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转录因子 已有2人参与
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| 本人并非生物学出身，对转录因子不是很了解，现在看文献时有一个疑惑。作者实验用转录组测序方法证实响应细胞外营养元素A缺乏的若干上调基因是由转录因子B调控的，而A缺乏条件下转录因子B的基因表达量没有发生改变。请问转录因子B可能是怎样调控这些基因表达的呢（这个在文献中并没有提到过）？谢谢 |
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gaoxiang6803
铜虫 (小有名气)
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2楼2015-08-11 12:31:31
3楼2015-08-11 14:07:41
gaoxiang6803
铜虫 (小有名气)
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4楼2015-08-12 07:41:03
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小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
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hello everyone, i have finished differential expression analysis of my RNA-seq data and retrieve the transcripts of transcription factors(TF) from differentially expressed unigenes and non differentially expressed unigenes. then i have categorized those TFs to different TF families. then i realized there are many TFs sequences which blong to the same TF family overly expressed than some other TF families, some parts of my data: TF_families Differential Unchanged AP-2 0 2 ARID 2 5 bHLH 8 67 CG-1 1 1 COE 0 2 CP2 0 4 CSD 0 4 CSL 0 1 CUT 1 6 DDT 0 1 DM 0 6 E2F 0 3 ETS 2 10 Fork_head 2 22 . . . and i wanna find most expressed TF families in my DE TF sets. i saw a several papers analysed this kind of data and they used fisher's exact test for that. i searched some materials about fisher's exact test, but in those example fisher's test used for 2x2 contingency table, no more. here i still have no idea how to use fisher's test to my data. so could anyone explain to me how could i do solve this and is there any tool i can use for the analysis ? any suggestion would be highly appreciated. |
5楼2015-09-06 19:08:44