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[资源] Drug Discovery Series- Handbook of Assay Development in Drug Discovery

Drug Discovery Series- Handbook of Assay Development in Drug Discovery

Multiwell assays for drug discovery have become a staple of the scientiﬁc community. This has
been led by the need to screen targets more rapidly and with more efﬁciency than in previous years.
This has also been led by advances in chemistry allowing parallel or multiplex chemical synthesis
to provide more compounds for screening. These multiwell assay formats are both in vitro and cell
based and include a mixture of simple enzyme assays as well as those more complex, such as cell
imaging.  This  handbook  is  designed  to  serve  as  a  reference  guide  to  all  of  those  in  discovery
research  who  are  developing  assays,  as  well  as  those  in  the  academic  world  who  wish  to  know
what is available to perform the assay they want as well as where to ﬁnd those tools. This book
will provide general guidelines as well as speciﬁc examples of each assay system. These include
radiometric assays, ﬂuorescent-based assays, reporter assays, and others, for such targets as kinases,
proteases, nuclear receptors, and G-protein–coupled receptors (GPCRs). The book includes chapters
from assay developers in the pharmaceutical as well as in the vendor community. It is meant as a
general  guidebook  that  one  can  take  to  the  bench.  It  includes  descriptions  of  methods,  exact
protocols  used  to  perform  such  methods,  and  troubleshooting  tools.  I  hope  that  you  will  ﬁnd  it
beneﬁcial and that use of it will provide the information and guidance that you seek.

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2015-06-08 21:04:13, 8.54 M