应《网络安全法》要求，自2017年10月1日起，未进行实名认证将不得使用互联网跟帖服务。为保障您的帐号能够正常使用，请尽快对帐号进行手机号验证，感谢您的理解与支持！

24小时热门版块排行榜    

小木虫论坛-学术科研互动平台 » 学术交流区 » 论文投稿 » 交流 » 色谱B投稿交流
321/1返回列表
查看: 1528  |  回复: 31
只看楼主 @他人 存档 新回复提醒 (忽略) 收藏    在APP中查看

wtpierce

木虫 (著名写手)

[交流] 色谱B投稿交流

外审完后判定大修，各位帮我看看，有希望吗
Comments:

Dear Dr. Xueying,
Thank you for submitting your manuscript to J. Chrom. B. Based on the received referee report I request a major revision of your manuscript. There are notably important parameters of your study that should be clarified according to current regulatory guidelines. Please address all comments and submit a revised version of your study for further review.   
Sincerely yours,
Rainer Bischoff
Editor in Chief


Reviewer #1: The article is interesting and revision is required in improving the method development and validation as per USFDA JULY 2015 recommendation for method validation of drugs and biologic.
Please find the queries as enlisted
(i) Method robustness needs to be evaluated and discussed in method development
(ii) Comparative and contrasting model of bio-distribution has not been cited . A reference model is required to be incorporated so that the study findings are anchored to the extant knowledge domain
(iii) Need to provide statistical methods to  confirm matrix effect in different lots have no impact on method. Statistical support as per USFDA JULY 2015 recommendation for method validation of drugs and biologic clearly states for such confirmatory analysis.
(iv) Figures with T-joint to show there is no ion suppression or enhancement at the retention time of analyte is important and should be essentially discussed.
(v) Metabolites monitoring needs to be discussed.
(vi) Discussion on using ESI mode of mass spectrometry, employing liquid -liquid chromatography and reason for selecting Inertsil ®ODS3 C18 column for separation has not been clarified.
(vii) Syntax errror and English usage needs to be improved throughout the paper.
(viii) Authors should argue the potential of being a high-throughput method due to achieving  separation from both endogenous and exogenous interfering compounds.
(ix) Quality of method should be discussion with clarity against the reported literature.
(x) However, considering the merit of the research highlights,  the article has a potential to fit in short communication category after revision. Though the article couldn't be accepted in current form, it is suggested that authors work on the major points as discussed above and resubmit for consideration.

Once again, thanking you for contributing in bio-distribution field and best wishes for your future endeavors.
回复此楼

» 猜你喜欢

» 本主题相关价值贴推荐，对您同样有帮助:

» 抢金币啦！回帖就可以得到:

查看全部散金贴
1楼 2015-08-21 12:30:18
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

铁拳虎

至尊木虫 (知名作家)
★
wtpierce(金币+1): 谢谢参与
祝楼主万事顺意，心想事成，羊年发大财！
赞一下 回复此楼
2楼2015-08-21 12:30:55
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

vincent_hpax

铁杆木虫 (职业作家)
★
wtpierce(金币+1): 谢谢参与
major revision嘛 楼主 好好修改 针对审稿人意见逐一认真修改 祝好！
赞一下 回复此楼
9楼2015-08-21 13:24:22
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

纳米之心

木虫 (文坛精英)
★
wtpierce(金币+1): 谢谢参与
祝福楼主
回复此楼
11楼2015-08-21 13:41:59
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
简单回复
石头阿呆3楼
2015-08-21 12:46   回复  
wtpierce(金币+1): 谢谢参与
..
211001124楼
2015-08-21 12:51   回复  
wtpierce(金币+1): 谢谢参与
ellen_rock5楼
2015-08-21 12:55   回复  
wtpierce(金币+1): 谢谢参与
!
dmbb6楼
2015-08-21 12:57   回复  
wtpierce(金币+1): 谢谢参与
LifePursuit7楼
2015-08-21 12:58   回复  
wtpierce(金币+1): 谢谢参与
clszdy8楼
2015-08-21 13:23   回复  
wtpierce(金币+1): 谢谢参与
litzmath10楼
2015-08-21 13:33   回复  
wtpierce(金币+1): 谢谢参与
hydzp12楼
2015-08-21 13:43   回复  
wtpierce(金币+1): 谢谢参与
a
ZloveA13楼
2015-08-21 13:56   回复  
wtpierce(金币+1): 谢谢参与
祝福
shinyzd14楼
2015-08-21 13:56   回复  
wtpierce(金币+1): 谢谢参与
支持
deweini15楼
2015-08-21 14:01   回复  
wtpierce(金币+1): 谢谢参与
xiejf16楼
2015-08-21 14:09   回复  
wtpierce(金币+1): 谢谢参与
一
miaojiabing17楼
2015-08-21 14:23   回复  
wtpierce(金币+1): 谢谢参与
gltsycw18楼
2015-08-21 14:25   回复  
wtpierce(金币+1): 谢谢参与
gltsycw19楼
2015-08-21 14:28   回复  
hyena.20楼
2015-08-21 14:38   回复  
wtpierce(金币+1): 谢谢参与
天涯201221楼
2015-08-21 14:38   回复  
wtpierce(金币+1): 谢谢参与
xiaomaya204622楼
2015-08-21 14:41   回复  
wtpierce(金币+1): 谢谢参与
laom201323楼
2015-08-21 14:43   回复  
wtpierce(金币+1): 谢谢参与
小虫199224楼
2015-08-21 14:43   回复  
wtpierce(金币+1): 谢谢参与
sz_kebaoyuan25楼
2015-08-21 14:45   回复  
wtpierce(金币+1): 谢谢参与
小蚂蚁199726楼
2015-08-21 14:47   回复  
wtpierce(金币+1): 谢谢参与
tingting198227楼
2015-08-21 14:50   回复  
wtpierce(金币+1): 谢谢参与
小蚂蚁199828楼
2015-08-21 14:53   回复  
wtpierce(金币+1): 谢谢参与
jixiangbao29楼
2015-08-21 14:56   回复  
wtpierce(金币+1): 谢谢参与
wdxmu30楼
2015-08-21 15:00   回复  
wtpierce(金币+1): 谢谢参与
。 [ 发自手机版 https://muchong.com/3g ]
交大狂人31楼
2015-08-21 15:05   回复  
wtpierce(金币+1): 谢谢参与
00
假大空32楼
2015-08-21 15:16   回复  
wtpierce(金币+1): 谢谢参与
相关版块跳转 我要订阅楼主 wtpierce 的主题更新
321/1返回列表
普通表情 龙 兔 虎 猫 高级回复 (可上传附件)
信息提示
关闭
请填处理意见
关闭