24小时热门版块排行榜    

查看: 600  |  回复: 5
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

wwzzchem

至尊木虫 (著名写手)

[求助] 查一下是否SCI检索已有2人参与

作者:
Haiying Li, Lilan Ma, Xiaxia Li, Xin Cui, Wenzhi Yang
文题:
A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique
期刊名:
European Journal of Pharmaceutical Sciences
期刊年份:
2015
卷(期),起止页码:
77 , 154–160
数据库名称:
ScienceDirect(Elsevier)(Cell Press)
回复此楼

» 猜你喜欢

» 本主题相关价值贴推荐,对您同样有帮助:

已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

回归自然

金虫 (小有名气)

【答案】应助回帖

感谢参与,应助指数 +1
IF 3.35,牛。今年影响因子不错

[ 发自小木虫客户端 ]
3楼2015-08-27 16:59:54
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
查看全部 6 个回答

ccbbbz

银虫 (小有名气)

【答案】应助回帖

★ ★ ★ ★ ★
感谢参与,应助指数 +1
wwzzchem: 金币+5, ★★★★★最佳答案 2015-08-27 22:31:27
A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique.
作者:Li, Haiying; Ma, Lilan; Li, Xiaxia; Cui, Xin; Yang, Wenzhi; Shen, Shigang; Chen, Mingmao
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
卷:77 页:154-60
DOI:10.1016/j.ejps.2015.06.016
出版年:2015-Sep-18 (Epub 2015 Jun 17)
摘要
The purpose of this study was to improve the solubility and bioavailability of glimepiride (GLMP) by utilizing hydrotropy technique. Meglumine (MU) as a hydrotrope could form the stable complex with glimepiride. The optimal glimepiride and meglumine (GLMP-MU) complex powder was obtained by using lyophilization. GLMP-MU powder was characterized by Fourier transform infrared spectroscopy (FT IR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). The formation of hydrogen bond between glimepiride and meglumine was confirmed by FT IR. The XRD studies indicated the amorphous state of glimepiride was appeared in the GLMP-MU. The DSC results were further confirmed GLMP-MU complex was prepared successfully. Moreover, the in vitro drug release rate of GLMP-MU powder was dramatically faster than that of glimepiride. Meanwhile, the AUC of GLMP-MU solution at an i.g./or i.v. dose of 5mg/kg in rat was significantly higher than that of the glimepiride suspensions. Together our results showed that hydrotropy technique was a simple and effective method to increase the solubility of glimepiride.
Copyright 2015 Elsevier B.V. All rights reserved.
关键词
关键词列表:Bioavailability; Complex; Glimepiride; Hydrotropy technique; Meglumine
作者信息
地址:College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China.
文献信息
文献类型:Journal Article
语种:English
PubMed ID:26093052
NLM 唯一 ID:9317982
创建日期: 27 Jul 2015         
电子出版:17 Jun 2015
国家/地区: Netherlands
ISSN:1879-0720
其他信息
分主题子库:Index Medicus
状态:In-Data-Review
2楼2015-08-27 16:52:55
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

wwzzchem

至尊木虫 (著名写手)

引用回帖:
2楼: Originally posted by ccbbbz at 2015-08-27 16:52:55
A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique.
作者:Li, Haiying; Ma, Lilan; Li, Xiaxia; Cui, Xin; Yang, Wenzhi; Shen, Shigang; Chen, Mingm ...

这表明已经检索了,是吗?
4楼2015-08-27 22:36:33
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

ccbbbz

银虫 (小有名气)

引用回帖:
4楼: Originally posted by wwzzchem at 2015-08-27 22:36:33
这表明已经检索了,是吗?...

是的,已经检索了
5楼2015-08-28 15:22:24
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[找工作] 杭电、天津科技、青农和宁波工程学院如何选? +10 味道很好啊 2024-06-13 20/1000 2024-06-16 07:43 by 味道很好啊
[考博] 34岁读博士晚吗 +26 emitdne 2024-06-13 26/1300 2024-06-16 07:16 by liyeqik
[教师之家] 关于2023的收入 +33 小龙虾2008 2024-06-10 34/1700 2024-06-15 23:01 by zeolitess
[基金申请] 博后面上今天有bug可以看到是否资助? +20 lyfbangong 2024-06-12 31/1550 2024-06-15 21:18 by since—2010
[基金申请] 关于博后基金的bug问题 +6 lxr1991 2024-06-14 9/450 2024-06-15 21:17 by since—2010
[考博] 上海交大招收材料化学方向科研助理/“申请考核”博士(请勿回复帖子或站内投条) +3 灵梦and紫 2024-06-12 4/200 2024-06-15 20:58 by 1822836277
[基金申请] 希望今年自己国自然面上项目和老婆青年项目能中! +5 恐龙爸爸 2024-06-14 5/250 2024-06-15 20:36 by wanghuawei
[教师之家] 请问事业编制和年薪制冲突吗? +6 ZHONGWU_U 2024-06-14 6/300 2024-06-15 20:16 by Ermito
[基金申请] 博后基金,博管会会提前知道消息吗? +3 yuyiang 2024-06-13 3/150 2024-06-15 19:52 by Lynn212
[基金申请] 博后基金,以往的结果点不开,怎么回事呢?最后一次机会了,两次都没中前面。 +7 kyukitu 2024-06-14 13/650 2024-06-15 06:46 by 我是王小帅
[基金申请] 面上基金有一个(两个)C是不是就没戏了.... 5+3 zzzm116 2024-06-13 17/850 2024-06-14 22:26 by lzt8076
[考研] 物理化学一对一辅导 +3 林大diao 2024-06-12 5/250 2024-06-14 20:57 by 林大diao
[基金申请] 化学会年会改成一年开一次了? +5 babu2015 2024-06-12 13/650 2024-06-14 10:46 by babu2015
[论文投稿] 投稿kbs被拒后,系统提供的推荐的其他期刊有用吗? +3 chenrui2015 2024-06-10 3/150 2024-06-14 10:30 by Tr.sjx1997
[基金申请] 工材E10口函评结束了吗 10+3 我1的飞翔 2024-06-13 5/250 2024-06-14 06:35 by nono2009
[基金申请] 连续两年医学口青年项目初审体会 +11 进击的荣耀 2024-06-09 18/900 2024-06-13 17:27 by 进击的荣耀
[硕博家园] 科研求助 +5 杲www 2024-06-12 6/300 2024-06-13 16:16 by 姓李名明
[硕博家园] 机械研究生如何拿到年薪40+w +13 阿巴阿巴哦哦 2024-06-11 15/750 2024-06-13 15:40 by 113745685
[考博] 博导选择 +3 bing85977 2024-06-12 3/150 2024-06-13 15:34 by 我是邱尧
[硕博家园] 求助 +6 LYWwrz 2024-06-09 9/450 2024-06-11 13:12 by powerhours
信息提示
请填处理意见