| 查看: 9127 | 回复: 27 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
Master-Fandy铜虫 (小有名气)
|
[交流]
论文大修后，投稿状态从with editor直接变成decision in process，神马情况…… 已有23人参与
|
||
|
各位虫友，大家好！ 小妹前段时间投了一篇论文，一个多月收到一审意见——大修，大概花了两个星期的时间，该补的理论实验也补充了，个人感觉整体上满足了审稿人的要求。9月1日返修回去，当天状态就变成with editor，3天后状态直接变成decision in process，好像没有经过under review过程。麻烦各位虫友们，帮忙分析一下具体情况和原因，自己都莫名的恐慌和紧张……目前还没收到任何结果。 另附审稿意见如下： Reviewer #1: Ursolic acid(UA), the derivative of oleanolic acid, is widely studied due to numerous pharmacological activities. The author had synthesized a series of ursolic acid derivatives, which is a break ground result. In this paper, simulation approach is employed to explore the effects of binding affinity for inhibitory activities, which is an innovative work for the study on anti-diabetic properties of the hydrolyzation analogues of UA. While, in order to verify that simulation model can explain the experimental results, some work needs to be complemented Major Issues: 1. In the section of “structure activity relationship” The author had got the value of IC50 by experiments, and calculated the binding energy to understand the relationship between binding mode and bioactivity. While Quantitative Structure-Activity and Relationships (QSAR) is the only persuasive tool to explain which structures play the important role in enhancing the inhibition activity. In order to increase the confidence level of simulation results, the author has to demonstrate the QSAR equations to support their conclusions. The math expression of QSAR equation can be obtained by regression analysis. Only after the regression analysis work is completed, we can know which site in UA plays the important role for inhibition activity. 2. In the section of “molecular docking mode”, the author only listed the calculation results, but no parameter settings. The author has to list the major parameters, such as which kind of force field, which algorithm were used Minor Issues: 3. Typo: In Figure 1. 3a - 8a & 3b – 8b should be replaced by 3a - 10a & 3b – 10b 4. Use idiomatic English expression: Line 1: November 14 ---> November 14th; Line 29: Expose 5. Some abbreviate needs full name, such as: Line 92: DMSO Reviewer #2: This manuscript reports the synthesis and evaluation of a group of ursolic acid derivatives for anti-diabetic applications. The authors presented in vitro anti-diabetic activity and modeling studies to demonstrate their structure-bioactivity relationships, which would be useful for developing more effective alpha-glucosidase inhibitors. The manuscript is also well-written. I would recommend an acceptance in PLOS One after minor revisions. 1. The authors need to discuss what are the rationals of the overall molecular structure design and what are the objectives and hypotheses between each group analysis for molecules of interest. 2. It would be helpful if the authors can briefly discuss about the control (Acarbose) selection, since there are so many available inhibitors out there. 3. In the caption of Fig. 4, "liphilic" should be "Lipophilic". The authors need to carefully check over the manuscript to avoid typos. |
回复此楼» 猜你喜欢
307求调剂
已经有3人回复
-
265求调剂
已经有3人回复
-
301求调剂
已经有10人回复
-
303求调剂
已经有7人回复
-
材料工程（专）一志愿985 初试335求调剂
已经有4人回复
-
299求调剂
已经有6人回复
-
083200学硕321分一志愿暨南大学求调剂
已经有3人回复
-
初始318分求调剂（有工作经验）
已经有3人回复
-
二本跨考郑大材料306英一数二
已经有3人回复
-
化学求调剂
已经有5人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 论文终于收稿，写一下我艰辛的投稿历程。
已经有172人回复
- 论文大修后返回 编辑发邮件说拒稿 可是投稿系统里显示的状态是under review
已经有21人回复
- 论文大修重投后，Decision Letter Being Prepared 状态求助
已经有18人回复
- 论文二次修改后审稿完成已经15天，编辑还没给消息，要催吗？
已经有7人回复
- 论文大修后进入decision in process，求好运！
已经有86人回复
- 博士期间第三篇论文，美国生理学杂志-细胞生理学，大修后直接接收，攒人气，散金币
已经有240人回复
- 最近比较关注论文状态，祈祷ING
已经有3人回复
- 历时一年，大修两次，今天收到领域编辑来信Moderate Revise，大家分析下录用的可能性
已经有129人回复
- SCI，EI投稿状态变化
已经有8人回复
- 论文接收，发金币攒RP，并有小疑问
已经有100人回复
- 《有机化学》投稿，大修
已经有1人回复
- 论文大修后送审，审稿已经结束了，祈福能被录用
已经有88人回复
- 论文大修后提交，投稿状态出现Securing Reviewer
已经有6人回复
- 第一篇SCI投稿，论文要求大修后已经一个月了，焦急等待中
已经有38人回复
Master-Fandy
铜虫 (小有名气)
- 应助: 1 (幼儿园)
- 金币: 2548.6
- 红花: 1
- 帖子: 213
- 在线: 70.2小时
- 虫号: 1459566
- 注册: 2011-10-25
- 性别: GG
- 专业: 药物化学
6楼2015-09-05 00:12:35
sunnyboy555
至尊木虫 (知名作家)
- 应助: 66 (初中生)
- 金币: 27874.1
- 散金: 316
- 红花: 23
- 帖子: 5478
- 在线: 86.2小时
- 虫号: 3635672
- 注册: 2015-01-09
- 性别: GG
- 专业: 流体力学
2楼2015-09-04 22:16:21
3楼2015-09-04 22:25:27
cjinfor
铁杆木虫 (文坛精英)
- 应助: 24 (小学生)
- 金币: 22527.1
- 散金: 100
- 帖子: 14046
- 在线: 295.3小时
- 虫号: 2918840
- 注册: 2014-01-07
- 专业: 美学
4楼2015-09-04 22:29:33
