²»Ã÷°×ʲôÒâ˼¡£cnkiÉϱȽ϶àÊǽâÊÍÊÇË¿ËØÄÉÃ׿ÅÁ££¬ÆäÓ¢ÎÄΪsilk fibroin nanoparticles£¬¸Ð¾õÕâÁ½¸ö²»ÊÇÒ»¸ö¸ÅÄî¡£ÊDz»ÊÇ´æÔÚʲô˿״ÄÉÃ׿ÅÁ£»ò²ÏË¿ÄÉÃ׿ÅÁ£µÈµÈ¡£Ò²²é¹ýÓ¢Îĵ쬶àÊÇsilk fibroin nanoparticles¡£²»ÖªµÀ¶þÕßÊÇ·ñΪͬһ¸ÅÄϣÍûÓÐÑо¿»òÖªµÀÕâ·½ÃæµÄǰ±²¸øÓèÖ¸µã£¬Äܹ»Ïêϸ˵һÏÂSilk NanoparticlesºÍsilk fibroin nanoparticlesµÈ¸ÅÄî¼°Ïà¹ØÎÊÌ⣬¸Ð¼¤²»¾¡¡£ ÒÔÏÂÊÇÕªÒª²¿·Ö£º Silk has traditionally been used as a suture material because of its excellent mechanical properties and biocompatibility. These properties have led to the development of different silk-based material formats for tissue engineering and regenerative medicine. Although there have been a small number of studies about the use of silk particles for drug delivery, none of these studies have assessed the potential of silk to act as a stimulus-responsive anticancer nanomedicine. This report demonstrates that an acetone precipitation of silk allows the formation of uniform silk nanoparticles (98 nm diameter, polydispersity index 0.109), with an overall negative surface charge (-33.6 +/- 5.8 mV), in a single step. Silk nanoparticles are readily loaded with doxorubicin (40 ng doxorubicin/[mu]g silk) and show pH-dependent release (pH 4.5> 6.0 > 7.4). In vitro studies with human breast cancer cell lines demonstrates that the silk nanoparticles are not cytotoxic (IC50 > 120 [mu]g mL-1) and that doxorubicin-loaded silk nanoparticles are able to overcome drug resistance mechanisms. Live cell fluorescence microscopy studies show endocytic uptake and lysosomal accumulation of silk nanoparticles. In summary, the pH-dependent drug release and lysosomal accumulation of silk nanoparticles demonstrate the ability of drug-loaded silk nanoparticles to serve as a lysosomotropic anticancer nanomedicine. |
» ²ÂÄãϲ»¶
Ò»Ö¾Ô¸ÖÐɽ´óѧÉúÎïѧ£¬295·Ö£¬ÇóAÇøµ÷¼Á
ÒѾÓÐ2È˻ظ´
ÇóÖú»¯ºÏÎïCDÊý¾ÝµÄ´¦Àí
ÒѾÓÐ0È˻ظ´
ÉúÎïÁ¦Ñ§Óë×éÖ¯¹¤³ÌѧÂÛÎÄÈóÉ«/·ÒëÔõôÊÕ·Ñ?
ÒѾÓÐ293È˻ظ´
¹ãÖÝÒ½¿Æ´óѧÉúÎïҽѧ¹¤³ÌѧԺ ÉúÎïҽѧ¹¤³Ì¹¤Ñ§-083100 ÕÐÉú
ÒѾÓÐ5È˻ظ´
Ò»Ö¾Ô¸ºþÄÏ´óѧ ÉúÎïѧ332·Ö Óйú½±+Ê¡¼¶
ÒѾÓÐ1È˻ظ´
ÃÀ¹úÄϼӴó(USC)ҩѧԺProf. Yong (Tiger) Zhang¿ÎÌâ×é³ÏƸ²©Ê¿ºó
ÒѾÓÐ0È˻ظ´
ºþ±±¹¤Òµ´óѧʳƷ¿ÆÑ§Ó빤³Ìϵ¿ÎÌâ×éÕÐÊÕ2026¼¶Ê³Æ·/ÉúÎïҽҩ˶ʿÉú£¨º¬µ÷¼Á£©
ÒѾÓÐ0È˻ظ´
2026Ä격ʿÉú×ÔÎÒÍÆ¼ö
ÒѾÓÐ1È˻ظ´
Ò»Ö¾Ô¸211ÉúÎïѧ£¨0710£©×Ü·Ö325Çóµ÷¼Á
ÒѾÓÐ2È˻ظ´
Çóµ÷¼ÁÍÆ¼ö
ÒѾÓÐ2È˻ظ´
» ±¾Ö÷ÌâÏà¹ØÉ̼ÒÍÆ¼ö: (ÎÒÒ²ÒªÔÚÕâÀïÍÆ¹ã)
» ÇÀ½ð±ÒÀ²£¡»ØÌû¾Í¿ÉÒԵõ½:
³ÖÐø´´ÒµÕߣ¬A8ÀëÒìÄÐÕ÷»é£¬ÊÂÒµÓöµ½Æ¿¾±£¬Ñ°ÕÒ´´ÒµÉú»î°éÂÂ
+1/461
µçÁ¦È«¹úÖØµãʵÑéÊÒ˫һÁ÷AÀ೤½Ñ§ÕßÍŶÓÕÐ2026ÄêÈ«ÈÕÖÆ²©Ê¿1Ãû£¨4ÔÂ3ÈÕ½ØÖ¹£©
+2/96
ÖÐɽ´óѧ»·¾³²ÄÁÏÍŶÓÕÐÆ¸
+1/85
»ªÄÏÀí¹¤-¹ãÖÐÒ½ÁªºÏÕÐÊÕÉúÎïҽѧÓë²ÄÁϽ»²æÑ§¿Æ²©Ê¿Éú
+1/82
¸£½¨Å©ÁÖ´óѧ²ÄÁϹ¤³ÌѧԺ¸ß·Ö×Ó²ÄÁÏ¿ÎÌâ×éÕÐÉú
+1/79
Ô¸Óö¼ûÄ㣬Óö¼û²»Ö¹²Á¼ç¶ø¹ýµÄÔµ·Ö
+1/74
É¢½ð±Ò£¬ÇóºÃÔË£¬×£ÃæÉÏ˳Àû£¡
+2/66
Çൺ¸ßУ Ñо¿ÉúÕÐÉú
+1/47
ÕÐÊÕ2026Äê²ÄÁÏÓ뻯¹¤×¨Ë¶µ÷¼Á£¬É½¶«Ê¡ÊôÖØµã´óѧ£¬¹ý¹ú¼ÒÏß¼´¿Éµ÷¼Á£¬Ãû¶î³ä×ã
+2/40
Ìì½ò³Ç½¨´óѧÕÐÊÕÎïÀí¡¢»¯Ñ§»òÕßÉúÎïµ÷¼ÁÉúÒ»Ãû£¬Ç°ÍùÌì½ò´óѧÁªºÏÅàÑø
+1/37
PBATÈܽâ×ö³ÉÈéÒº
+1/36
ÉϺ£½»´óÕÐÆ¸¸ß·Ö×Ó·½Ïò²©Ê¿ºó¼°¿ÆÑÐÖúÀí
+1/35
ÉϺ£½»Í¨´óѧÉòµÀÖǸ±½ÌÊÚÕÐÊÕ2026ÄêÁªÅ಩ʿ/˶ʿÑо¿Éú£¨Î¢ÄÉÆ÷¼þÓëÖÆÔì·½Ïò£©
+1/33
´ºÃß²»¾õÏþ
+1/26
ÀöˮѧԺ ²ÄÁÏÓëÄÜÔ´¹¤³ÌѧԺ ³Â½·ÉÀÏʦ¿ÎÌâ×é˶ʿÕÐÉú----²ÄÁÏÓ뻯¹¤×¨Òµ
+1/16
Õã½ÖÐÒ½Ò©´óѧ¸±Ð£³¤ÍŶÓÕÐÆ¸Ò©Ñ§/ÉúÎïÐÅϢѧµÈ·½Ïò¸ßУ½Ìʦ7Ãû£¬±¨ÃûͨµÀÒÑ¿ªÆô
+1/15
Ìì½ò¹¤Òµ´óѧ˫һÁ÷¸ßУÕв©Ê¿¡¢Ë¶Ê¿¡¢²©Ê¿ºó
+1/13
Öйú¿ÆÑ§ÔºÇൺÉúÎïÄÜÔ´Óë¹ý³ÌÑо¿Ëù¿ÆÑÐÖúÀí/¹¤³ÌʦÕÐÆ¸ÆôÊÂ
+1/7
Ìì½ò´óѧÀíѧԺ·ÖÀë·ÖÎö¼°¹¦ÄܲÄÁÏÑо¿×é
+1/2
¡°»úе¡¢²ÄÁÏ¡±ÕÐÉú
+1/1
7Â¥2015-11-17 19:28:16
22Â¥2016-03-28 21:50:08
¼òµ¥»Ø¸´
qinyaov2Â¥
2015-11-17 19:27
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
×£¸£
guoxintc3Â¥
2015-11-17 19:27
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë

