24小时热门版块排行榜    

查看: 626  |  回复: 6
当前主题已经存档。
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

wuselht

铁杆木虫 (正式写手)

[交流] 请问这里最后一个单词base是什么意思?

Sucinimidyl esters are used, inter alia, as activated acyl derivatives, in particular when other acylating agents, such as acid chlorides or anhydrides, cannot be employed on account of the lability of startingmaterials or final products. This applies particularly in the field of peptide chemistry. For coupling a covalent peptide bond, an activated carboxyl component is necessary. The previously most frequently used method for carboxyl activation is basedon the formation of succinimidyl esters by reaction of the corresponding carboxylic acid with carbodiimides, such as, for example, N,N'-dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide. The disadvantage in this process lies, on the one hand, inthe coupling reagent DCC on account of its allergenicity and of the high price, and, on the other hand, in the by-product N,N'-dicyclohexylurea obtained here, which firstly contaminates the succinimidyl ester and secondly has to be disposed of. For these reasons, it was attempted to replace the system DCC/N-hydroxysuccinimide. Possible alternatives are systems of the type halophosphoric acid ester/N-hydroxysuccinimide/base.[/size]就是这里最后一个base,是啥意思?我不是学生物的为了有语境,把全部一段都写了,网上搜的一段专利文献,留下来我也好找得到
http://www.patentgenius.com/patent/5929251.html
回复此楼

» 猜你喜欢

已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

qfzhang

银虫 (小有名气)


xyklmu(金币+1,VIP+0):感谢答复
N-羟基琥珀酰亚胺 nhs,刚才Google了一下,补充
4楼2008-08-19 13:57:43
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
查看全部 7 个回答

wuselht

铁杆木虫 (正式写手)

谢谢回复,还不是很清楚,烦请继续指点

顶上去如果是碱的话,能帮忙明确一下,指的是什么碱呢?
N-甲基马啡啉怎样?
马上评分
2楼2008-08-19 11:21:26
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

qfzhang

银虫 (小有名气)


wuselht(金币+1,VIP+0):谢谢
一种合成偶联经常用到的试剂,琥珀酰胺,简称nhs, 一般和edc配合使用,edc是碳二亚胺
3楼2008-08-19 13:54:01
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

wuselht

铁杆木虫 (正式写手)

N-hydroxysuccinimide/base.
楼上的说的是前面那个N-hydroxysuccinimide吧,我问的是后面的base
5楼2008-08-19 21:53:14
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
普通表情 高级回复 (可上传附件)
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[基金申请] 2026国自然函评费到账 +3 羊腰板 2026-08-21 3/150 2026-08-21 19:42 by kulium
[基金申请] 科研孤儿太难了 +16 我4大白菜 2026-08-20 17/850 2026-08-21 19:07 by sakuraai
[基金申请] 时间戳又变了 +13 wuchongjun 2026-08-20 19/950 2026-08-21 17:21 by 紫杉醇
[基金申请] filecode,4个jtjc了 +11 ziyangfang 2026-08-19 14/700 2026-08-21 16:51 by applepetty
[基金申请] 让我中一个面上吧! +11 大萍1987 2026-08-20 13/650 2026-08-21 14:48 by 20120902066
[基金申请] 人气不行了 +7 fansofjerry 2026-08-21 7/350 2026-08-21 14:13 by Vivilian
[基金申请] 只有每年这种时候来逛逛小木虫 +23 yaoyewhu2008 2026-08-20 25/1250 2026-08-21 12:19 by Poppy1104
[基金申请] 今天基金会出结果吗?20260819 +15 kkkl_v 2026-08-19 16/800 2026-08-21 11:22 by 365372687
[基金申请] 应该是下周三26日公布了吧? +4 哈哈蛤? 2026-08-21 4/200 2026-08-21 10:58 by Vivilian
[基金申请] 放榜前的不淡定 40+4 snowwithsea 2026-08-19 13/650 2026-08-21 08:30 by 北京莱茵编辑
[基金申请] 时间戳今天,20号变了 +4 archvillain 2026-08-20 4/200 2026-08-21 08:10 by gatelove
[基金申请] 今天系统多次维护,明天很可能放榜! +10 zju2000 2026-08-16 11/550 2026-08-20 20:02 by cl479861084
[基金申请] 重要消息,中午系统在维护 +11 yuleib84 2026-08-18 12/600 2026-08-20 11:09 by xskun
[教师之家] 为什么余额宝的年化利率越来越低?主要原因有哪些? +5 瞬息宇宙 2026-08-15 5/250 2026-08-19 20:23 by super2002521
[基金申请] 今天放榜吗? +14 布布和一二 2026-08-19 15/750 2026-08-19 18:07 by gltch
[基金申请] 2027广东省杰青 +4 奶牛小黑 2026-08-15 10/500 2026-08-19 11:02 by wanfengnew
[基金申请] 朋友圈看到的 +6 wangzilk 2026-08-18 8/400 2026-08-19 10:55 by Haru815
[基金申请] 明天放榜? +5 Shxjjxjkx 2026-08-18 5/250 2026-08-18 18:14 by -大大大大大-
[基金申请] 今天维护系统维护 祝所有人 高中 +8 gjjjzhong 2026-08-18 9/450 2026-08-18 13:01 by 家与远方
[基金申请] 93BebMhtakh前后11位开头都是大写 +4 且听虎啸 2026-08-17 5/250 2026-08-18 00:49 by 蔡棒棒菂
信息提示
请填处理意见