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[资源] Pharmaceutical Dosage Forms and Drug Delivery，SECOND EDITION

Table of Contents

Drug Development and Regulatory Process
Pharmacy Math and Statistics
Pharmaceutical and Formulation Considerations
Biopharmaceutical and Physiological Considerations
Complexation and Protein Binding
Chemical Kinetics and Stability
Interfacial Phenomena
Rheology
Disperse System Basics
Surfactants and Micelles
Pharmaceutical Suspensions
Pharmaceutical Emulsions
Compounding Principles and Practices
Pharmaceutical Solutions
Powders and Granules
Tablets
Capsules
Injectable Dosage Forms
Semisolid Dosage Forms
Inserts, Implants and Devices
Pharmaceutical Polymers
Pharmaceutical Calculations
Compounding Principles and Practices
Drug Delivery Systems
Protein and Peptide-Based Dosage Forms
Biotechnology Based Dosage Forms
Answers to Review Questions
Index

These are exciting times in the pharmacy world. There has been, in fact, no other
time in the history of pharmaceutical sciences that the entire world was fascinated as
it is now by the spectacular advances in dosage form design and drug delivery, gene
therapy, and nanotechnology. As you prepare to learn more about different dosage
forms and related sciences, the University of Tennessee College of Pharmacy would
like to assist you by introducing a new textbook, Pharmaceutical Dosage Forms
and Drug Delivery. We are excited to have Ram I. Mahato, PhD, professor of phar-
maceutical sciences at the University of Tennessee Health Science Center, write this
important textbook for learning the basic principles of pharmaceutics, dosage form
design, and drug delivery. This book has been meticulously designed to meet the
requirements of professional students in this field. To include some new chapters and
revise and expand the remaining ones, Mahato thoughtfully invited Ajit S. Narang,
who utilized his expertise in making this new edition well suited to addressing phar-
maceutics and drug delivery challenges in the twenty-first century.
Although there are numerous books on the science of pharmaceutics and dosage
form design, those books cover different areas of the discipline and do not provide
an integrated approach, forcing students to refer to multiple textbooks to develop an
overall understanding of the basic physicochemical principles and their applications
to the design and development  of  different pharmaceutical dosage forms. Unlike
other books, this book provides a unified perspective of the overall field to the stu -
dents as well as faculty.
Apart from the physicochemical principles and their application in the design
of dosage forms, students should also be exposed to the latest developments in the
application of biomaterials as well as protein and nucleic acid–based pharmaceuti-
cal dosage forms and therapeutics and various biotechnology-based developments.
Exposure of students to these latest developments is critical to the successful training
of future pharmacists, because these therapeutic modalities and options are likely to
be clinically significant in the future. All these principles and applications are inte -
grated in this textbook so that the student develops a better and overall understand-
ing of the principles involved in dosage form design and drug delivery. Moreover,
this book also provides review questions and answers at the end of each chapter to
improve students’ learning objectives.
Dick R. Gourley, PharmD
University of Tennessee College of Pharmacy
Memphis, Tennessee

Preface
This book is designed as a textbook for teaching the basic principles of pharmaceu-
tics, dosage form design, and drug delivery to doctor of pharmacy (PharmD) students
in the United States and bachelor of pharmacy (BPharm) students in other countries.
Although there are numerous books on the science of pharmaceutics and dosage
form design, including Martin’s Physical Pharmacy and Pharmaceutical Sciences
by  Sinko,  Physicochemical  Principles  of  Pharmacy  by  Florence  and  Attwood,
Pharmaceutics:  The  Science  of  Dosage  Form  Design  by  Aulton,  Theory  and
Practice of Contemporary Pharmaceutics by Ghosh and Jasti, and Pharmaceutical
Sciences by Remington, these books cover different areas of the discipline and do
not provide an integrated approach to the students. Although these books have been
used for teaching dosage form and drug delivery principles to PharmD students for
a long time, they each cover different aspects of the field. This leads to the students
as well as the teachers having to refer to many textbooks to develop an overall under-
standing of the basic physicochemical principles and their applications to the design
and development of different pharmaceutical dosage forms. In an attempt to over-
come these challenges, this book provides a unified perspective of the overall field to
the students as well as instructors.
The students need to know the basic physicochemical principles, the application
of these principles to the design of dosage forms, and the relevance of these prin-
ciples to the biopharmaceutical aspects of drugs. Another important aspect of teach-
ing that is urgently needed in our PharmD curricula is to expose students to the latest
developments in the application of biomaterials as well as protein and nucleic acid–
based pharmaceutical dosage forms and therapeutics, and various biotechnology-
based developments. Various books that are currently taught to students miss these
latest developments in the field of pharmaceutics and drug delivery. Exposure of stu -
dents to these latest developments is critical to the successful training of future phar-
macists, because these therapeutic modalities and options are likely to be clinically
significant in the future. All these principles and applications needed to be integrated
in a single textbook so that the student develops a better and overall understanding of
the principles involved in dosage form design and drug delivery. This book covers an
in-depth discussion on what physiochemical parameters can be used for the design,
development, and evaluation of biotechnological dosage forms for the delivery of
proteins, peptides, oligonucleotides, and genes.
What is new in the second edition of Pharmaceutical Dosage Forms and Drug
Delivery? Although the first edition was single-handedly written by Ram I. Mahato,
he  realized  certain  deficiencies  in  the  book  and  hence  he  invited  Ajit  S.  Narang
to write two new chapters, one on pharmacy math and statistics and the other on
powders and granules, and to assist in significantly revising and expanding a major-
ity of the remaining chapters. This edition has also been thoughtfully reorganized
into the following three parts: Introduction, Physicochemical Principles, and Dosage
Forms.  Additionally,  many  of  the  chapters  were  restructured  and  new  contents
were included. We also identified and corrected certain errors to our “Answers to
Review Questions.” What you now have is a new book that can serve as a textbook
for PharmD students and as a valuable resource for the novice in the pharmaceutics
and drug delivery fields.

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2015-09-25 23:04:42, 13.76 M