Ö§³Ö
chenleiop4Â¥
2015-11-17 19:27
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë

×£¸£
yuduoj5Â¥
2015-11-17 19:27
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë

xiejiaf6Â¥
2015-11-17 19:28
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë

Ö§³Ö
dmbb8Â¥
2015-11-17 19:28
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
lanweip9Â¥
2015-11-17 19:28
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë

fangfengw10Â¥
2015-11-17 19:28
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë

xiachaz11Â¥
2015-11-17 19:28
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
×£¸£
liufeic12Â¥
2015-11-17 19:28
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
×£¸£
zhangxiaot13Â¥
2015-11-17 19:29
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë

Ö§³Ö
lanmengj14Â¥
2015-11-17 19:29
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
×£¸£
marlyn15Â¥
2015-11-17 19:30
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
×£¸£ ·¢×ÔСľ³æAndroid¿Í»§¶Ë
hubaolong37016Â¥
2015-11-17 19:31
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
¡£ ·¢×ÔСľ³æAndroid¿Í»§¶Ë
°×Ñ©·ÉÑï17Â¥
2015-11-17 19:32
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
^_^ ·¢×ÔСľ³æIOS¿Í»§¶Ë
quainyni18Â¥
2015-11-17 19:33
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
×£¸£
Èýˮè19Â¥
2015-11-17 19:33
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë
chenchenyf20Â¥
2015-11-17 19:33
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë

qingxuanf21Â¥
2015-11-17 19:33
»Ø¸´
¿§·È¿¨Å©(½ð±Ò+1): лл²ÎÓë














»Ø¸´´ËÂ¥
