| 查看: 1473 | 回复: 17 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
开发一种新药的惊人花费（The truly staggering cost of inventing new drugs）
|
|||
|
原文链接：http://bioluminor.biomart.cn/news/2770272.htm During the Super Bowl, a representative of the pharmaceutical company Eli Lilly posted the on the company’s corporate blog that the average cost of bringing a new drug to market is $1.3 billion, a price that would buy 371 Super Bowl ads, 16 million official NFL footballs, two pro football stadiums, pay of almost all NFL football players, and every seat in every NFL stadium for six weeks in a row. This is, of course, ludicrous. The average drug developed by a major pharmaceutical company costs at least $4 billion, and it can be as much as $11 billion. The drug industry has been tossing around the $1 billion number for years. It is based largely on a study (supported by drug companies) by Joseph DiMasi of Tufts University. It’s a nice number for the pharmaceutical industry, because it seems to justify the idea that medicines should be pricey (and increasingly, they can be very pricey, costing tens of thousands of dollars per patient per year) without making it seem that inventing new medicines is so expensive an endeavor as to be ultimately futile. But as Bernard Munos of the InnoThink Center for Research In Biomedical Innovation has noted, just adjusting that estimate for current failure rates results in an estimate of $4 billion in research dollars spent for every drug that is approved. But Munos showed me another figure, where he divided each drug company’s R&D budget by the average number of drugs approved. This was far more dramatic. The range of money spent is stunning. AstraZeneca has spent $12 billion in research money for every new drug approved, as much as the top-selling medicine ever generated in annual sales; Amgen spent just $3.7 billion. At $12 billion per drug, inventing medicines is a pretty unsustainable business. At $3.7 billion, you might just be able to make money (a new medicine can probably keep generating revenue for ten years; invent one a year at that rate and you’ll do well). There are lots of expenses here. A single clinical trial can cost $100 million at the high end, and the combined cost of manufacturing and clinical testing for some drugs has added up to $1 billion. But the main expense is failure. AstraZeneca does badly by this measure because it has had so few new drugs hit the market. Eli Lilly spent roughly the same amount on R&D, but got twice as many new medicines approved over that 15 year period, and so spent just $4.5 billion per drug. Wanting to make this even more rigorous, Forbes (that would be Scott DeCarlo and me) took Munos’ count of drug approvals for the major pharmas and combined it with their research and development spending as reported in annual earnings filings going back fifteen years, pulled from a Thomson Reuters database using FactSet. We adjusted all the figures for inflation. Using both drug approvals and research budgets since 1997 keeps the estimates being skewed by short-term periods when R&D budgets or drug approvals changed dramatically. The range of money spent is stunning. AstraZeneca has spent $12 billion in research money for every new drug approved, as much as the top-selling medicine ever generated in annual sales; Amgen spent just $3.7 billion. At $12 billion per drug, inventing medicines is a pretty unsustainable business. At $3.7 billion, you might just be able to make money (a new medicine can probably keep generating revenue for ten years; invent one a year at that rate and you’ll do well). There are lots of expenses here. A single clinical trial can cost $100 million at the high end, and the combined cost of manufacturing and clinical testing for some drugs has added up to $1 billion. But the main expense is failure. AstraZeneca does badly by this measure because it has had so few new drugs hit the market. Eli Lilly spent roughly the same amount on R&D, but got twice as many new medicines approved over that 15 year period, and so spent just $4.5 billion per drug. |
回复此楼» 猜你喜欢
北京协和医学院杰青课题组招聘科研助理
已经有0人回复
-
求助中国药典1995年版、二部
已经有0人回复
-
药物学论文润色/翻译怎么收费?
已经有274人回复
-
在线求助，急！！！请问哪里可以做磁性纳米材料的高分辨透射电镜的测试表征呀？
已经有5人回复
-
北京协和医学院杰青课题组招聘科研助理
已经有0人回复
-
福州大学李兴淑教授课题组急招博士研究生
已经有9人回复
-
Liquid Chromatography-Mass Spectrometry Analysis of Small Interfering RNAs
已经有1人回复
-
求助https://www.pnas.org/doi/10.1073/pnas.2535777123 全文
已经有0人回复
-
加巴喷丁胶囊激素6月超限杂质结构
已经有4人回复
-
中药检测种决明子、枳实、水蛭、茯苓品种检测问题交流
已经有1人回复
» 抢金币啦！回帖就可以得到:
-
散金祈福
+5/1055
-
基金祈福
+1/959
-
散金祈福
+3/774
-
何不食肉糜
+1/472
-
南方医科大学|生物材料与医学工程团队诚聘科研助理
+2/238
-
基金申请小调查！预祝申请必定中中中！！祈福！！！
+5/230
-
散金求好运
+1/190
-
诚征另一半
+1/168
-
坐标北京诚征男友
+1/112
-
美国University of Texas at Arlington土木结构工程方向2027年春季全奖博士招生
+1/84
-
哈尔滨工业大学（校本部）电子与信息工程学院2027级博士招生
+1/63
-
那年春暖花开，今朝如梦初醒 —— 北漂十五载，相亲十年，归乡孑然一身
+1/62
-
上海交通大学张航课题组招聘博士后（电化学能量存储与转换）
+1/43
-
瑞典-博后-固态电池-粘结剂-锂离子电池方向
+1/31
-
专利优先审查新办法出了，哪些成果值得走快速预审通道？
+1/27
-
流放岭南浮肿了求救
+1/19
-
上海交通大学化学化工学院倪伟焱课题组招收2027年申请考核制博士生（电催化+高分子）
+1/12
-
2027环境工程博士申请
+1/7
-
南方医科大学深圳医院陈烨/余涛教授课题组联合培养博士后招聘
+1/5
-
南京大学 智能驱动与感知材料实验室 诚招申请考核博士生/科研助理/博士后
+1/4
9楼2015-09-01 08:14:29
7楼2015-08-31 16:02:44
10楼2015-09-01 08:19:15
11楼2015-09-14 11:50:36
