| 查看: 9131 | 回复: 27 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
Master-Fandy铜虫 (小有名气)
|
[交流]
论文大修后，投稿状态从with editor直接变成decision in process，神马情况…… 已有23人参与
|
||
|
各位虫友，大家好！ 小妹前段时间投了一篇论文，一个多月收到一审意见——大修，大概花了两个星期的时间，该补的理论实验也补充了，个人感觉整体上满足了审稿人的要求。9月1日返修回去，当天状态就变成with editor，3天后状态直接变成decision in process，好像没有经过under review过程。麻烦各位虫友们，帮忙分析一下具体情况和原因，自己都莫名的恐慌和紧张……目前还没收到任何结果。 另附审稿意见如下： Reviewer #1: Ursolic acid(UA), the derivative of oleanolic acid, is widely studied due to numerous pharmacological activities. The author had synthesized a series of ursolic acid derivatives, which is a break ground result. In this paper, simulation approach is employed to explore the effects of binding affinity for inhibitory activities, which is an innovative work for the study on anti-diabetic properties of the hydrolyzation analogues of UA. While, in order to verify that simulation model can explain the experimental results, some work needs to be complemented Major Issues: 1. In the section of “structure activity relationship” The author had got the value of IC50 by experiments, and calculated the binding energy to understand the relationship between binding mode and bioactivity. While Quantitative Structure-Activity and Relationships (QSAR) is the only persuasive tool to explain which structures play the important role in enhancing the inhibition activity. In order to increase the confidence level of simulation results, the author has to demonstrate the QSAR equations to support their conclusions. The math expression of QSAR equation can be obtained by regression analysis. Only after the regression analysis work is completed, we can know which site in UA plays the important role for inhibition activity. 2. In the section of “molecular docking mode”, the author only listed the calculation results, but no parameter settings. The author has to list the major parameters, such as which kind of force field, which algorithm were used Minor Issues: 3. Typo: In Figure 1. 3a - 8a & 3b – 8b should be replaced by 3a - 10a & 3b – 10b 4. Use idiomatic English expression: Line 1: November 14 ---> November 14th; Line 29: Expose 5. Some abbreviate needs full name, such as: Line 92: DMSO Reviewer #2: This manuscript reports the synthesis and evaluation of a group of ursolic acid derivatives for anti-diabetic applications. The authors presented in vitro anti-diabetic activity and modeling studies to demonstrate their structure-bioactivity relationships, which would be useful for developing more effective alpha-glucosidase inhibitors. The manuscript is also well-written. I would recommend an acceptance in PLOS One after minor revisions. 1. The authors need to discuss what are the rationals of the overall molecular structure design and what are the objectives and hypotheses between each group analysis for molecules of interest. 2. It would be helpful if the authors can briefly discuss about the control (Acarbose) selection, since there are so many available inhibitors out there. 3. In the caption of Fig. 4, "liphilic" should be "Lipophilic". The authors need to carefully check over the manuscript to avoid typos. |
回复此楼» 猜你喜欢
346求调剂[0856]
已经有7人回复
-
一志愿山大07化学 332分 四六级已过 本科山东双非 求调剂！
已经有3人回复
-
310求调剂
已经有3人回复
-
机械专硕299求调剂至材料
已经有4人回复
-
070300化学319求调剂
已经有7人回复
-
08工科 320总分 求调剂
已经有6人回复
-
一志愿天津大学化学工艺专业（081702）315分求调剂
已经有12人回复
-
307求调剂
已经有3人回复
-
265求调剂
已经有3人回复
-
301求调剂
已经有10人回复
25楼2015-09-08 23:34:38
sunnyboy555
至尊木虫 (知名作家)
- 应助: 66 (初中生)
- 金币: 27874.1
- 散金: 316
- 红花: 23
- 帖子: 5478
- 在线: 86.2小时
- 虫号: 3635672
- 注册: 2015-01-09
- 性别: GG
- 专业: 流体力学
2楼2015-09-04 22:16:21
3楼2015-09-04 22:25:27
cjinfor
铁杆木虫 (文坛精英)
- 应助: 24 (小学生)
- 金币: 22527.1
- 散金: 100
- 帖子: 14046
- 在线: 295.3小时
- 虫号: 2918840
- 注册: 2014-01-07
- 专业: 美学
4楼2015-09-04 22:29:33
