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genhunter

至尊木虫 (著名写手)

翻译EPI: 387
应助: 259 (大学生)
金币: 9757.4
散金: 10
红花: 60
帖子: 2484
在线: 1793小时
虫号: 2558361
注册: 2013-07-22
专业: 肿瘤化学药物治疗

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暮云深: 金币+30, 翻译EPI+1, ★★★★★最佳答案 2015-05-21 12:59:29
暮云深(RXMCDM代发): 金币+10 2015-05-24 23:46:06

1.PGE2 is synthesized by cyclooxygenase from eicosatetraenoic acids and its level in the fluid of knee joints in OA is highly elevated. It is known that PGE2 activates its receptor, increases the concentration of intracellular cAMP and then activates protein kinase A, which leads to apoptosis of articular chondrocytes。
2. The in vivo experimental model of OA is characterized by the degradation of articular cartilage mimicking the circumstances of OA patients. Also known is the fact that the apoptosis of articular chondrocytes is responsible for the degradation of articular cartilage. A treatment that leads to articular chondrocytes apoptosis in vitro and a condition that prevent such events are valuable both for mechanism studies of pathogenesis and developing new therapeutic interventions of OA。

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