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Dear Dr. XX,

Thank you for submitting your manuscript entitled "xxxxxxxx" to Nanomedicine: Nanotechnology, Biology, and Medicine.

However, we can not continue processing your submission until you make the following changes to your submission:

1.* We do not use "Highlights"; please remove that from the submission.(Õâ¸öºÃ˵£¬È¥µô¼´¿É)

2.* Upload each table (as a word processing document file) and each figure (in .tif or .eps format) as a separate file.£¨Õâ¸öÒ²ºÃ˵£¬Ô­À´ÎÒ¶¼ÊÇ·ÅÔÚwordÀïÉÏ´«µ¥¸öÎļþ£¬ÏÖÔÚ¸øËûԭͼ¾ÍÐУ©
description so that the figure number appears at the top of the page of the file that is created by the system. £¨Ö÷ÒªÊÇÕâ¸ö£¬¿´²»¶®°¡£¬ item descriptionÔÚÄÄÀÔõô¼ÓÈ룿£©

* Move the following to the title page: This work was supported by Natural Science Foundation project (xxxx),National Distinguished Young Scholars grant (xxxxx), Key Basic Research,"Hundred Talents Program" (xxxx), NIH/NIMHD xxx and USAMRMC xxx-x-x-xx grants. Chinese Academy of Science, Grant No.xxxx.(Õⲿ·ÖÎÒÔ­ÏÈÊÇдÔÚÖÂлÀïÃæÁË£¬ÏÖÔÚÒÆµ½Ê×Ò³£¬ÖÂÐ»Ð´É¶ÄØ£¿»¹ÓоÍÊÇÊ×Ò³ÒѾ­Ð´¹ýÁËÒ»¶Î»°¹ØÓÚÀûÒæ³åÍ»µÄÎÊÌâµÄ£¬ÓбØÒªÔÙд»ù½ðÖ§³ÖÂð£¿)

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                                                                                                           Publishable statement
We confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial
*Add the figure number to the item We confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.
We confirm that we have given due consideration to the protection of intellectual property associated with this work and that there are no impediments to publication, including the timing of publication, with respect to intellectual property. In so doing we confirm that we have followed the regulations of our institutions concerning intellectual property.
We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us.  
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