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【答案】应助回帖
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感谢参与，应助指数 +1
feiyun1001(心静_依然代发): 金币+10, 感谢应助 2015-05-31 20:53:15
心静_依然: LS-EPI+1, 感谢应助 2015-05-31 20:53:58
Risk of nasopharyngeal carcinoma associated with polymorphic lactotransferrin haplotypes
作者:Zhou, YH (Zhou, Yanhong)[ 1 ] ; Wang, W (Wang, Wei)[ 2 ] ; Zheng, DW (Zheng, Danwei)[ 1 ] ; Peng, SP (Peng, Shuping)[ 1 ] ; Xiong, W (Xiong, Wei)[ 1 ] ; Ma, J (Ma, Jian)[ 1 ] ; Zeng, ZY (Zeng, Zhaoyang)[ 1 ] ; Wu, MH (Wu, Minghua)[ 1 ] ; Zhou, M (Zhou, Ming)[ 1 ] ; Xiang, JJ (Xiang, Juanjuan)[ 1 ] 更多内容
MEDICAL ONCOLOGY
卷: 29 期: 3 页: 1456-1462
DOI: 10.1007/s12032-011-0079-6
出版年: SEP 2012
查看期刊信息
摘要
Lactotransferrin (LTF) is a component of the nonspecific immune system, having antimicrobial properties against bacteria, fungi, and several viruses. The gene coding for LTF is polymorphic, with the occurrence of several common alleles in the general population. Our previous study found that LTF inhibited nasopharyngeal carcinoma (NPC) cell proliferation in vitro and in vivo. To better understand one possible mechanism of LTF-mediated antitumor activity in NPC cells, in the present study, we investigated the distribution of LTF gene polymorphisms (rs1126477, rs1126478, rs2073495, and rs9110) in NPC and revealed whether these polymorphisms were associated with LTF gene expression. It was found that rs2073495 and rs9110 were correlated significantly with NPC. The frequency of CC genotype was higher and GG or TT genotype was lower, in NPC patients compared with that in the control group (P < 0.05, chi(2) = 8.73 and 9.33, respectively). CC genotype is the risk factor for NPC. Haplotype analyses indicated that NPC patients had lower rate of 'A-G-G-T' haplotype (constructed with rs1126477, rs1126478, rs2073495, and rs9110) compared with controls (P = 4.12 x 10(-6) < 0.001, chi(2) = 21.25). The population with 'A-G-G-T' haplotype had 0.322-fold risk to be NPC. The expression of LTF gene was high in NPC tissues and control tissues with 'A-G-G-T' haplotype compared with these without its. These findings suggested that rs2073495 and rs9110 could play important roles in NPC physiological processes.
关键词
作者关键词:Nasopharyngeal carcinoma; Genetic variation; Haplotype diversity; Lactotransferrin; Gene expression
KeyWords Plus:SINGLE-NUCLEOTIDE POLYMORPHISMS; CANDIDATE MOLECULAR MARKERS; HUMAN LACTOFERRIN; GENE-EXPRESSION; RECOMBINANT ADENOVIRUS; SUSCEPTIBILITY LOCUS; MICROARRAY ANALYSIS; TUMOR-SUPPRESSOR; CHROMOSOME 3P21; LINKAGE
作者信息
通讯作者地址: Li, GY (通讯作者)
显示增强组织信息的名称 Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China.
地址:
显示增强组织信息的名称 [ 1 ] Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China
显示增强组织信息的名称 [ 2 ] Cent S Univ, Xiangya Hosp 3, Changsha 410083, Hunan, Peoples R China
电子邮件地址:ligy@xysm.net
基金资助致谢
基金资助机构 授权号
National Natural Sciences Foundation of China
30700469
30871282
30871365
81172189
111 Project
111-2-12
Hunan Province Natural Sciences Foundation of China
10JJ7003
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出版商
HUMANA PRESS INC, 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
类别 / 分类
研究方向:Oncology
Web of Science 类别:Oncology
文献信息
文献类型:Article
语种:English
入藏号: WOS:000307964100008
PubMed ID: 22011934
ISSN: 1357-0560
期刊信息
目录： Current Contents Connect®
Impact Factor (影响因子): Journal Citation Reports®
其他信息
IDS 号: 994WE
Web of Science 核心合集中的 "引用的参考文献": 41
Web of Science 核心合集中的 "被引频次": 3 |
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