| 查看: 940 | 回复: 4 | ||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||
咖啡卡农金虫 (正式写手)
|
[求助]
Silk Nanoparticles概念分不清楚 已有1人参与
|
|
|
找到一篇文献pH-Dependent Anticancer Drug Release from Silk Nanoparticles，其中 Silk Nanoparticles不明白什么意思。cnki上比较多是解释是丝素纳米颗粒，其英文为silk fibroin nanoparticles，感觉这两个不是一个概念。是不是存在什么丝状纳米颗粒或蚕丝纳米颗粒等等。也查过英文的，多是silk fibroin nanoparticles。不知道二者是否为同一概念，希望有研究或知道这方面的前辈给予指点，感激不尽。 以下是摘要部分： Silk has traditionally been used as a suture material because of its excellent mechanical properties and biocompatibility. These properties have led to the development of different silk-based material formats for tissue engineering and regenerative medicine. Although there have been a small number of studies about the use of silk particles for drug delivery, none of these studies have assessed the potential of silk to act as a stimulus-responsive anticancer nanomedicine. This report demonstrates that an acetone precipitation of silk allows the formation of uniform silk nanoparticles (98 nm diameter, polydispersity index 0.109), with an overall negative surface charge (-33.6 +/- 5.8 mV), in a single step. Silk nanoparticles are readily loaded with doxorubicin (40 ng doxorubicin/[mu]g silk) and show pH-dependent release (pH 4.5> 6.0 > 7.4). In vitro studies with human breast cancer cell lines demonstrates that the silk nanoparticles are not cytotoxic (IC50 > 120 [mu]g mL-1) and that doxorubicin-loaded silk nanoparticles are able to overcome drug resistance mechanisms. Live cell fluorescence microscopy studies show endocytic uptake and lysosomal accumulation of silk nanoparticles. In summary, the pH-dependent drug release and lysosomal accumulation of silk nanoparticles demonstrate the ability of drug-loaded silk nanoparticles to serve as a lysosomotropic anticancer nanomedicine. |
回复此楼» 猜你喜欢
美国南加大(USC)药学院Prof. Yong (Tiger) Zhang课题组诚聘博士后
已经有4人回复
-
反应产物总提不上量？聊聊无机焦磷酸酶在核酸合成里的实用价值
已经有0人回复
-
生物物理、生物化学与分子生物学论文润色/翻译怎么收费?
已经有275人回复
-
【经验分享】体外转录踩坑无数，挖到一款好用的国产 T7 RNA 聚合酶
已经有0人回复
-
体外转录 / PCR 总提不上产量？终于找到稳定好用的无机焦磷酸酶
已经有5人回复
-
[会议预告]2026生物医药产业发展大会
已经有0人回复
-
【产品测评分享】体外转录产量不理想、dsRNA 副产物高？T7 RNA 聚合酶实测体验
已经有4人回复
-
【交流】蛋白标签切除踩坑不断？聊聊 TEV 蛋白酶实操体会
已经有0人回复
-
【交流】SUMO 融合蛋白切标签踩坑？聊聊 SUMO 蛋白酶实操体会
已经有1人回复
» 本主题相关商家推荐: (我也要在这里推广)
5楼2015-10-30 23:23:37
2楼2015-10-30 08:00:32
紫毛猴子
铁虫 (小有名气)
- 应助: 1 (幼儿园)
- 金币: 1823.9
- 散金: 1100
- 红花: 1
- 帖子: 135
- 在线: 10.5小时
- 虫号: 3732640
- 注册: 2015-03-12
- 性别: GG
- 专业: 检验医学其他科学问题
【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
咖啡卡农: 金币+5, ★有帮助 2015-10-30 23:21:50
咖啡卡农: 金币+10 2015-10-31 22:49:41
感谢参与，应助指数 +1
咖啡卡农: 金币+5, ★有帮助 2015-10-30 23:21:50
咖啡卡农: 金币+10 2015-10-31 22:49:41
|
其实是一个概念啦 发自小木虫Android客户端 |
3楼2015-10-30 21:38:08
咖啡卡农
金虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 2301.9
- 散金: 483
- 红花: 5
- 帖子: 887
- 在线: 426.6小时
- 虫号: 3091753
- 注册: 2014-03-26
- 性别: GG
- 专业: 肿瘤发生
4楼2015-10-30 23:22:10
