|
[×ÊÔ´]
¡¶Àë×ÓͨµÀÊֲᡷ2015º£Íâ×îÐÂÊé¼®
ÊéÃû HANDBOOK OF
ION CHANNELS
×÷ÕßJie Zheng
University of California at Davis, USA
Matthew C. Trudeau
University of Maryland, Baltimore, USA
Ò³Êý672
³ö°æÉç Taylor & Francis Group
International Standard Book Number-13: 978-1-4665-5142-8 (eBook - PDF)
Contents
Foreword: Early days of ion channels ix
Preface xiii
Editors xv
Contributors xvii
PART I BASIC CONCEPTS 1
1. Electricity, nerves, batteries: A short history 3
Clay M. Armstrong
2. Ion selectivity and conductance 13
Dorothy M. Kim, Jason G. McCoy, and Crina M. Nimigean
3. Basic mechanisms of voltage sensing 25
Sandipan Chowdhury and Baron Chanda
4. Ligand-dependent gating mechanism 41
William N. Zagotta
5. Mechanosensitive channels and their emerging gating mechanisms 53
Sergei Sukharev and Andriy Anishkin
PART II ION CHANNEL METHODS 69
6. Patch clamping and single-channel analysis 71
Le¨®n D. Islas
7. Models of ion channel gating 83
Frank T. Horrigan and Toshinori Hoshi
8. Utilizing Markov chains to model ion channel sequence variation and kinetics 103
Anthony Fodor
9. Investigation of ion channel structure using fluorescence spectroscopy 113
Rikard Blunck
10. A practical guide to solving the structure of an ion channel protein 135
Tahmina Rahman and Declan A. Doyle
11. Structural study of ion channels by cryo-electron microscopy 149
Qiu-Xing Jiang and Liang Shi
12. Rosetta structural modeling 161
Vladimir Yarov-Yarovoy
13. Genetic methods for studying ion channel function in physiology and disease 167
Andrea L. Meredith
14. Ion channel inhibitors 189
Jon Sack and Kenneth S. Eum
15. High-throughput methods for ion channels 199
Haibo Yu and Min Li
PART III ION CHANNEL FAMILIES 211
16. Voltage-gated sodium channels 213
William A. Catterall
17. BK channels 227
512KUPnJC8L.jpg |
» ±¾Ìû¸½¼þ×ÊÔ´Áбí
» ÊÕ¼±¾ÌûµÄÌÔÌùר¼ÍƼö
» ±¾ÌûÒÑ»ñµÃµÄºì»¨£¨×îÐÂ10¶ä£©
» ²ÂÄãϲ»¶
|