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[×ÊÔ´] Drug Discovery for Schizophrenia

ÊéÃûDrug Discovery for Schizophrenia
×÷ÕßTatiana V Lipina, Tatiana V Lipina, John C Roder, David Thurston, Ana Martinez, Albert Wong, Peter Gebicke-Haerter, Raul Gainetdinov, Amy Ramsey, Urs Meyer, John Waddington, Inna Gaisler-Salomon, Nick Brandon, Bernard LeFoll, Fang Liu, Dennis Kaetzel, Martin Beaulieu
Ò³Êý302
³ö°æÉçRoyal Society of Chemistry 44
Chapter 1 The Genetics of Schizophrenia 1
James N. Samson and Albert H. C. Wong
1.1 Introduction 1
1.2 What Genetics Can Tell Us about Schizophrenia 2
1.2.1 The Heritability of Schizophrenia 2
1.2.2 The Genetic Architecture of Schizophrenia 3
1.3 The Tools of Genomics 5
1.4 What Genetics Has Told Us about Schizophrenia 7
1.4.1 Common Variation 8
1.4.2 Rare Variation 12
1.4.3 The Future of GWASs 15
1.5 What Genetics is Telling Us about Schizophrenia 16
1.6 The Limitations of Genetic Studies of Schizophrenia 17
1.7 Conclusion 18
1.8 Definitions 19
References 19
Chapter 2 The Impact of Epigenetics in Schizophrenia Research 28
Peter J. Gebicke-Haerter
2.1 Introduction 28
2.2 Genetic Epidemiology: The Hunt for Genes
Associated with Mental Disorders 29
2.3 Where is the missing heritability? 31
2.4 Epigenetics: A New Memory System in Neurobiology 33
2.4.1 DNA Methylation 34
2.4.2 Histone Methylation 35
2.4.3 Histone Acetylation 37
RSC Drug Discovery Series No. 44
Drug Discovery for Schizophrenia
Edited by Tatiana V. Lipina and John C. Roder
© The Royal Society of Chemistry 2015
Published by the Royal Society of Chemistry, www.rsc.org
10:30:17.
Published onDrug Discovery for Schizophrenia
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