24小时热门版块排行榜    

查看: 599  |  回复: 5
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

wwzzchem

至尊木虫 (著名写手)

[求助] 查一下是否SCI检索已有2人参与

作者:
Haiying Li, Lilan Ma, Xiaxia Li, Xin Cui, Wenzhi Yang
文题:
A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique
期刊名:
European Journal of Pharmaceutical Sciences
期刊年份:
2015
卷(期),起止页码:
77 , 154–160
数据库名称:
ScienceDirect(Elsevier)(Cell Press)
回复此楼

» 猜你喜欢

» 本主题相关价值贴推荐,对您同样有帮助:

已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

ccbbbz

银虫 (小有名气)

【答案】应助回帖

★ ★ ★ ★ ★
感谢参与,应助指数 +1
wwzzchem: 金币+5, ★★★★★最佳答案 2015-08-27 22:31:27
A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique.
作者:Li, Haiying; Ma, Lilan; Li, Xiaxia; Cui, Xin; Yang, Wenzhi; Shen, Shigang; Chen, Mingmao
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
卷:77 页:154-60
DOI:10.1016/j.ejps.2015.06.016
出版年:2015-Sep-18 (Epub 2015 Jun 17)
摘要
The purpose of this study was to improve the solubility and bioavailability of glimepiride (GLMP) by utilizing hydrotropy technique. Meglumine (MU) as a hydrotrope could form the stable complex with glimepiride. The optimal glimepiride and meglumine (GLMP-MU) complex powder was obtained by using lyophilization. GLMP-MU powder was characterized by Fourier transform infrared spectroscopy (FT IR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). The formation of hydrogen bond between glimepiride and meglumine was confirmed by FT IR. The XRD studies indicated the amorphous state of glimepiride was appeared in the GLMP-MU. The DSC results were further confirmed GLMP-MU complex was prepared successfully. Moreover, the in vitro drug release rate of GLMP-MU powder was dramatically faster than that of glimepiride. Meanwhile, the AUC of GLMP-MU solution at an i.g./or i.v. dose of 5mg/kg in rat was significantly higher than that of the glimepiride suspensions. Together our results showed that hydrotropy technique was a simple and effective method to increase the solubility of glimepiride.
Copyright 2015 Elsevier B.V. All rights reserved.
关键词
关键词列表:Bioavailability; Complex; Glimepiride; Hydrotropy technique; Meglumine
作者信息
地址:College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China.
文献信息
文献类型:Journal Article
语种:English
PubMed ID:26093052
NLM 唯一 ID:9317982
创建日期: 27 Jul 2015         
电子出版:17 Jun 2015
国家/地区: Netherlands
ISSN:1879-0720
其他信息
分主题子库:Index Medicus
状态:In-Data-Review
2楼2015-08-27 16:52:55
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

ccbbbz

银虫 (小有名气)

引用回帖:
4楼: Originally posted by wwzzchem at 2015-08-27 22:36:33
这表明已经检索了,是吗?...

是的,已经检索了
5楼2015-08-28 15:22:24
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
相关版块跳转 我要订阅楼主 wwzzchem 的主题更新
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[论文投稿] 投稿被一个审稿人恶意评审了怎么样? +5 1chen 2024-06-14 7/350 2024-06-15 23:15 by xy66xy
[教师之家] 关于2023的收入 +33 小龙虾2008 2024-06-10 34/1700 2024-06-15 23:01 by zeolitess
[考博] 上海交大招收材料化学方向科研助理/“申请考核”博士(请勿回复帖子或站内投条) +3 灵梦and紫 2024-06-12 4/200 2024-06-15 20:58 by 1822836277
[找工作] 江西双非一本和四川双一流高校如何选择? 5+7 寒山敲钟 2024-06-12 22/1100 2024-06-15 20:00 by LittleBush
[基金申请] 博后基金,博管会会提前知道消息吗? +3 yuyiang 2024-06-13 3/150 2024-06-15 19:52 by Lynn212
[教师之家] 我们学院常年位居 各学院 倒数第二。专业撤销的话,在编者有什么补偿? +13 河西夜郎 2024-06-09 14/700 2024-06-15 19:44 by LittleBush
[博后之家] 山东大学(青岛)“天然药物生物智造”课题组 招聘“博士后”(年薪20.4-55.6万元) +3 第二种态度 2024-06-11 5/250 2024-06-15 17:56 by 小懂事k
[有机交流] 车间生产,真空度很高,温度很高,但减压蒸馏速度很慢。 10+12 召唤鬼泣lL 2024-06-13 35/1750 2024-06-15 16:14 by 老钱秀
[基金申请] BO4的YQ答辩通知发布了吗? +6 博学笃行 2024-06-11 6/300 2024-06-15 16:04 by 悲催科研狗
[论文投稿] 求机械类四区sci推荐 5+3 迷茫小旷 2024-06-14 4/200 2024-06-15 11:25 by bobvan
[基金申请] 博后基金,以往的结果点不开,怎么回事呢?最后一次机会了,两次都没中前面。 +7 kyukitu 2024-06-14 13/650 2024-06-15 06:46 by 我是王小帅
[论文投稿] 投了一篇4区的SCI,审稿人一个拒稿,一个小修,编辑给了大修。 +9 安稳22123 2024-06-13 10/500 2024-06-14 23:45 by jurkat.1640
[食品] 食品博士导师 +6 小李醒yy 2024-06-11 9/450 2024-06-14 23:37 by 小李醒yy
[基金申请] E12面上申请 +4 汉风之遗 2024-06-13 4/200 2024-06-14 15:28 by 天外飞去来
[有机交流] ππ堆积会发生在有机溶剂中吗 5+3 zibuyu0420 2024-06-13 4/200 2024-06-14 14:17 by 小肉干
[找工作] 应届大龄土博教职选择,石河子大学和广西大学 10+4 茅山老道士 2024-06-10 31/1550 2024-06-14 10:40 by ChmistryCHEN
[论文投稿] 投稿后发现其他作者的邮箱填错了该怎么办呀 10+4 在飞的猪 2024-06-13 6/300 2024-06-14 04:45 by 小虫子咔咔
[有机交流] 原料反应完了,怎么知道是产物还是中间体 +6 小胡在努力 2024-06-11 8/400 2024-06-13 13:33 by 091602
[找工作] 成都产品质量检测研究院 200+3 鲸鱼663 2024-06-11 8/400 2024-06-13 08:10 by 加纳居士
[基金申请] 博后特助这周出结果吗?往年都是啥时候啊? +13 jsqy 2024-06-12 17/850 2024-06-12 19:55 by Lynn212
信息提示
请填处理意见