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2Â¥2015-06-24 10:20:22
fatewu
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3Â¥2015-06-24 10:20:44
sapphires008
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4Â¥2015-06-24 10:42:02
sunshan4379
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Ðľ²_ÒÀÈ»: ½ð±Ò+3, лл»ØÌû 2015-06-24 21:20:39
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Shuang-Huang-Lian Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice Involving Anti-Inflammatory and Antioxidative Activities ×÷Õß:Fang, L (Fang, Lei); Gao, Y (Gao, Yuan); Liu, F (Liu, Fen); Hou, R (Hou, Rui); Cai, RL (Cai, Run-Lan); Qi, Y (Qi, Yun)[ 1 ] EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE ÎÄÏ׺Å: 283939 DOI: 10.1155/2015/283939 ³ö°æÄê: 2015 ²é¿´ÆÚ¿¯ÐÅÏ¢ ÕªÒª Shuang-Huang-Lian (SHL) is a common traditional Chinese preparation extracted from Lonicerae Japonicae Flos, Scutellariae Radix, and Fructus Forsythiae. In this study, we demonstrate the anti-inflammatory and antioxidative effects of SHL on lipopolysaccharide-(LPS-) induced acute lung injury (ALI) in mice. SHL reduced the lungwet/dryweight ratio, lowered the number of total cells in the bronchoalveolar lavage fluid, and decreased the myeloperoxidase activity in lung tissues 6 h after LPS treatment. It also inhibited the overproduction of proinflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6) in the bronchoalveolar lavage fluid. Histological studies demonstrated that SHL attenuated LPS-induced interstitial edema, hemorrhage, and the infiltration of neutrophils into the lung tissue. Moreover, SHL could also enhance the superoxide dismutase and catalase activities, increase the reduced glutathione content, and decrease the malondialdehyde content. The present results suggest that SHL possesses antiinflammatory and antioxidative properties that may protect mice against LPS-induced ALI. ¹Ø¼ü´Ê KeyWords Plus:RESPIRATORY-DISTRESS-SYNDROME; INFLAMMATORY MEDIATORS; DAMAGE; SEPSIS; CELLS ×÷ÕßÐÅÏ¢ ͨѶ×÷ÕßµØÖ·: Qi, Y (ͨѶ×÷Õß) ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China. µØÖ·: ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ [ 1 ] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ [ 2 ] Peking Union Med Coll, Beijing 100193, Peoples R China µç×ÓÓʼþµØÖ·:yqi@implad.ac.cn »ù½ð×ÊÖúÖÂл »ù½ð×ÊÖú»ú¹¹ ÊÚȨºÅ National and Beijing Natural Science Foundation of China 81274163 7142112 National S&T Major Project and Scientific Researchers Aiding Enterprise Item from the Ministry of Science and Technology of the People's Republic of China 2012ZX09301-002-001 2014ZX09201022-006 ²é¿´»ù½ð×ÊÖúÐÅÏ¢ ³ö°æÉÌ HINDAWI PUBLISHING CORPORATION, 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA Àà±ð / ·ÖÀà Ñо¿·½Ïò:Integrative & Complementary Medicine Web of Science Àà±ð:Integrative & Complementary Medicine ÎÄÏ×ÐÅÏ¢ ÎÄÏ×ÀàÐÍ:Article ÓïÖÖ:English Èë²ØºÅ: WOS:000355184700001 ISSN: 1741-427X eISSN: 1741-4288 ÆÚ¿¯ÐÅÏ¢ Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports® ÆäËûÐÅÏ¢ IDS ºÅ: CJ0RG Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 28 Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0 |

5Â¥2015-06-24 11:02:50
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sapphires008: ½ð±Ò+10, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2015-06-24 20:17:05
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6Â¥2015-06-24 18:39:36
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7Â¥2015-06-24 18:52:52
fatewu
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Ðľ²_ÒÀÈ»: ½ð±Ò+3, лл»ØÌû 2015-06-24 21:21:08
Ðľ²_ÒÀÈ»: ½ð±Ò+3, лл»ØÌû 2015-06-24 21:21:08

8Â¥2015-06-24 19:42:39
sapphires008
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9Â¥2015-06-24 20:19:20













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